apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with apigenin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Silfen J et al. | Bioflavonoid effects on in vitro cultures of Plasmodium falciparum. Inhibition of permeation pathways induced in the host cell membrane by the intraerythrocytic parasite. | 1988 | Biochem. Pharmacol. | pmid:3058128 |
Occhiuto F et al. | Study on the action mechanism of some flavones through registration of intracardiac potentials in anesthetized dogs. | 1988 | Pharmacol Res Commun | pmid:3211997 |
Chen ZN et al. | [Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb]. | 1988 | Yao Xue Xue Bao | pmid:3257032 |
Barberan FA et al. | Isoscutellarein-7-O-[allosyl (1----2) glucoside] from Sideritis leucantha. | 1985 Jan-Feb | J. Nat. Prod. | pmid:4009184 |
Ciaceri G and Attaguile G | [Influence of luteoline, apigenine and acacetine on experimental gastric ulcer]. | 1972 | Minerva Med. | pmid:5025773 |
Della Loggia R et al. | [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. | 1981 Sep-Oct | Riv Neurol | pmid:6118937 |
Fourie TG and Snyckers FO | A flavone with antiinflammatory activity from the roots of Rhus undulata. | 1984 Nov-Dec | J. Nat. Prod. | pmid:6241941 |
Matern U et al. | Conformational changes of apigenin 7-O-(6-O-malonylglucoside), a vacuolar pigment from parsley, with solvent composition and proton concentration. | 1983 | Eur. J. Biochem. | pmid:6303788 |
Oksüz S et al. | 6-Methoxylated and C-glycosyl flavonoids from Centaurea species. | 1984 Sep-Oct | J. Nat. Prod. | pmid:6512542 |
Li LD et al. | Studies on hawthorn and its active principle. II. Effects on cultured rat heart cells deprived of oxygen and glucose. | 1984 | J Tradit Chin Med | pmid:6570503 |