| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Paredes-Gonzalez X et al. | Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications. | 2014 | AAPS J | pmid:24830944 |
| Baiga TJ et al. | Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. | 2008 | ACS Chem. Biol. | pmid:18376812 |
| Vitalini S et al. | Phenolic compounds from Achillea millefolium L. and their bioactivity. | 2011 | Acta Biochim. Pol. | pmid:21503279 |
| Sahin M et al. | Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation. | 2012 | Acta Histochem. | pmid:21474164 |
| Hashemi M et al. | Anti-mutagenic and pro-apoptotic effects of apigenin on human chronic lymphocytic leukemia cells. | 2010 Sep-Oct | Acta Med Iran | pmid:21287458 |
| Ovodov YS | Bioglycans and natural glycosides as a promising research topic in bioorganic chemistriy. | 2010 | Acta Naturae | pmid:22649639 |
| Janeska B et al. | Assay of flavonoid aglycones from the species of genus Sideritis (Lamiaceae) from Macedonia with HPLC-UV DAD. | 2007 | Acta Pharm | pmid:17878116 |
| Kosalec I et al. | Analysis of propolis from the continental and Adriatic regions of Croatia. | 2003 | Acta Pharm | pmid:14769234 |
| Pápay ZE et al. | [Pharmaceutical and formulation aspects of Petroselinum crispum extract]. | 2012 | Acta Pharm Hung | pmid:22570982 |
| Xu W et al. | Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation. | 2007 | Acta Pharmacol. Sin. | pmid:17883942 |
| Gao R et al. | Scutellarein inhibits hypoxia- and moderately-high glucose-induced proliferation and VEGF expression in human retinal endothelial cells. | 2008 | Acta Pharmacol. Sin. | pmid:18501117 |
| Guo LL et al. | Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase. | 2011 | Acta Pharmacol. Sin. | pmid:21986571 |
| Liu H et al. | Protective effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. | 2003 | Acta Pharmacol. Sin. | pmid:14627495 |
| Hu XM et al. | Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. | 2005 | Acta Pharmacol. Sin. | pmid:16297343 |
| Xing JF et al. | Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces. | 2011 | Acta Pharmacol. Sin. | pmid:21516133 |
| Nazaruk J and Gudej J | Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. | 2003 Jan-Feb | Acta Pol Pharm | pmid:12848373 |
| Patora J and Klimek B | Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365606 |
| Matławska I and Sikorska M | Flavonoid compounds in the flowers of Abutilon indicum (L.) Sweet (Malvaceae). | 2002 May-Jun | Acta Pol Pharm | pmid:12230251 |
| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Bylka W | Isovitexin o-glucosides from Aquilegia vulgaris L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693732 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Bylka W and Matławska I | Flavonoids from Aquilegia vulgaris L. Part II. Derivatives of apigenin and luteolin. | 1997 Jul-Aug | Acta Pol Pharm | pmid:9511462 |
| Modnicki D et al. | Flavonoids and phenolic acids of Nepeta cataria L. var. citriodora (Becker) Balb. (Lamiaceae). | 2007 May-Jun | Acta Pol Pharm | pmid:17695148 |
| Nazaruk J | Flavonoid aglycones and phytosterols from the Erigeron acris L. herb. | 2006 Jul-Aug | Acta Pol Pharm | pmid:17203871 |
| Mazol I et al. | Polyphenolic compounds from Platycodon grandiflorum A. DC. | 2004 May-Jun | Acta Pol Pharm | pmid:15481246 |
| Krcatović E et al. | Inhibition of tobacco mosaic virus infection by quercetin and vitexin. | 2008 | Acta Virol. | pmid:18564899 |
| Horbowicz M et al. | Effects of methyl jasmonate on accumulation of flavonoids in seedlings of common buckwheat (Fagopyrum esculentum Moench). | 2011 | Acta. Biol. Hung. | pmid:21840829 |
| Dhawan K | Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. | 2003 | Addict Biol | pmid:14690874 |
| Kowalczyk A et al. | Insights into novel anticancer applications for apigenin. | 2017 | Adv Clin Exp Med | pmid:29211364 |
| Koo H and Jeon JG | Naturally occurring molecules as alternative therapeutic agents against cariogenic biofilms. | 2009 | Adv. Dent. Res. | pmid:19717411 |
| Koo H | Strategies to enhance the biological effects of fluoride on dental biofilms. | 2008 | Adv. Dent. Res. | pmid:18694872 |
| Shu-Yao Z et al. | In vitro evidence of possible influence of scutellarein towards bile acids' metabolism. | 2013 | Afr Health Sci | pmid:24250288 |
