apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tian Y et al. | [The effect of apigenin on reproductive axis in female rats]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21845881 |
Pang LL et al. | [Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice]. | 2010 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20669675 |
Guo LL et al. | [Effect of scutellarin on expressions of nicotinic acetylcholine receptor protein and mRNA in the brains of dementia rats]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:21823425 |
Sang SM et al. | [Studies on the flavonol glycosides from the seeds of Vaccaria segetalis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512436 |
Zhang WD et al. | [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516462 |
Zhang J et al. | [Studies on chemical constituents of leaves of Salix matsudana Koidz and their influence on lipolysis]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12516463 |
Yang SC et al. | [Study on optimal harvest time of Erigeron breviscapus]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260301 |
Wang XM et al. | [HPLC determination of four active components in dengzhanxixin injection]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18841764 |
Zhang Y et al. | [Effect of water stress on content of active constituents in Erigeron breviscaps]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19673373 |
Hu YM et al. | [Flavones from flowers of Sesamum indicum]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583201 |
Wang WS et al. | [Studies on the flavonoids in herb from Scutellaria barbata]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631081 |
Tian J et al. | [Studies on the chemical constitutents in herb of Verbena officinalis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15724402 |
Gu HF et al. | [Studies on chemical constituents from herb of Dracocephalum moldavica]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706847 |
Su J et al. | [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706914 |
Zhu XX et al. | [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16780160 |
Qin S and Wen X | [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22779181 |
He CH et al. | [Study on intestinal absorption kinetics of apigenin in rats]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23944080 |
Li XB et al. | [Simultaneous determination of chlorogenic acid, scutellarin, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid in different parts of Erigeron breviscapus by high-performance liquid chromatography]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24199546 |
Liu T et al. | [Relationship between expression of chalcone synthase gene (CHS) and scutellarin content in Erigeron breviscapus]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:24199547 |
Wu QP et al. | [Determination of five primary chemical constituents in Cassia angustifolia by HPLC]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533485 |