apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Palmieri D et al. | Estrogen receptor activation protects against TNF-α-induced endothelial dysfunction. | 2014 | Angiology | pmid:23427281 |
Pei Y et al. | Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality. | 2018 | Anim. Sci. J. | pmid:29708294 |
Mendel M et al. | Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study. | 2016 | Animal | pmid:27534882 |
Li N et al. | A possible quantitative method to improve the sensitivity of scutellarin in human plasma. | 2005 | Ann Chim | pmid:16136842 |
Agati G et al. | Mesophyll distribution of 'antioxidant' flavonoid glycosides in Ligustrum vulgare leaves under contrasting sunlight irradiance. | 2009 | Ann. Bot. | pmid:19633310 |
Ganesan K and Xu B | Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. | 2017 | Ann. N. Y. Acad. Sci. | pmid:28891090 |
Huang ST et al. | Inhibitory effects of a rice hull constituent on tumor necrosis factor alpha, prostaglandin E2, and cyclooxygenase-2 production in lipopolysaccharide-activated mouse macrophages. | 2005 | Ann. N. Y. Acad. Sci. | pmid:15965085 |
Meyer H et al. | Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | Ann. Nutr. Metab. | pmid:16407641 |
Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
Seydi E et al. | Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria. | 2016 | Anticancer Agents Med Chem | pmid:27109019 |