| Hashem FA et al. | Phenolic compounds and bioactivity of leaves of Mayodendron igneum Kurz. | 2007 | Afr J Tradit Complement Altern Med | pmid:20161894 |
| Ito M et al. | GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. | 2011 | Aging (Albany NY) | pmid:22207314 |
| Martins I et al. | Hormesis, cell death and aging. | 2011 | Aging (Albany NY) | pmid:21931183 |
| Zhu F et al. | [Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro]. | 2003 | Ai Zheng | pmid:12703988 |
| Chang H et al. | [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. | 2007 | Ai Zheng | pmid:18076792 |
| Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
| Kawai M et al. | Flavonoids and related compounds as anti-allergic substances. | 2007 | Allergol Int | pmid:17384531 |
| Amsterdam JD et al. | Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. | 2012 Sep-Oct | Altern Ther Health Med | pmid:22894890 |
| Brantner AH et al. | HET-CAM bioassay as in vitro alternative to the croton oil test for investigating steroidal and non-steroidal compounds. | 2002 | ALTEX | pmid:12098009 |
| He X et al. | Absorption Properties of Luteolin and Apigenin in Genkwa Flos Using In Situ Single-Pass Intestinal Perfusion System in the Rat. | 2017 | Am. J. Chin. Med. | pmid:29121796 |
| Chledzik S et al. | Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. | 2018 | Am. J. Chin. Med. | pmid:29433387 |
| Dong LY et al. | Mechanisms of vitexin preconditioning effects on cultured neonatal rat cardiomyocytes with anoxia and reoxygenation. | 2008 | Am. J. Chin. Med. | pmid:18457368 |
| Dong LY et al. | Cardioprotection of vitexin on myocardial ischemia/reperfusion injury in rat via regulating inflammatory cytokines and MAPK pathway. | 2013 | Am. J. Chin. Med. | pmid:24228599 |
| Tsai JC et al. | Hepatoprotective effect of Scoparia dulcis on carbon tetrachloride induced acute liver injury in mice. | 2010 | Am. J. Chin. Med. | pmid:20626061 |
| Jiang DP et al. | Scutellarin attenuates human-neutrophil-elastase-induced mucus production by inhibiting the PKC-ERK signaling pathway in vitro and in vivo. | 2011 | Am. J. Chin. Med. | pmid:22083990 |
| Shin JW et al. | Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. | 2018 | Am. J. Chin. Med. | pmid:30149759 |
| Kim HJ et al. | Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition. | 2018 | Am. J. Chin. Med. | pmid:30149756 |
| Cassidy A et al. | Habitual intake of flavonoid subclasses and incident hypertension in adults. | 2011 | Am. J. Clin. Nutr. | pmid:21106916 |
| Soares R and Azevedo I | Apigenin: is it a pro- or anti-inflammatory agent? | 2006 | Am. J. Pathol. | pmid:16651640 |
| Sawatzky DA et al. | The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo. | 2006 | Am. J. Pathol. | pmid:16400007 |
| Farah M et al. | 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12842827 |
| Caci E et al. | CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12651632 |
| Fischer H et al. | Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11404245 |
| Niisato N et al. | Involvement of cytosolic Cl- in osmoregulation of alpha-ENaC gene expression. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15292045 |
| Malik S et al. | Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566504 |
| Illek B et al. | Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11078699 |
| Galietta LV et al. | Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11600438 |
| Lim M et al. | Modulation of deltaF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:15191910 |
| Scippo ML et al. | Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. | 2004 | Anal Bioanal Chem | pmid:14579009 |
| Diniz A et al. | Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis. | 2008 | Anal Bioanal Chem | pmid:18418586 |
| Mantzouris D et al. | HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. | 2011 | Anal Bioanal Chem | pmid:21271239 |
| Tang D et al. | Simultaneous chemical fingerprint and quantitative analysis of Ginkgo biloba extract by HPLC-DAD. | 2010 | Anal Bioanal Chem | pmid:20191266 |
| Cao Y et al. | Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. | 2002 | Anal Bioanal Chem | pmid:12324852 |
