apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Oberdörster E et al. Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. 2001 J. Steroid Biochem. Mol. Biol. pmid:11457661
Begum AA et al. Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments. 2001 J. Exp. Bot. pmid:11457914
Matławska I Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). 2001 Mar-Apr Acta Pol Pharm pmid:11501790
Gobbi M et al. In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. 2001 Pharmacopsychiatry pmid:11518075
Aquino R et al. Phenolic constituents and antioxidant activity of an extract of Anthuriumversicolor leaves. 2001 J. Nat. Prod. pmid:11520218
Kyriakopoulou I et al. Samioside, a new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. 2001 J. Nat. Prod. pmid:11520237
Haribal M and Renwick JA Seasonal and population variation in flavonoid and alliarinoside content of Alliaria petiolata. 2001 J. Chem. Ecol. pmid:11521398
Martens S et al. Cloning of parsley flavone synthase I. 2001 Phytochemistry pmid:11524111
Abou-Zaid MM et al. Acylated flavone C-glycosides from Cucumis sativus. 2001 Phytochemistry pmid:11524127
Stull ND et al. Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins. 2001 Brain Res. Dev. Brain Res. pmid:11557097
Gupta S et al. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. 2001 Biochem. Biophys. Res. Commun. pmid:11573952
Witte MC et al. Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry. 2001 Eur. J. Neurosci. pmid:11576187
Kong LD et al. Glycosides and xanthine oxidase inhibitors from Conyza bonariensis. 2001 Phytochemistry pmid:11576616
Neff L et al. NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci. 2001 Cell. Microbiol. pmid:11580755
Qu J et al. Identification and determination of glucuronides and their aglycones in Erigeron breviscapus by liquid chromatography-tandem mass spectrometry. 2001 J Chromatogr A pmid:11587333
Lindenmeyer F et al. Apigenin acts on the tumor cell invasion process and regulates protease production. 2001 Nutr Cancer pmid:11588896
Ricupero DA et al. Apigenin decreases expression of the myofibroblast phenotype. 2001 FEBS Lett. pmid:11591363
Saarinen N et al. No evidence for the in vivo activity of aromatase-inhibiting flavonoids. 2001 J. Steroid Biochem. Mol. Biol. pmid:11595503
Shen YX et al. [Studies on the flavonoids from Dendranthema lavandulifolium]. 1997 Yao Xue Xue Bao pmid:11596327
Galietta LV et al. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. 2001 Am. J. Physiol., Cell Physiol. pmid:11600438