apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with apigenin?
Related references are published most in these journals:
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What lipids are associated with apigenin?
Related references are published most in these journals:
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu W et al. | Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique. | 2017 | Drug Deliv | pmid:29115900 |
| Tu F et al. | Angiogenic effects of apigenin on endothelial cells after hypoxia-reoxygenation via the caveolin-1 pathway. | 2017 | Int. J. Mol. Med. | pmid:29039442 |
| Dang Y et al. | Protective effects of apigenin against acrylonitrile-induced subchronic sperm injury in rats. | 2017 | Food Chem. Toxicol. | pmid:28963002 |
| Agah S et al. | Complementary cereals and legumes for health: Synergistic interaction of sorghum flavones and cowpea flavonols against LPS-induced inflammation in colonic myofibroblasts. | 2017 | Mol Nutr Food Res | pmid:28155259 |
| Nurdiana S et al. | Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. | 2017 | BMC Complement Altern Med | pmid:28576138 |
| Bauer D et al. | Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. | 2017 | PLoS ONE | pmid:28441391 |
| Meng S et al. | Apigenin inhibits renal cell carcinoma cell proliferation. | 2017 | Oncotarget | pmid:28423637 |
| Wang N et al. | Apigenin attenuates streptozotocin-induced pancreatic β cell damage by its protective effects on cellular antioxidant defense. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28181104 |
| Zhang L et al. | Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling. | 2017 | J. Mol. Recognit. | pmid:28058739 |
| Hou L et al. | Scutellarin Inhibits Proliferation, Invasion, and Tumorigenicity in Human Breast Cancer Cells by Regulating HIPPO-YAP Signaling Pathway. | 2017 | Med. Sci. Monit. | pmid:29079722 |
| Malik S et al. | Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-κB-TNF-α and TGF-β1-MAPK-fibronectin pathways. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566504 |
| Yao HM et al. | [Effects of apigenin on lipopolysaccharide induced proliferation of rat aortic vascular smooth muscle cells]. | 2017 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:28545285 |
| Fernandes LM et al. | Genotoxicity and Antigenotoxicity Assessments of the Flavonoid Vitexin by the Drosophila melanogaster Somatic Mutation and Recombination Test. | 2017 | J Med Food | pmid:28541831 |
| Lin CM et al. | Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. | 2017 | Sci Rep | pmid:28337019 |
| Pápay ZE et al. | Study on the Pulmonary Delivery System of Apigenin-Loaded Albumin Nanocarriers with Antioxidant Activity. | 2017 | J Aerosol Med Pulm Drug Deliv | pmid:28282259 |
| Rašković A et al. | Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. | 2017 | Eur J Drug Metab Pharmacokinet | pmid:28255865 |
| Li Y et al. | Pharmacokinetic Study of Swertisin by HPLC-MS/MS After Intravenous Administration in Rats. | 2017 | J Chromatogr Sci | pmid:27993862 |
| Wang B and Zhao XH | Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells. | 2017 | Oncol. Rep. | pmid:27959417 |
| Lecomte S et al. | Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28396216 |
| Oh HK et al. | Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. | 2017 | J. Psychopharmacol. (Oxford) | pmid:27729563 |