| Lech K and Jarosz M | Novel methodology for the extraction and identification of natural dyestuffs in historical textiles by HPLC-UV-Vis-ESI MS. Case study: chasubles from the Wawel Cathedral collection. | 2011 | Anal Bioanal Chem | pmid:21188578 |
| Mylonaki S et al. | Optimisation of the extraction of olive (Olea europaea) leaf phenolics using water/ethanol-based solvent systems and response surface methodology. | 2008 | Anal Bioanal Chem | pmid:18762919 |
| Valianou L et al. | Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography. | 2009 | Anal Bioanal Chem | pmid:19798487 |
| Singh N et al. | Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography. | 2013 | Anal. Biochem. | pmid:23376017 |
| Exarchou V et al. | LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano. | 2003 | Anal. Chem. | pmid:14616013 |
| Gao M et al. | Microwave-assisted extraction of scutellarin from Erigeron breviscapus Hand-Mazz and its determination by high-performance liquid chromatography. | 2007 | Anal. Chim. Acta | pmid:17481403 |
| Gouvea DR et al. | A new HPLC-DAD-MS/MS method for the simultaneous determination of major compounds in the crude extract of Lychnophora salicifolia Mart. (Brazilian arnicão) leaves: application to chemical variability evaluation. | 2012 | Anal. Chim. Acta | pmid:23021804 |
| Jones MD et al. | Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts. | 2014 | Anal. Chim. Acta | pmid:25261902 |
| Ozyürek M et al. | Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method. | 2009 | Anal. Chim. Acta | pmid:19231354 |
| Christophoridou S and Dais P | Detection and quantification of phenolic compounds in olive oil by high resolution 1H nuclear magnetic resonance spectroscopy. | 2009 | Anal. Chim. Acta | pmid:19166735 |
| Palmieri D et al. | Estrogen receptor activation protects against TNF-α-induced endothelial dysfunction. | 2014 | Angiology | pmid:23427281 |
| Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
| Mendel M et al. | Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. | 2016 | Animal | pmid:27534882 |
| Li N et al. | A possible quantitative method to improve the sensitivity of scutellarin in human plasma. | 2005 | Ann Chim | pmid:16136842 |
| Agati G et al. | Mesophyll distribution of 'antioxidant' flavonoid glycosides in Ligustrum vulgare leaves under contrasting sunlight irradiance. | 2009 | Ann. Bot. | pmid:19633310 |
| Ganesan K and Xu B | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. | 2017 | Ann. N. Y. Acad. Sci. | pmid:28891090 |
| Huang ST et al. | Inhibitory effects of a rice hull constituent on tumor necrosis factor alpha, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15965085 |
| Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Nabavi SM et al. | Apigenin and Breast Cancers: From Chemistry to Medicine. | 2015 | Anticancer Agents Med Chem | pmid:25738871 |
| Tong X and Pelling JC | Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention. | 2013 | Anticancer Agents Med Chem | pmid:23272913 |
| Shen M et al. | Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization. | 2012 | Anticancer Agents Med Chem | pmid:22292765 |
| Seydi E et al. | Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria. | 2016 | Anticancer Agents Med Chem | pmid:27109019 |
| Zhou J et al. | Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway. | 2013 | Anticancer Drugs | pmid:23965728 |
| Zhou Z et al. | Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. | 2017 | Anticancer Drugs | pmid:28125432 |
| Coelho PL et al. | The flavonoid apigenin from Croton betulaster Mull inhibits proliferation, induces differentiation and regulates the inflammatory profile of glioma cells. | 2016 | Anticancer Drugs | pmid:27622606 |
| Lünenbürger H et al. | Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines. | 2010 | Anticancer Drugs | pmid:20147838 |
| Chan JY et al. | Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation. | 2009 | Anticancer Res. | pmid:19661313 |
| Cheong JW et al. | Inhibition of CK2{alpha} and PI3K/Akt synergistically induces apoptosis of CD34+CD38- leukaemia cells while sparing haematopoietic stem cells. | 2010 | Anticancer Res. | pmid:21115916 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |