apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

Cross Reference

Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Asthma D001249 52 associated lipids
Astrocytoma D001254 15 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Palmieri D et al. Estrogen receptor activation protects against TNF-α-induced endothelial dysfunction. 2014 Angiology pmid:23427281
Pei Y et al. Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. 2018 Anim. Sci. J. pmid:29708294
Mendel M et al. Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. 2016 Animal pmid:27534882
Li N et al. A possible quantitative method to improve the sensitivity of scutellarin in human plasma. 2005 Ann Chim pmid:16136842
Agati G et al. Mesophyll distribution of 'antioxidant' flavonoid glycosides in Ligustrum vulgare leaves under contrasting sunlight irradiance. 2009 Ann. Bot. pmid:19633310
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Huang ST et al. Inhibitory effects of a rice hull constituent on tumor necrosis factor alpha, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages. 2005 Ann. N. Y. Acad. Sci. pmid:15965085
Meyer H et al. Bioavailability of apigenin from apiin-rich parsley in humans. 2006 Ann. Nutr. Metab. pmid:16407641
Ross JA and Kasum CM Dietary flavonoids: bioavailability, metabolic effects, and safety. 2002 Annu. Rev. Nutr. pmid:12055336
Nabavi SM et al. Apigenin and Breast Cancers: From Chemistry to Medicine. 2015 Anticancer Agents Med Chem pmid:25738871
Tong X and Pelling JC Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. 2013 Anticancer Agents Med Chem pmid:23272913
Shen M et al. Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization. 2012 Anticancer Agents Med Chem pmid:22292765
Seydi E et al. Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria. 2016 Anticancer Agents Med Chem pmid:27109019
Zhou J et al. Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. 2013 Anticancer Drugs pmid:23965728
Zhou Z et al. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. 2017 Anticancer Drugs pmid:28125432
Coelho PL et al. The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. 2016 Anticancer Drugs pmid:27622606
Lünenbürger H et al. Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines. 2010 Anticancer Drugs pmid:20147838
Yin F et al. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). 1999 Sep-Oct Anticancer Res. pmid:10628390
Chan JY et al. Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. 2009 Anticancer Res. pmid:19661313
Kim SH et al. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. 2015 Anticancer Res. pmid:26637867