apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Okitsu N et al. Identification and Characterization of Novel Nemophila menziesii Flavone Glucosyltransferases that Catalyze Biosynthesis of Flavone 7,4'-O-Diglucoside, a Key Component of Blue Metalloanthocyanins. 2018 Plant Cell Physiol. pmid:29986079
Mekawy AMM et al. Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings. 2018 Plant Physiol. Biochem. pmid:29980098
Lorizola IM et al. Beet Stalks and Leaves ( L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. 2018 Nutrients pmid:29976910
Zhang Y et al. Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. 2018 Biomed. Pharmacother. pmid:29966983
Wong TY et al. Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. 2018 J. Pharm. Pharmacol. pmid:29943490
Jiang PY et al. Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. 2018 Microb. Pathog. pmid:29928944
Mo J et al. Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. 2018 Phytomedicine pmid:29655699
Kumar KS et al. Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity. 2018 Int. Immunopharmacol. pmid:29655057
Paredes MD et al. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. 2018 Nutrients pmid:29652818
Zeng YQ et al. Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. 2018 Molecules pmid:29642616
Gentile D et al. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. 2018 PLoS ONE pmid:29641549
Venturini CL et al. Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma. 2018 Biomed. Pharmacother. pmid:29091859
Gadioli IL et al. A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. 2018 Crit Rev Food Sci Nutr pmid:27645583
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Palacz-Wrobel M et al. Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages. 2017 Biomed. Pharmacother. pmid:28738536
Li F et al. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy. 2017 Oxid Med Cell Longev pmid:28828145
Tan GF et al. AgFNS overexpression increase apigenin and decrease anthocyanins in petioles of transgenic celery. 2017 Plant Sci. pmid:28818381
Pate KM et al. Anthoxanthin Polyphenols Attenuate Aβ Oligomer-induced Neuronal Responses Associated with Alzheimer's Disease. 2017 CNS Neurosci Ther pmid:27864869
Wang M et al. Apigenin Impacts the Growth of the Gut Microbiota and Alters the Gene Expression of Enterococcus. 2017 Molecules pmid:28771188
Chen L et al. Apigenin attenuates isoflurane-induced cognitive dysfunction via epigenetic regulation and neuroinflammation in aged rats. 2017 Arch Gerontol Geriatr pmid:28743056
Gao C et al. Cytotoxic and chemosensitization effects of Scutellarin from traditional Chinese herb Scutellaria altissima L. in human prostate cancer cells. 2017 Oncol. Rep. pmid:28737827
Ghazanfar K et al. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles. 2017 J Complement Integr Med pmid:28731312
Sun Y et al. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. 2017 Molecules pmid:28696360
Seo HS et al. Apigenin overcomes drug resistance by blocking the signal transducer and activator of transcription 3 signaling in breast cancer cells. 2017 Oncol. Rep. pmid:28656316
Spilovska K et al. Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation. 2017 Molecules pmid:28621747
Salmani JMM et al. Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives. 2017 Chin J Nat Med pmid:28558867
Elmasri WA et al. Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization. 2017 J. Proteome Res. pmid:28541047
Yang PM et al. Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. 2017 Oncotarget pmid:28526810
Elhennawy MG and Lin HS Quantification of apigenin trimethyl ether in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study. 2017 J Pharm Biomed Anal pmid:28494337
Souza RP et al. Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines. 2017 Oxid Med Cell Longev pmid:28191273
Alvin JW and Lacy DB Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. 2017 J. Struct. Biol. pmid:28433497
Nelson N et al. Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer. 2017 PLoS ONE pmid:28152014
Min JW et al. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. 2017 Oncotarget pmid:28424420
Wang F et al. Vitexin alleviates lipopolysaccharide‑induced islet cell injury by inhibiting HMGB1 release. 2017 Mol Med Rep pmid:28098903
