apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Tian Y et al. [The effect of apigenin on reproductive axis in female rats]. 2011 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21845881
Pang LL et al. [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. 2010 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20669675
Guo LL et al. [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21823425
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Zhang J et al. [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12516463
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Shi S et al. [Evaluation of brain-targeted trendence of scutellarin nasal administration]. 2010 Zhongguo Zhong Yao Za Zhi pmid:21141499
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Cheng YB et al. [Study on chemical constituents in rhizome of Smilax perfoliate]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015307
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Huo CH et al. [Studies on chemical constituents in herbs of Acanthus ilicifolius]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16075716
Liu Z et al. [Determination of orientin and vitexin in Trollius chinesis preparation by HPLC]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15656135
Ding L et al. [Studies on the flavonoid constituents in herb of Eremosparton songoricum]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15714817
Wang LS et al. [Study on the chemical constituents from Picria fel-tarrae]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15719682
Tian J et al. [Studies on the chemical constitutents in herb of Verbena officinalis]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15724402
Gu HF et al. [Studies on chemical constituents from herb of Dracocephalum moldavica]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706847
Su J et al. [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706914
Zhao DB et al. [Studies on chemical constituents in herb of Chondrilla piptocoma]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011281
Dai C et al. [Studies on chemical constituents from moss Rhodobryum roseum II]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048608
Hua Y and Wang HQ [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048665
Zhu XX et al. [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16780160
Zhang Y et al. [Effect of caffeic acid, seopoletin and scutellarin on rat retinal neurons in vitro]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16124607
Che QM et al. [Study on bile excretion of scutellarein]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17225543
Liu JY et al. [Optimizing extraction process of Scutellaria barbata by golden section method]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18619346
Dawa ZM et al. [Studies on chemical constituents of Saussurea laniceps]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18652351
Qu L et al. [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18720869
He Y et al. [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22715732
Qin S and Wen X [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22779181
Ye S et al. [Scutellarin starch microspheres' permeability through nasal mucosa of different animals in vitro]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22693914
Huang Y et al. [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22667158
Huang Y et al. [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22375405
Han SL et al. [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23672040
Zhu R et al. [Study on estrogenic effect of genistein and apigenin in vitro]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23189742
Tong C and Wu X [Determination of plasma protein binding rate of vitexin]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23126208
Li YL et al. [Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23717958
He CH et al. [Study on intestinal absorption kinetics of apigenin in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23944080
Li XB et al. [Simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigeron breviscapus by high-performance liquid chromatography]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24199546
Liu T et al. [Relationship between expression of chalcone synthase gene (CHS) and scutellarin content in Erigeron breviscapus]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24199547
Zheng XX et al. [Role of ERK/FoxO3a signal axis in inhibitory effect of vitexin 1 (VB-1) in HepG2 cell proliferation]. 2014 Zhongguo Zhong Yao Za Zhi pmid:25011268
Zhu LW et al. [Pharmacokinetics of scutellarin and its derivant scutellarin ethyl ester in rats]. 2013 Zhongguo Zhong Yao Za Zhi pmid:24422411
Li YR et al. [Quality standard study on Vigna radiata]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24754176
Wu QP et al. [Determination of five primary chemical constituents in Cassia angustifolia by HPLC]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18533485
Shi T et al. [Effect of apigenin on protein expressions of PPARs in liver tissues of rats with nonalcoholic steatohepatitis]. 2015 Zhonghua Gan Zang Bing Za Zhi pmid:25880979
Shi XR et al. [Apigenin affects semen parameters in male mice]. 2010 Zhonghua Nan Ke Xue pmid:21171258
Yao HM et al. [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. 2017 Zhonghua Xin Xue Guan Bing Za Zhi pmid:28545285
Xing Y et al. [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. 2002 Zhonghua Yi Xue Za Zhi pmid:12509912
Wang LY et al. [Apigenin regulates lipopolysaccharides-induced activation of inflammasome]. 2011 Zhonghua Yi Xue Za Zhi pmid:22321793
Jin XY and Ren CS [Effect and mechanism of apigenin on VEGF expression in human breast cancer cells]. 2007 Zhonghua Zhong Liu Za Zhi pmid:18069627
Tatemoto H et al. Inhibition of boar sperm hyaluronidase activity by tannic acid reduces polyspermy during in vitro fertilization of porcine oocytes. 2006 Zygote pmid:17266786