apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Iwashina T et al. | Analysis of flavonoids in pubescence of soybean near-isogenic lines for pubescence color loci. | J. Hered. | pmid:16985083 | |
Chockalingam S et al. | Biogenesis, characterization, and the effect of vicenin-gold nanoparticles on glucose utilization in 3T3-L1 adipocytes: a bioinformatic approach to illuminate its interaction with PTP 1B and AMPK. | Biotechnol. Prog. | pmid:26014104 | |
pmid:28024940 | ||||
Deepak M et al. | Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC. | Phytochem Anal | pmid:15688952 | |
Greenham J et al. | Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. | Phytochem Anal | pmid:12693635 | |
Bai H et al. | Apigenin induced MCF-7 cell apoptosis-associated reactive oxygen species. | Scanning | pmid:25327419 | |
Zhang J et al. | The potential application of strategic released apigenin from polymeric carrier in pulmonary fibrosis. | Exp. Lung Res. | pmid:29206498 | |
Utispan K et al. | Propolis Extracted from the Stingless Bee Trigona sirindhornae Inhibited S. mutans Activity In Vitro. | Oral Health Prev Dent | pmid:28674707 | |
Guan Z et al. | Identification and quantitation of phenolic compounds from the seed and pomace of Perilla frutescens using HPLC/PDA and HPLC-ESI/QTOF/MS/MS. | Phytochem Anal | pmid:24737524 | |
pmid:15360311 | ||||
Zam W and Khadour A | Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer. | Nutr Cancer | pmid:28094554 | |
Stanisavljević NS et al. | Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativum L.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities. | Nutr Cancer | pmid:27348025 | |
Barros GO et al. | Phenolics removal from transgenic Lemna minor extracts expressing mAb and impact on mAb production cost. | Biotechnol. Prog. | pmid:21485031 | |
Galicka A et al. | Differential effect of flavonoids on glycosaminoglycan content and distribution in skin fibroblasts of patients with type I osteogenesis imperfecta. | Mol Med Rep | pmid:21472276 | |
pmid: | ||||
pmid:21176927 | ||||
Choudhary MI et al. | Hemiterpene glucosides and other constituents from Spiraea canescens. | Phytochemistry | pmid:19747701 | |
Guo X et al. | Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. | Obes Res Clin Pract | pmid:26314502 | |
pmid:22949589 | ||||
McEWEN WK | Steric deformation; the synthesis of N-methyl etioporphyrin. | 1946 | J. Am. Chem. Soc. | pmid:21022260 |