Wu CC et al. Inhibition of Epstein-Barr virus reactivation by the flavonoid apigenin. 2017 J. Biomed. Sci. pmid:28056971
Perrott KM et al. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. 2017 Geroscience pmid:28378188
Anusha C et al. Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis. 2017 Chem. Biol. Interact. pmid:28389404
Yao H et al. DPPH·-luminol chemiluminescence system and its application in the determination of scutellarin in pharmaceutical injections and rat plasma with flow injection analysis. 2017 Luminescence pmid:27860193
Molina Prats P et al. The therapeutic effects of apigenin and dexamethasone on 5-fluorouracil-induced oral mucositis - a pilot study using a Syrian hamster model. 2017 J. Oral Pathol. Med. pmid:27378179
Naik PM and Al-Khayri JM Extraction and Estimation of Secondary Metabolites from Date Palm Cell Suspension Cultures. 2017 Methods Mol. Biol. pmid:28755356
Grigalius I and Petrikaite V Relationship between Antioxidant and Anticancer Activity of Trihydroxyflavones. 2017 Molecules pmid:29215574
Liao M et al. Metabolites identificaion of two bioactive constituents in Trollius ledebourii in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29127056
Medhat AM et al. Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice. 2017 Tumour Biol. pmid:29022496
Ganesan K and Xu B Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. 2017 Ann. N. Y. Acad. Sci. pmid:28891090
Zhou RJ et al. Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28867192
Shan S et al. Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. 2017 J. Agric. Food Chem. pmid:28829588
Britto SM et al. Apigenin prevents ultraviolet-B radiation induced cyclobutane pyrimidine dimers formation in human dermal fibroblasts. 2017 Mutat. Res. pmid:28735741
Wen L et al. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. 2017 Molecules pmid:28486427
Choi WH et al. Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice. 2017 Mol Nutr Food Res pmid:28971573
Zhao T et al. Novel apigenin-loaded sodium hyaluronate nano-assemblies for targeting tumor cells. 2017 Carbohydr Polym pmid:28962787
Liu Y et al. Effects of apigenin pretreatment against renal ischemia/reperfusion injury via activation of the JAK2/STAT3 pathway. 2017 Biomed. Pharmacother. pmid:28962085
Wu Y et al. Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase. 2017 Neurochem. Int. pmid:28947342
Lee JA et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin. 2017 Pharmacol Rep pmid:28939344
Tamayose CI et al. Non-Clinical Studies for Evaluation of 8-C-Rhamnosyl Apigenin Purified from Peperomia obtusifolia against Acute Edema. 2017 Int J Mol Sci pmid:28906474
Zhang L et al. Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. 2017 Mol Med Rep pmid:28849116
Tu F et al. Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations. 2017 Med. Sci. Monit. pmid:28821706
Liu S and Ho PC Intranasal administration of brain-targeted HP-β-CD/chitosan nanoparticles for delivery of scutellarin, a compound with protective effect in cerebral ischaemia. 2017 J. Pharm. Pharmacol. pmid:28809432
Fallatah O and Georges E Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. 2017 Int. J. Antimicrob. Agents pmid:28807879
Adaszyńska-Skwirzyńska M and Dzięcioł M Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. 2017 Nat. Prod. Res. pmid:28449600
Mohammad F E et al. Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity. 2017 J. Biochem. Mol. Toxicol. pmid:28422384
Che Ahmad Tantowi NA et al. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. 2017 Menopause pmid:28640163
Feng X et al. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. 2017 Biochem. Pharmacol. pmid:28414138
Li G et al. Application of molecular imaging technology in evaluating the inhibiting effect of apigenin in vivo on subcutaneous hepatocellular carcinoma. 2017 Biochem. Biophys. Res. Commun. pmid:28408212
Li J et al. Perspectives of traditional Chinese medicine in pancreas protection for acute pancreatitis. 2017 World J. Gastroenterol. pmid:28611514
Wu W et al. Solubility and dissolution rate improvement of the inclusion complex of apigenin with 2-hydroxypropyl-β-cyclodextrin prepared using the liquid antisolvent precipitation and solvent removal combination methods. 2017 Drug Dev Ind Pharm pmid:28402147
