apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Rodriguez IF et al. Morphological, histological, chemical and functional characterization of Prosopis alba flours of different particle sizes. 2019 Food Chem pmid:30372982
Li ZM et al. Vitexin alleviates streptozotocin-induced sexual dysfunction and fertility impairments in male mice via modulating the hypothalamus-pituitary-gonadal axis. 2019 Chem. Biol. Interact. pmid:30365938
Brauch D et al. Changes in isovitexin-O-glycosylation during the development of young barley plants. 2018 Phytochemistry pmid:29421507
Baruah TJ et al. Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells. 2018 Mol. Biol. Rep. pmid:30099686
Sun Q et al. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. 2018 Biochem. Biophys. Res. Commun. pmid:29408335
Chen S et al. A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Extract. 2018 Molecules pmid:30037063
Ling T et al. Novel vitexin-inspired scaffold against leukemia. 2018 Eur J Med Chem pmid:29407975
Yang M et al. Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. 2018 Biomed. Pharmacother. pmid:30021365
Ashokkumar R et al. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. 2018 Biochem. Biophys. Res. Commun. pmid:29406244
van Dooren I et al. In vitro gastrointestinal biotransformation and characterization of a Desmodium adscendens decoction: the first step in unravelling its behaviour in the human body. 2018 J. Pharm. Pharmacol. pmid:30003542
Liu X et al. Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches. 2018 Nat Commun pmid:29386648
Okitsu N et al. Identification and Characterization of Novel Nemophila menziesii Flavone Glucosyltransferases that Catalyze Biosynthesis of Flavone 7,4'-O-Diglucoside, a Key Component of Blue Metalloanthocyanins. 2018 Plant Cell Physiol. pmid:29986079
Mekawy AMM et al. Apigenin pretreatment enhances growth and salinity tolerance of rice seedlings. 2018 Plant Physiol. Biochem. pmid:29980098
Lorizola IM et al. Beet Stalks and Leaves ( L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. 2018 Nutrients pmid:29976910
Gao AM et al. Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis. 2018 Chem. Biol. Interact. pmid:29191453
Zhang Y et al. Apigenin suppresses mouse peritoneal fibrosis by down-regulating miR34a expression. 2018 Biomed. Pharmacother. pmid:29966983
Wong TY et al. Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. 2018 J. Pharm. Pharmacol. pmid:29943490
Bai HH et al. Hydroxycinnamoylmalated flavone C-glycosides from Lemna japonica. 2018 Fitoterapia pmid:29154864
Jiang PY et al. Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway. 2018 Microb. Pathog. pmid:29928944
Zhou Z et al. Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. 2018 Mol Med Rep pmid:29901074
Yang D et al. Vicenin-2 inhibits Wnt/β-catenin signaling and induces apoptosis in HT-29 human colon cancer cell line. 2018 Drug Des Devel Ther pmid:29849451
Bhattacharya S et al. Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. 2018 Nanomedicine pmid:29802937
Gu CB et al. Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]. 2018 J. Appl. Microbiol. pmid:29791772
Zhu J et al. Protective effects of Hand.- Mazz. (EBHM) extract in retinal neurodegeneration models. 2018 Mol. Vis. pmid:29769797
Amiri M et al. Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. 2018 Phytother Res pmid:29748995
Oliveira DR et al. Flavones-bound in benzodiazepine site on GABA receptor: Concomitant anxiolytic-like and cognitive-enhancing effects produced by Isovitexin and 6-C-glycoside-Diosmetin. 2018 Eur. J. Pharmacol. pmid:29738701
Dang Y et al. Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF-κB Pathway in Rats. 2018 Inflammation pmid:29687413
You P et al. Scutellarin suppresses neuroinflammation via the inhibition of the AKT/NF-κB and p38/JNK pathway in LPS-induced BV-2 microglial cells. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29680917
Yang J et al. Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. 2018 Biomed. Pharmacother. pmid:29680738
Hu JJ et al. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation. 2018 Microb. Pathog. pmid:29604422
Vrhovac Madunić I et al. Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29541820
Zhang X et al. Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. 2018 Free Radic. Res. pmid:29400110
Kim A and Lee CS Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mTOR, JNK, and p38-MAPK. 2018 Naunyn Schmiedebergs Arch. Pharmacol. pmid:29264665
Radulovic K et al. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. 2018 Mucosal Immunol pmid:29139477
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Nabavi SF et al. Apigenin as neuroprotective agent: Of mice and men. 2018 Pharmacol. Res. pmid:29055745
Abu Bakar AR et al. Experimental and computational approaches to reveal the potential of Ficus deltoidea leaves extract as α-amylase inhibitor. 2018 Nat. Prod. Res. pmid:28391727
Ren K et al. Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing Inflammation. 2018 Cell. Physiol. Biochem. pmid:29975943
Xia Y et al. Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. 2018 J. Agric. Food Chem. pmid:29945448
Wang J et al. Scutellarin enhances osteoblast proliferation and function via NF-κB-mediated CXCR4 induction. 2018 Gene pmid:29936266
Wong TY et al. Traversal of the Blood-Brain Barrier by Cleavable l-Lysine Conjugates of Apigenin. 2018 J. Agric. Food Chem. pmid:29923397
Šarić Mustapić D et al. The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. 2018 Molecules pmid:30301254
Ravisankar S et al. Structural profile of soluble and bound phenolic compounds in teff (Eragrostis tef) reveals abundance of distinctly different flavones in white and brown varieties. 2018 Food Chem pmid:29784316
Lim H et al. Flavonoids interfere with NLRP3 inflammasome activation. 2018 Toxicol. Appl. Pharmacol. pmid:29960001
Malar DS et al. Grewia tiliaefolia and its active compound vitexin regulate the expression of glutamate transporters and protect Neuro-2a cells from glutamate toxicity. 2018 Life Sci. pmid:29704481
Hadrich F and Sayadi S Apigetrin inhibits adipogenesis in 3T3-L1 cells by downregulating PPARγ and CEBP-α. 2018 Lipids Health Dis pmid:29695233
Lu Y et al. Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway. 2018 PLoS ONE pmid:29694408
Gurunathan S et al. Antibacterial Efficacy of Silver Nanoparticles on Endometritis Caused by and in Dairy Cattle. 2018 Int J Mol Sci pmid:29659523
Karamać M et al. Phenolic contents and antioxidant capacities of wild and cultivated white lupin (Lupinus albus L.) seeds. 2018 Food Chem pmid:29655709
Mo J et al. Scutellarin protects against vascular endothelial dysfunction and prevents atherosclerosis via antioxidation. 2018 Phytomedicine pmid:29655699
Kumar KS et al. Isolation, identification and characterization of apigenin from Justicia gendarussa and its anti-inflammatory activity. 2018 Int. Immunopharmacol. pmid:29655057
Paredes MD et al. Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats. 2018 Nutrients pmid:29652818
Zeng YQ et al. Scutellarin Mitigates Aβ-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. 2018 Molecules pmid:29642616
Gentile D et al. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. 2018 PLoS ONE pmid:29641549
Kalogiouri NP et al. Application of an advanced and wide scope non-target screening workflow with LC-ESI-QTOF-MS and chemometrics for the classification of the Greek olive oil varieties. 2018 Food Chem pmid:29606472
Hu WJ et al. Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling. 2018 Biomed. Pharmacother. pmid:29604587
Hu M et al. Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway. 2018 Drug Des Devel Ther pmid:29588573
Elhennawy MG and Lin HS Dose- and time-dependent pharmacokinetics of apigenin trimethyl ether. 2018 Eur J Pharm Sci pmid:29574080
Malar DS et al. Vitexin inhibits Aβ induced toxicity in Neuro-2a cells by augmenting Nrf-2/HO-1 dependent antioxidant pathway and regulating lipid homeostasis by the activation of LXR-α. 2018 Toxicol In Vitro pmid:29545167
Yang YC and Wei MC Development and characterization of a green procedure for apigenin extraction from Scutellaria barbata D. Don. 2018 Food Chem pmid:29478557
Witkowska-Banaszczak E Flavonoids from Trollius europaeus flowers and evaluation of their biological activity. 2018 J. Pharm. Pharmacol. pmid:29466602
Chledzik S et al. Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron: A Systematic Review. 2018 Am. J. Chin. Med. pmid:29433387
Zhu Q et al. Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. 2018 Steroids pmid:29425740
Tao Y et al. Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC-MS/MS approaches. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29428673
Srivastava A et al. Swertisin ameliorates diabetes by triggering pancreatic progenitors for islet neogenesis in Streptozotocin treated BALB/c mice. 2018 Biomed. Pharmacother. pmid:29428671
Melguizo-Rodríguez L et al. Effect of olive oil phenolic compounds on osteoblast differentiation. 2018 Eur. J. Clin. Invest. pmid:29392706
Jin UH et al. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. 2018 Toxicol. Sci. pmid:29584932
Ni G et al. Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. 2018 Molecules pmid:29389889
Rimal H et al. Hydroxylation of Resveratrol with DoxA In Vitro: An Enzyme with the Potential for the Bioconversion of a Bioactive Stilbene. 2018 J. Microbiol. Biotechnol. pmid:29385664
Zhang G et al. Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. 2018 Mol Med Rep pmid:29328424
Madunić J et al. Apigenin: A dietary flavonoid with diverse anticancer properties. 2018 Cancer Lett. pmid:29097249
Venturini CL et al. Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma. 2018 Biomed. Pharmacother. pmid:29091859
Yang B et al. Pharmacokinetic comparison of seven major bioactive components in normal and depression model rats after oral administration of Baihe Zhimu decoction by liquid chromatography-tandem mass spectrometry. 2018 J Pharm Biomed Anal pmid:28987996
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Zhong Y et al. Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring. 2018 Med Chem pmid:28875860
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Gaspar MC et al. Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. 2018 Nat. Prod. Res. pmid:28627294
Zengin G et al. Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays. 2018 Fundam Clin Pharmacol pmid:29505673
Bougioukas I et al. Apigenin Reduces NF-κB and Subsequent Cytokine Production as Protective Effect in a Rodent Animal Model of Lung Ischemia-Reperfusion Injury. 2018 J Invest Surg pmid:28340319
Gadioli IL et al. A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. 2018 Crit Rev Food Sci Nutr pmid:27645583
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Xin Z et al. UPLC-Orbitrap-MS/MS combined with chemometrics establishes variations in chemical components in green tea from Yunnan and Hunan origins. 2018 Food Chem pmid:30381222
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
Cornara L et al. Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. 2018 Int. J. Legal Med. pmid:29362872
Cheruvu HS et al. LC-MS/MS method for the simultaneous quantification of luteolin, wedelolactone and apigenin in mice plasma using hansen solubility parameters for liquid-liquid extraction: Application to pharmacokinetics of Eclipta alba chloroform fraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29518720
Chassagne F et al. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. 2018 Fitoterapia pmid:29477305
van Vugt-Lussenburg BMA et al. Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity. 2018 Reprod. Toxicol. pmid:29162470
Zhong Y et al. Protective effects of apigenin against 3-MCPD-induced renal injury in rat. 2018 Chem. Biol. Interact. pmid:30107153
Xu L et al. Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects. 2018 J. Exp. Clin. Cancer Res. pmid:30373602
Vieira FN et al. Long-Term Effect on Bioactive Components and Antioxidant Activity of Thermal and High-Pressure Pasteurization of Orange Juice. 2018 Molecules pmid:30347848
Wang X et al. Effect of apigenin on apoptosis induced by renal ischemia/reperfusion injury in vivo and in vitro. 2018 Ren Fail pmid:30278824
Han T et al. Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. 2018 Eur J Med Chem pmid:30243153
Ojo OA et al. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. 2018 J Basic Clin Physiol Pharmacol pmid:29381472
Thangaiyan R et al. Preventive effect of apigenin against isoproterenol-induced apoptosis in cardiomyoblasts. 2018 J. Biochem. Mol. Toxicol. pmid:30152906
Shin JW et al. Scutellarin Ameliorates Learning and Memory Deficit via Suppressing [Formula: see text]-Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion. 2018 Am. J. Chin. Med. pmid:30149759
Kim HJ et al. Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition. 2018 Am. J. Chin. Med. pmid:30149756
Feng X et al. Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. 2018 Molecules pmid:30149616
Kang CH et al. Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation. 2018 Food Chem. Toxicol. pmid:29247770
Makanjuola SBL et al. Apigenin and apigeninidin isolates from the Sorghum bicolor leaf targets inflammation via cyclo-oxygenase-2 and prostaglandin-E blockade. 2018 Int J Rheum Dis pmid:30146750