| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphoma, Primary Effusion | D054685 | 2 associated lipids |
| Cocaine-Related Disorders | D019970 | 3 associated lipids |
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Genomic Instability | D042822 | 7 associated lipids |
| Leiomyoma | D007889 | 8 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitchell KA et al. | Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. | 2001 | Phytochemistry | pmid:11261578 |
| Brauch D et al. | Changes in isovitexin-O-glycosylation during the development of young barley plants. | 2018 | Phytochemistry | pmid:29421507 |
| Li FX et al. | Overexpression of the Saussurea medusa chalcone isomerase gene in S. involucrata hairy root cultures enhances their biosynthesis of apigenin. | 2006 | Phytochemistry | pmid:16427667 |
| Li X et al. | Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys. | 2006 | Phytochemistry | pmid:16777159 |
| Gormann R et al. | Newbouldiosides A-C, phenylethanoid glycosides from the stem bark of Newbouldia laevis. | 2006 | Phytochemistry | pmid:16497346 |
| Eyong KO et al. | Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis. | 2006 | Phytochemistry | pmid:16442576 |
| Ponce MA et al. | Flavonoids from shoots, roots and roots exudates of Brassica alba. | 2004 | Phytochemistry | pmid:15541742 |
| Materska M et al. | Isolation and structure elucidation of flavonoid and phenolic acid glycosides from pericarp of hot pepper fruit Capsicum annuum L. | 2003 | Phytochemistry | pmid:12895536 |
| Basile A et al. | Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta). | 2003 | Phytochemistry | pmid:12591270 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Greenham J et al. | A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. | 2001 | Phytochemistry | pmid:11198823 |
| Wahyuni Y et al. | Metabolite biodiversity in pepper (Capsicum) fruits of thirty-two diverse accessions: variation in health-related compounds and implications for breeding. | 2011 | Phytochemistry | pmid:21514607 |
| Pedras MS et al. | Phytoalexins from Thlaspi arvense, a wild crucifer resistant to virulent Leptosphaeria maculans: structures, syntheses and antifungal activity. | 2003 | Phytochemistry | pmid:14561510 |
| Svehliková V et al. | Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). | 2004 | Phytochemistry | pmid:15381003 |
| Shen P et al. | Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. | 2007 | Phytochemistry | pmid:17434191 |
| Ono E et al. | Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. | 2010 | Phytochemistry | pmid:20223486 |
| Zou Z et al. | Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. | 2017 | Phytochemistry | pmid:27889245 |
| Venturella P et al. | Three acylated flavone glycosides from Sideritis syriaca. | 1995 | Phytochemistry | pmid:7772308 |
| Disadee W et al. | Unprecedented furan-2-carbonyl C-glycosides and phenolic diglycosides from Scleropyrum pentandrum. | 2012 | Phytochemistry | pmid:22152976 |
| Palomino OM et al. | Isoscutellarein 7-glucosyl(1-->2)xyloside from sixteen species of Sideritis. | 1996 | Phytochemistry | pmid:8728059 |
| Amakura Y et al. | Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay. | 2008 | Phytochemistry | pmid:17869316 |
| Liu M et al. | An acylated flavone C-glycoside from Glycyrrhiza eurycarpa. | 1994 | Phytochemistry | pmid:7765208 |
| Toki K et al. | (Delphinidin 3-gentiobiosyl) (apigenin 7-glucosyl) malonate from the flowers of Eichhornia crassipes. | 1994 | Phytochemistry | pmid:7765361 |
| Fliegmann J et al. | Flavone synthase II (CYP93B16) from soybean (Glycine max L.). | 2010 | Phytochemistry | pmid:20132953 |
| Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
| Choudhary MI et al. | Hemiterpene glucosides and other constituents from Spiraea canescens. | Phytochemistry | pmid:19747701 | |
| Boveris AD et al. | Antioxidant capacity of a 3-deoxyanthocyanidin from soybean. | 2001 | Phytochemistry | pmid:11730874 |
| Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
| Martens S et al. | Cloning of parsley flavone synthase I. | 2001 | Phytochemistry | pmid:11524111 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Xu YC et al. | Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. | 2007 | Phytochemistry | pmid:17395220 |
| Lin YP et al. | Neural cell protective compounds isolated from Phoenix hanceana var. formosana. | 2009 | Phytochemistry | pmid:19628235 |
| Tabopda TK et al. | Bioactive aristolactams from Piper umbellatum. | 2008 | Phytochemistry | pmid:18400239 |
| Oliveira RR et al. | High-speed countercurrent chromatography as a valuable tool to isolate C-glycosylflavones from Cecropia lyratiloba Miquel. | 2003 Mar-Apr | Phytochem Anal | pmid:12693634 |
