apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhang GH et al. | The anti-HIV-1 effect of scutellarin. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16023998 |
Steyns JM and van Brederode J | Variation in the substrate specificity of allozymes catalyzing flavone-O-glucoside biosynthesis in Silene plants. | 1986 | Biochem. Genet. | pmid:2943268 |
Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
Sarno S et al. | Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). | 2003 | Biochem. J. | pmid:12816539 |
Llorens F et al. | The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function. | 2006 | Biochem. J. | pmid:16225457 |
Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
Avallone R et al. | Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | Biochem. Pharmacol. | pmid:10751547 |
Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
López-Posadas R et al. | Effect of flavonoids on rat splenocytes, a structure-activity relationship study. | 2008 | Biochem. Pharmacol. | pmid:18590707 |
Chen Y et al. | Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9. | 2008 | Biochem. Pharmacol. | pmid:18565494 |
Feng X et al. | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Biochem. Pharmacol. | pmid:28414138 |
Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
van Meeteren ME et al. | Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease. | 2004 | Biochem. Pharmacol. | pmid:15104250 |
Mandery K et al. | Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. | 2010 | Biochem. Pharmacol. | pmid:20797388 |
Fesen MR et al. | Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. | 1994 | Biochem. Pharmacol. | pmid:7520698 |
Verbeek R et al. | Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. | 2005 | Biochem. Pharmacol. | pmid:15946653 |
Ko WC et al. | Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | 2004 | Biochem. Pharmacol. | pmid:15476679 |
Liu Y et al. | Effects of the natural flavone trimethylapigenin on cardiac potassium currents. | 2012 | Biochem. Pharmacol. | pmid:22583923 |
Laberge RM et al. | Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. | 2007 | Biochem. Pharmacol. | pmid:17359940 |
Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |