| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Astrocytoma | D001254 | 15 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitchell KA et al. | Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. | 2001 | Phytochemistry | pmid:11261578 |
| Liu JQ et al. | [Studies on the chemical constituents from Chrysanthemum morifolium Ramat]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776368 |
| Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
| Stull ND et al. | Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins. | 2001 | Brain Res. Dev. Brain Res. | pmid:11557097 |
| Abou-Zaid MM et al. | Acylated flavone C-glycosides from Cucumis sativus. | 2001 | Phytochemistry | pmid:11524127 |
| Haribal M and Renwick JA | Seasonal and population variation in flavonoid and alliarinoside content of Alliaria petiolata. | 2001 | J. Chem. Ecol. | pmid:11521398 |
| Makino T et al. | Inhibitory effect of decoction of Perilla frutescens on cultured murine mesangial cell proliferation and quantitative analysis of its active constituents. | 2001 | Planta Med. | pmid:11270716 |
| Oberdörster E et al. | Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11457661 |
| Miean KH and Mohamed S | Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. | 2001 | J. Agric. Food Chem. | pmid:11410016 |
| Sun J et al. | [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. | 2001 | Zhong Yao Cai | pmid:11917841 |
| Kitada C et al. | Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11773526 |
| Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
| Begum AA et al. | Specific flavonoids induced nod gene expression and pre-activated nod genes of Rhizobium leguminosarum increased pea (Pisum sativum L.) and lentil (Lens culinaris L.) nodulation in controlled growth chamber environments. | 2001 | J. Exp. Bot. | pmid:11457914 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Kim HR et al. | Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2. | 2001 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11993721 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Takahama U et al. | Oxidation of quercetin by salivary components. Quercetin-dependent reduction of salivary nitrite under acidic conditions producing nitric oxide. | 2002 | J. Agric. Food Chem. | pmid:12105964 |
| Nagao T et al. | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. | 2002 | Biol. Pharm. Bull. | pmid:12132661 |
| Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
| Lorentz A et al. | Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins. | 2002 | Blood | pmid:11807000 |
| Li J and Chen YT | [Two flavonoids from Lagopsis supina]. | 2002 | Yao Xue Xue Bao | pmid:12579758 |
| Liu H et al. | [Study on effects of scutellarin on scavenging reactive oxygen]. | 2002 | Zhong Yao Cai | pmid:12599762 |
| Koo H et al. | Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. | 2002 | Oral Microbiol. Immunol. | pmid:12485324 |
| Wang H et al. | Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. | 2002 | Planta Med. | pmid:12494329 |
| Xing Y et al. | [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation]. | 2002 | Zhonghua Yi Xue Za Zhi | pmid:12509912 |
| Han DH et al. | Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224631 |
| Lee S et al. | Phytochemical constituents from the herba of Artemisia apiacea. | 2002 | Arch. Pharm. Res. | pmid:12135098 |
| Prescott AG et al. | In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:12126705 |
| Liu Y and Hu M | Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. | 2002 | Drug Metab. Dispos. | pmid:11901089 |
| Exarchou V et al. | Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory. | 2002 | J. Agric. Food Chem. | pmid:12207464 |
| Mastuda H et al. | Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells. | 2002 | Bioorg. Med. Chem. | pmid:12150856 |
| Walle UK and Walle T | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. | 2002 | Drug Metab. Dispos. | pmid:11950788 |
| Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
| Tsuchiya H et al. | Membrane-rigidifying effects of anti-cancer dietary factors. | 2002 | Biofactors | pmid:14530593 |
| Bito T et al. | Flavonoids differentially regulate IFN gamma-induced ICAM-1 expression in human keratinocytes: molecular mechanisms of action. | 2002 | FEBS Lett. | pmid:12044887 |
| Ma T et al. | High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. | 2002 | J. Biol. Chem. | pmid:12161441 |
| Lin CM et al. | Molecular modeling of flavonoids that inhibits xanthine oxidase. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054758 |
| Rawel HM et al. | Interactions of different phenolic acids and flavonoids with soy proteins. | 2002 | Int. J. Biol. Macromol. | pmid:12063116 |
| Marder M and Paladini AC | GABA(A)-receptor ligands of flavonoid structure. | 2002 | Curr Top Med Chem | pmid:12171576 |
| Grayer RJ et al. | Scutellarein 4'-methyl ether glycosides as taxonomic markers in Teucridium and Tripora (Lamiaceae, Ajugoideae). | 2002 | Phytochemistry | pmid:12127590 |
| Gil-Izquierdo A et al. | Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. | 2002 | J. Agric. Food Chem. | pmid:12188615 |
| Kim TJ et al. | Effects of apigenin on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. | 2002 | Planta Med. | pmid:12142993 |
| Channavajhala P and Seldin DC | Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. | 2002 | Oncogene | pmid:12149649 |
| Aboutabl EA et al. | Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. | 2002 | J Ethnopharmacol | pmid:12241993 |
| Rager I et al. | Rapid quantification of constituents in St. John's wort extracts by NIR spectroscopy. | 2002 | J Pharm Biomed Anal | pmid:12008122 |
| Kim MK et al. | Relationships of urinary phyto-oestrogen excretion to BMD in postmenopausal women. | 2002 | Clin. Endocrinol. (Oxf) | pmid:11940043 |
| Vanhoenacker G et al. | Chemotaxonomic features associated with flavonoids of cannabinoid-free cannabis (Cannabis sativa subsp. sativa L.) in relation to hops (Humulus lupulus L.). | 2002 | Nat Prod Lett | pmid:11942684 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |