| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
apigenin
apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.
Cross Reference
Introduction
To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with apigenin?
apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with apigenin
PubChem Associated disorders and diseases
What pathways are associated with apigenin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with apigenin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with apigenin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with apigenin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with apigenin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with apigenin?
Mouse Model
Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).
Tissue Model
Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with apigenin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Aljancić I et al. | Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity. | 1999 | J. Nat. Prod. | pmid:10395518 |
| Jeong HJ et al. | Inhibition of aromatase activity by flavonoids. | 1999 | Arch. Pharm. Res. | pmid:10403137 |
| Takasaki M et al. | Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. | 1999 | J. Nat. Prod. | pmid:10425119 |
| Afifi FU et al. | Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. | 1999 | J Ethnopharmacol | pmid:10465658 |
| Dekermendjian K et al. | Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex. | 1999 | J. Med. Chem. | pmid:10543878 |
| Yin F et al. | Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). | 1999 Sep-Oct | Anticancer Res. | pmid:10628390 |
| Breinholt V et al. | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. | 1999 | Xenobiotica | pmid:10647909 |
| Galijatovic A et al. | Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. | 1999 | Xenobiotica | pmid:10647910 |
| Segaert S et al. | The flavonoid apigenin suppresses vitamin D receptor expression and vitamin D responsiveness in normal human keratinocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652242 |
| Chan EC et al. | Relaxation to flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure-activity relationships. | 2000 | J. Cardiovasc. Pharmacol. | pmid:10672869 |
| Wang IK et al. | Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. | 1999 | Eur. J. Cancer | pmid:10673981 |
| Pieroni A and Pachaly P | Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L. | 2000 | Pharmazie | pmid:10683879 |
| Trochon V et al. | Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression. | 2000 | Int. J. Cancer | pmid:10699950 |
| Nakazawa T and Ohsawa K | Metabolites of orally administered Perilla frutescens extract in rats and humans. | 2000 | Biol. Pharm. Bull. | pmid:10706426 |
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| O'Gorman DM et al. | Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. | 2000 | Leukemia | pmid:10764145 |
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| Pieroni A et al. | Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae). | 2000 | J Ethnopharmacol | pmid:10837985 |
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| Caltagirone S et al. | Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. | 2000 | Int. J. Cancer | pmid:10918203 |
| Yoshikawa M et al. | Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside. | 2000 | Chem. Pharm. Bull. | pmid:10923837 |
| Ecay TW et al. | Wortmannin inhibition of forskolin-stimulated chloride secretion by T84 cells. | 2000 | Biochim. Biophys. Acta | pmid:10930508 |
| Zanoli P et al. | Behavioral characterisation of the flavonoids apigenin and chrysin. | 2000 | Fitoterapia | pmid:10930722 |
| Breinholt V et al. | Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. | 2000 | Food Chem. Toxicol. | pmid:10942316 |
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| Wang CN et al. | The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. | 2001 | J. Biol. Chem. | pmid:11083861 |
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| Galati G et al. | Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. | 2001 | Free Radic. Biol. Med. | pmid:11182292 |
| de Santi C et al. | Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. | 2000 | Xenobiotica | pmid:11197066 |
| Greenham J et al. | A distinctive flavonoid chemistry for the anomalous genus Biebersteinia. | 2001 | Phytochemistry | pmid:11198823 |
| Carini M et al. | LC coupled to ion-trap MS for the rapid screening and detection of polyphenol antioxidants from Helichrysum stoechas. | 2001 | J Pharm Biomed Anal | pmid:11199231 |
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| Ashida H | Suppressive effects of flavonoids on dioxin toxicity. | 2000 | Biofactors | pmid:11216487 |
| Heijnen CG et al. | Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. | 2001 | Toxicol In Vitro | pmid:11259863 |
| Mitchell KA et al. | Flavonoid characters contributing to the taxonomic revision of the Hebe parviflora complex. | 2001 | Phytochemistry | pmid:11261578 |
| Stochmal A et al. | Alfalfa (Medicago sativa L.) flavonoids. 1. Apigenin and luteolin glycosides from aerial parts. | 2001 | J. Agric. Food Chem. | pmid:11262024 |
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| Hanyaloglu AC et al. | Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to beta-arrestin-dependent internalization. | 2001 | J. Biol. Chem. | pmid:11278484 |
| Yin F et al. | Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. | 2001 Jan-Feb | Anticancer Res. | pmid:11299771 |
| Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
| Casagrande F and Darbon JM | Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. | 2001 | Biochem. Pharmacol. | pmid:11322924 |
| Liang YC et al. | Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. | 2001 | FEBS Lett. | pmid:11343698 |
| Griffith AP and Collison MW | Improved methods for the extraction and analysis of isoflavones from soy-containing foods and nutritional supplements by reversed-phase high-performance liquid chromatography and liquid chromatography-mass spectrometry. | 2001 | J Chromatogr A | pmid:11355838 |
| Huang X et al. | 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors. | 2001 | J. Med. Chem. | pmid:11384234 |
| Nejaty H et al. | Differing effects of endocrine-disrupting chemicals on basal and FSH-stimulated progesterone production in rat granulosa-luteal cells. | 2001 | Exp. Biol. Med. (Maywood) | pmid:11395928 |
| Fischer H et al. | Partial restoration of defective chloride conductance in DeltaF508 CF mice by trimethylamine oxide. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11404245 |
| Miean KH and Mohamed S | Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. | 2001 | J. Agric. Food Chem. | pmid:11410016 |
| Tammi R et al. | Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. | 2001 | J. Biol. Chem. | pmid:11451952 |
| Stochmal A et al. | Acylated apigenin glycosides from alfalfa (Medicago sativa L.) var. Artal. | 2001 | Phytochemistry | pmid:11454348 |
| Allen SW et al. | The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. | 2001 | Drug Metab. Dispos. | pmid:11454723 |
| Oberdörster E et al. | Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones. | 2001 | J. Steroid Biochem. Mol. Biol. | pmid:11457661 |
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| Matławska I | Flavonoid compounds in the flowers of Kitaibelia vitifolia Willd. (Malvaceae). | 2001 Mar-Apr | Acta Pol Pharm | pmid:11501790 |
| Gobbi M et al. | In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. | 2001 | Pharmacopsychiatry | pmid:11518075 |
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| Gupta S et al. | Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573952 |
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| McVean M et al. | A p21(waf1)-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34(cdc2) and concomitant G(2)/M arrest by the chemopreventive flavonoid apigenin. | 2002 | Mol. Carcinog. | pmid:11807956 |
| Tatsuta A et al. | Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. | 2000 | Clin. Exp. Metastasis | pmid:11827069 |
| Landesman-Bollag E et al. | Protein kinase CK2: signaling and tumorigenesis in the mammary gland. | 2001 | Mol. Cell. Biochem. | pmid:11827167 |
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| Frangne N et al. | Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. | 2002 | Plant Physiol. | pmid:11842175 |
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