| Deepak M et al. | Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. | Phytochem Anal | pmid:15688952 | |
| Greenham J et al. | Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | Phytochem Anal | pmid:12693635 | |
| Guan Z et al. | Identification and quantitation of phenolic compounds from the seed and pomace of Perilla frutescens using HPLC/PDA and HPLC-ESI/QTOF/MS/MS. | Phytochem Anal | pmid:24737524 | |
| Saleem A et al. | Characterisation of phenolics in Flor-Essence--a compound herbal product and its contributing herbs. | 2009 Sep-Oct | Phytochem Anal | pmid:19609882 |
| Bertelli D et al. | ¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts. | 2012 May-Jun | Phytochem Anal | pmid:21853496 |
| Michler H et al. | Development of an LC-MS method for simultaneous quantitation of amentoflavone and biapigenin, the minor and major biflavones from Hypericum perforatum L., in human plasma and its application to real blood. | 2011 Jan-Feb | Phytochem Anal | pmid:20821812 |
| Pereira CA et al. | A HPTLC densitometric determination of flavonoids from Passiflora alata, P. edulis, P. incarnata and P. caerulea and comparison with HPLC method. | 2004 Jul-Aug | Phytochem Anal | pmid:15311844 |
| Kaiser CS et al. | Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin. | 2004 Jul-Aug | Phytochem Anal | pmid:15311845 |
| Martino E et al. | Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2''-O-rhamnoside from Crataegus monogyna Jacq. (hawthorn). | 2008 Nov-Dec | Phytochem Anal | pmid:18618435 |
| Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
| Fonseca FN and Tavares MF | Validation of a capillary electrophoresis method for the quantitative determination of free and total apigenin in extracts of Chamomilla recutita. | 2004 Jan-Feb | Phytochem Anal | pmid:14979529 |
| Pereira CA et al. | Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID. | 2005 Sep-Oct | Phytochem Anal | pmid:16223084 |
| Qiao X et al. | Qualitative and quantitative analyses of flavonoids in Spirodela polyrrhiza by high-performance liquid chromatography coupled with mass spectrometry. | 2011 Nov-Dec | Phytochem Anal | pmid:21465598 |
| Amat A et al. | Complexation of apigenin and luteolin in weld lake: a DFT/TDDFT investigation. | 2010 | Phys Chem Chem Phys | pmid:20419179 |
| Höfener S et al. | Fluorescence behavior of (selected) flavonols: a combined experimental and computational study. | 2013 | Phys Chem Chem Phys | pmid:23770806 |
| Baliga MS and Katiyar SK | Chemoprevention of photocarcinogenesis by selected dietary botanicals. | 2006 | Photochem. Photobiol. Sci. | pmid:16465310 |
| Agati G et al. | Flavonoid distribution in tissues of Phillyrea latifolia L. leaves as estimated by microspectrofluorometry and multispectral fluorescence microimaging. | 2002 | Photochem. Photobiol. | pmid:12403458 |
| Lu X et al. | Evaluation of hepatic clearance and drug-drug interactions of luteolin and apigenin by using primary cultured rat hepatocytes. | 2011 | Pharmazie | pmid:21901983 |
| Choi EM | Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha-induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells. | 2007 | Pharmazie | pmid:17416199 |
| Li LP et al. | Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics. | 2013 | Pharmazie | pmid:23556338 |
| Pieroni A and Pachaly P | Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. | 2000 | Pharmazie | pmid:10683879 |
| Lin Z et al. | In vivo effects of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 by cocktail probe drugs in rats. | 2014 | Pharmazie | pmid:25073400 |
| Merfort I et al. | In vivo skin penetration studies of camomile flavones. | 1994 | Pharmazie | pmid:8073060 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Tschiersch K and Hölzl J | [Absorption and excretion of apigenin, apigenin-7-glycoside and herniarin after oral administration of extracts of Matricaria recutita (L.) (syn. Chamomilla recutita (L.) Rauschert)]. | 1993 | Pharmazie | pmid:8415854 |
| Delazar A et al. | Two acylated flavonoid glycosides from Stachys bombycina, and their free radical scavenging activity. | 2005 | Pharmazie | pmid:16320954 |
| Je HG et al. | The inhibitory effect of vitexin on the agonist-induced regulation of vascular contractility. | 2014 | Pharmazie | pmid:24716414 |
| Cao F et al. | Mrp2-related efflux of scutellarin in the intestinal absorption in rats. | 2008 | Pharmazie | pmid:18271309 |
| An F et al. | Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and apigenin. | 2015 | Pharmazie | pmid:26790189 |
| Alali FQ et al. | LC-MS and LC-PDA vs. phytochemical analysis of Colchicum brachyphyllum. | 2008 | Pharmazie | pmid:19177900 |
| Al Shaal L et al. | smartCrystal combination technology--scale up from lab to pilot scale and long term stability. | 2010 | Pharmazie | pmid:21284256 |
| Hao X et al. | Study on the role of hepatic first-pass elimination in the low oral bioavailability of scutellarin in rats. | 2005 | Pharmazie | pmid:15997843 |
| Zhou Q et al. | Synthesis, characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG conjugates. | 2006 | Pharmazie | pmid:16964704 |
| Gobbi M et al. | In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. | 2001 | Pharmacopsychiatry | pmid:11518075 |
| Gharzouli K and Holzer P | Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein. | 2004 | Pharmacology | pmid:14646351 |
| Patil CS et al. | Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. | 2003 | Pharmacology | pmid:12928578 |
| Wang Z et al. | Inhibitory Effect of Apigenin on Losartan Metabolism and CYP2C9 Activity in vitro. | 2016 | Pharmacology | pmid:27287328 |
| Zhan YY et al. | Inhibitory Effect of Apigenin on Pharmacokinetics of Venlafaxine in vivo and in vitro. | 2015 | Pharmacology | pmid:26202346 |
| Nabavi SF et al. | Apigenin as neuroprotective agent: Of mice and men. | 2018 | Pharmacol. Res. | pmid:29055745 |
| Liu H et al. | Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. | 2005 | Pharmacol. Res. | pmid:15661569 |
| Demir Özkay U and Can OD | Anti-nociceptive effect of vitexin mediated by the opioid system in mice. | 2013 | Pharmacol. Biochem. Behav. | pmid:23639588 |
| Tang H et al. | Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. | 2014 | Pharmacol. Biochem. Behav. | pmid:24423938 |
| Occhiuto F et al. | Study on the action mechanism of some flavones through registration of intracardiac potentials in anesthetized dogs. | 1988 | Pharmacol Res Commun | pmid:3211997 |
| Kowalski J et al. | Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. | 2005 May-Jun | Pharmacol Rep | pmid:15985724 |
| Wójcik KA et al. | Apigenin inhibits TGF-β1 induced fibroblast-to-myofibroblast transition in human lung fibroblast populations. | 2013 | Pharmacol Rep | pmid:23563034 |
| Wu T et al. | Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). | 2017 | Pharmacol Rep | pmid:29128807 |
| Lee JA et al. | Effects of friedelin on the intestinal permeability and bioavailability of apigenin. | 2017 | Pharmacol Rep | pmid:28939344 |
| Fayek NM et al. | Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt. | 2012 | Pharmacognosy Res | pmid:22518080 |
| Shukla SH et al. | Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats. | 2010 | Pharmacognosy Res | pmid:21713139 |
| Venkateswara Rao G et al. | Chemical constituents and biological studies of Origanum vulgare Linn. | 2011 | Pharmacognosy Res | pmid:21772760 |
| Pareek A et al. | Feverfew (Tanacetum parthenium L.): A systematic review. | 2011 | Pharmacogn Rev | pmid:22096324 |
| Kumar A et al. | Erythrina variegata Linn: A review on morphology, phytochemistry, and pharmacological aspects. | 2010 | Pharmacogn Rev | pmid:22228954 |
| Saraf S and Kaur CD | Phytoconstituents as photoprotective novel cosmetic formulations. | 2010 | Pharmacogn Rev | pmid:22228936 |
| Prajapati MS et al. | Leucas aspera: A review. | 2010 | Pharmacogn Rev | pmid:22228946 |
| Sati SC et al. | Bioactive constituents and medicinal importance of genus Alnus. | 2011 | Pharmacogn Rev | pmid:22279375 |
| Johri RK | Cuminum cyminum and Carum carvi: An update. | 2011 | Pharmacogn Rev | pmid:22096320 |
| Gadekar R et al. | A potential of some medicinal plants as an antiulcer agents. | 2010 | Pharmacogn Rev | pmid:22228953 |
| Pattanayak P et al. | Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. | 2010 | Pharmacogn Rev | pmid:22228948 |
| Baikar S and Malpathak N | Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | 2010 | Pharmacogn Rev | pmid:22228937 |
| Bhadoriya SS et al. | Tamarindus indica: Extent of explored potential. | 2011 | Pharmacogn Rev | pmid:22096321 |
| Goyal M et al. | Aerva lanata: A review on phytochemistry and pharmacological aspects. | 2011 | Pharmacogn Rev | pmid:22279378 |
| Korać RR and Khambholja KM | Potential of herbs in skin protection from ultraviolet radiation. | 2011 | Pharmacogn Rev | pmid:22279374 |
| Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
| Singh O et al. | Chamomile (Matricaria chamomilla L.): An overview. | 2011 | Pharmacogn Rev | pmid:22096322 |
| Brito SA et al. | Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp. leaves and roots ethanolic extracts and conventional antifungals. | 2012 | Pharmacogn Mag | pmid:22701281 |
| Samarghandian S et al. | Honey induces apoptosis in renal cell carcinoma. | 2011 | Pharmacogn Mag | pmid:21472079 |