Chen JL and Ko WC Relaxation of isolated guinea-pig trachea by apigenin, a constituent of celery, via inhibition of phosphodiesterase. 2017 Eur. J. Pharmacol. pmid:28603044
Wan Y et al. miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. 2017 Tumour Biol. pmid:28381178
Singhal SS et al. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. 2017 Biochim Biophys Acta Rev Cancer pmid:28359741
Zhang Z et al. Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system. 2017 Drug Dev Ind Pharm pmid:28358225
Han Y et al. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage. 2017 J Clin Neurosci pmid:28342702
Bian M et al. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation. 2017 Brain Res. pmid:28336272
Crascì L et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. 2017 Planta Med. pmid:28288492
Zhang S et al. Vitexin alleviates ox-LDL-mediated endothelial injury by inducing autophagy via AMPK signaling activation. 2017 Mol. Immunol. pmid:28288411
Zhao G et al. Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells. 2017 Oncol. Rep. pmid:28260058
Bolzon LB et al. Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems. 2017 J. Inorg. Biochem. pmid:28236787
Liu HJ et al. Apigenin alleviates STZ-induced diabetic cardiomyopathy. 2017 Mol. Cell. Biochem. pmid:28176247
Maher HM et al. Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS. 2017 J Pharm Biomed Anal pmid:28167419
Wei X et al. Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension. 2017 Clin. Sci. pmid:28143892
Espargaró A et al. Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs. 2017 J. Nat. Prod. pmid:28128562
Zhou Z et al. Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. 2017 Anticancer Drugs pmid:28125432
Erdogan S et al. The natural flavonoid apigenin sensitizes human CD44 prostate cancer stem cells to cisplatin therapy. 2017 Biomed. Pharmacother. pmid:28107698
Wang F et al. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. 2017 Chem. Biol. Interact. pmid:28803762
Gaballah HH et al. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms. 2017 Toxicol. Appl. Pharmacol. pmid:28025107
Sheeja Malar D et al. Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia - An in vitro and in silico study. 2017 Pharm Biol pmid:27931177
Ganai SA Plant-derived flavone Apigenin: The small-molecule with promising activity against therapeutically resistant prostate cancer. 2017 Biomed. Pharmacother. pmid:27930986
Hithamani G et al. Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells. 2017 J. Biosci. pmid:29229878
Tseng TH et al. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21 expression. 2017 Environ. Toxicol. pmid:26872304
Zou Z et al. Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii. 2017 Fitoterapia pmid:27889540
Zou Z et al. Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii. 2017 Phytochemistry pmid:27889245
Ketkaew Y et al. Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line. 2017 Arch. Oral Biol. pmid:27886571
Liu H et al. Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study. 2017 J Chromatogr Sci pmid:27884870
Wu CY et al. Scutellarin Attenuates Microglia-Mediated Neuroinflammation and Promotes Astrogliosis in Cerebral Ischemia - A Therapeutic Consideration. 2017 Curr. Med. Chem. pmid:27855618
Guo TT et al. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. 2017 J Asian Nat Prod Res pmid:27848262
Sharma N et al. Elucidation of Antiangiogenic Potential of Vitexin Obtained from Cucumis sativus Targeting Hsp90 Protein: A Novel Multipathway Targeted Approach to Restrain Angiogenic Phenomena. 2017 Med Chem pmid:27834134
Tang D et al. Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. 2017 Expert Opin Drug Metab Toxicol pmid:27766890
Wen L et al. Identification of a flavonoid C-glycoside as potent antioxidant. 2017 Free Radic. Biol. Med. pmid:28587909
Oliveira KG et al. Effect of the storage time and temperature on phenolic compounds of sorghum grain and flour. 2017 Food Chem pmid:27596435
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117
Wong TY et al. Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet. 2017 Biomed. Pharmacother. pmid:29198743
Salazar-Aguilar S et al. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. 2017 Nutrients pmid:28757593