apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

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What genes are associated with apigenin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Authors Title Published Journal PubMed Link
Zheng YZ et al. The Substituent Effect on the Radical Scavenging Activity of Apigenin. 2018 Molecules pmid:30103379
Baruah TJ et al. Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. 2018 Mol. Biol. Rep. pmid:30099686
Chen S et al. A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. 2018 Molecules pmid:30037063
Vollmer M et al. Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples. 2018 J. Agric. Food Chem. pmid:29236499
Gao AM et al. Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. 2018 Chem. Biol. Interact. pmid:29191453
Park S et al. Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. 2018 J. Cell. Physiol. pmid:28617956
Pei Y et al. Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. 2018 Anim. Sci. J. pmid:29708294
Feng Y et al. Apigenin-7-O-β-d-(-6″-p-coumaroyl)-glucopyranoside pretreatment attenuates myocardial ischemia/reperfusion injury via activating AMPK signaling. 2018 Life Sci. pmid:29705352
Malar DS et al. Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. 2018 Life Sci. pmid:29704481
Hadrich F and Sayadi S Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. 2018 Lipids Health Dis pmid:29695233
Baluchnejadmojarad T et al. Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. 2018 Int. Immunopharmacol. pmid:29190543
Abdel-Salam NA et al. Flavonoids of Alcea rosea L. and their immune stimulant, antioxidant and cytotoxic activities on hepatocellular carcinoma HepG-2 cell line. 2018 Nat. Prod. Res. pmid:28580799
Kiyekbayeva L et al. Phytochemical constituents and antioxidant activity of Echinops albicaulis. 2018 Nat. Prod. Res. pmid:28475371
Mirzoeva S et al. Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor. 2018 Neoplasia pmid:30118999
You L et al. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. 2017 Bioorg. Med. Chem. Lett. pmid:29157862
Palacz-Wrobel M et al. Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. 2017 Biomed. Pharmacother. pmid:28738536
He X et al. Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. 2017 Am. J. Chin. Med. pmid:29121796
Wu W et al. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. 2017 Drug Deliv pmid:29115900
Tu F et al. Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. 2017 Int. J. Mol. Med. pmid:29039442
Dang Y et al. Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. 2017 Food Chem. Toxicol. pmid:28963002
Mehmood K et al. In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells. 2017 Avian Dis. pmid:28957003
Agah S et al. Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. 2017 Mol Nutr Food Res pmid:28155259
Viacava GE et al. Characterization of phenolic compounds in green and red oak-leaf lettuce cultivars by UHPLC-DAD-ESI-QToF/MS using MS scan mode. 2017 J Mass Spectrom pmid:28833875
Li F et al. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. 2017 Oxid Med Cell Longev pmid:28828145
Tan GF et al. AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. 2017 Plant Sci. pmid:28818381
Wang M et al. Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. 2017 Molecules pmid:28771188
Chen L et al. Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. 2017 Arch Gerontol Geriatr pmid:28743056
Gao C et al. Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. 2017 Oncol. Rep. pmid:28737827
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Jin X et al. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. 2017 Int J Nanomedicine pmid:28761344
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Seo HS et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. 2017 Oncol. Rep. pmid:28656316
Spilovska K et al. Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. 2017 Molecules pmid:28621747
Yang LL et al. Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal. 2017 Biochim Biophys Acta Mol Basis Dis pmid:27903431
Anusha C et al. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. 2017 Chem. Biol. Interact. pmid:28389404
Verma S et al. Natural polyphenolic inhibitors against the antiapoptotic BCL-2. 2017 J. Recept. Signal Transduct. Res. pmid:28264627
Kalivarathan J et al. Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet. 2017 Biomed. Pharmacother. pmid:28237914
Wang N et al. Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. 2017 In Vitro Cell. Dev. Biol. Anim. pmid:28181104
Telange DR et al. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. 2017 Eur J Pharm Sci pmid:27939619
Yao H et al. DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. 2017 Luminescence pmid:27860193
Molina Prats P et al. The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. 2017 J. Oral Pathol. Med. pmid:27378179
Zhang L et al. Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling. 2017 J. Mol. Recognit. pmid:28058739
Bhatt V et al. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF-MS/MS. 2017 J Pharm Biomed Anal pmid:27693952
Jeong KM et al. Identification of Major Flavone C-Glycosides and Their Optimized Extraction from Cymbidium kanran Using Deep Eutectic Solvents. 2017 Molecules pmid:29156555
Wu T et al. Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). 2017 Pharmacol Rep pmid:29128807
Hou L et al. Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. 2017 Med. Sci. Monit. pmid:29079722
Kulikovskii VF et al. Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. 2017 Bull. Exp. Biol. Med. pmid:29063320
Mokashi P et al. Swertisin rich fraction from Enicostema littorale ameliorates hyperglycemia and hyperlipidemia in high-fat fed diet and low dose streptozotacin induced type 2 diabetes mellitus in rats. 2017 Biomed. Pharmacother. pmid:29031588
Choi WH et al. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. 2017 Mol Nutr Food Res pmid:28971573
Zhao T et al. Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. 2017 Carbohydr Polym pmid:28962787
Liu Y et al. Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. 2017 Biomed. Pharmacother. pmid:28962085
Hassoun SM et al. Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. 2017 Tumour Biol. pmid:28651490
Wu Y et al. Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. 2017 Neurochem. Int. pmid:28947342
Lee JA et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin. 2017 Pharmacol Rep pmid:28939344
Sang Y et al. Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway. 2017 Food Funct pmid:28598487
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Malik S et al. Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. 2017 Am. J. Physiol. Renal Physiol. pmid:28566504
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Fernandes LM et al. Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. 2017 J Med Food pmid:28541831
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Ninfali P et al. C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. 2017 Phytother Res pmid:28464411
Han T et al. Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. 2017 Eur J Med Chem pmid:28458133
Adaszyńska-Skwirzyńska M and Dzięcioł M Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. 2017 Nat. Prod. Res. pmid:28449600
Mohammad F E et al. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. 2017 J. Biochem. Mol. Toxicol. pmid:28422384
Feng X et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. 2017 Biochem. Pharmacol. pmid:28414138
Li G et al. Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. 2017 Biochem. Biophys. Res. Commun. pmid:28408212
Wu W et al. Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. 2017 Drug Dev Ind Pharm pmid:28402147
Wan Y et al. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. 2017 Tumour Biol. pmid:28381178
Singhal SS et al. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. 2017 Biochim Biophys Acta Rev Cancer pmid:28359741
Zhang Z et al. Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. 2017 Drug Dev Ind Pharm pmid:28358225
Han Y et al. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. 2017 J Clin Neurosci pmid:28342702
Bian M et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. 2017 Brain Res. pmid:28336272
Chen F et al. An efficient approach for the extraction of orientin and vitexin from Trollius chinensis flowers using ultrasonic circulating technique. 2017 Ultrason Sonochem pmid:28427633
Lin CM et al. Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Sci Rep pmid:28337019
Pápay ZE et al. Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. 2017 J Aerosol Med Pulm Drug Deliv pmid:28282259
Rašković A et al. Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. 2017 Eur J Drug Metab Pharmacokinet pmid:28255865
Jangdey MS et al. Development and optimization of apigenin-loaded transfersomal system for skin cancer delivery: in vitro evaluation. 2017 Artif Cells Nanomed Biotechnol pmid:28050929
Yang N et al. Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. 2017 Mol Med Rep pmid:28035355
Banerjee K et al. Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. 2017 J Colloid Interface Sci pmid:28012918
Ke Y et al. Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. 2017 Biochem. Biophys. Res. Commun. pmid:27998773
Li Y et al. Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. 2017 J Chromatogr Sci pmid:27993862
Wang B and Zhao XH Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. 2017 Oncol. Rep. pmid:27959417
Bai Y et al. Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. 2017 Appl. Biochem. Biotechnol. pmid:27933483
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Gaballah HH et al. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. 2017 Toxicol. Appl. Pharmacol. pmid:28025107
Sheeja Malar D et al. Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. 2017 Pharm Biol pmid:27931177
Ganai SA Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. 2017 Biomed. Pharmacother. pmid:27930986
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Zou Z et al. Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. 2017 Fitoterapia pmid:27889540
Zou Z et al. Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. 2017 Phytochemistry pmid:27889245
Ketkaew Y et al. Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. 2017 Arch. Oral Biol. pmid:27886571
Liu H et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. 2017 J Chromatogr Sci pmid:27884870
Oh HK et al. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. 2017 J. Psychopharmacol. (Oxford) pmid:27729563
Guzelmeric E et al. Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. 2017 J Pharm Biomed Anal pmid:27693951
Wen L et al. Identification of a flavonoid C-glycoside as potent antioxidant. 2017 Free Radic. Biol. Med. pmid:28587909
Oliveira KG et al. Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. 2017 Food Chem pmid:27596435
Gutiérrez-Venegas G and González-Rosas Z Apigenin reduce lipoteichoic acid-induced inflammatory response in rat cardiomyoblast cells. 2017 Arch. Pharm. Res. pmid:27193174
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117
Gómez-Zorita S et al. Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes. 2017 J Transl Med pmid:29162103