apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

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Introduction

To understand associated biological information of apigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with apigenin?

apigenin is suspected in Pneumonia, Morphologically altered structure, Hypertensive disease, Dermatitis, Infection, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with apigenin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Per page 10 20 50 100 | Total 64

PubChem Associated disorders and diseases

What pathways are associated with apigenin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with apigenin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with apigenin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with apigenin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with apigenin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with apigenin?

Mouse Model

Mouse Model are used in the study 'Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.' (Nicholas C et al., 2007), Mouse Model are used in the study 'Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study.' (Kaur P et al., 2008) and Mouse Model are used in the study 'Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.' (Dong J et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma.' (Torkin R et al., 2005).

Tissue Model

Tissue Model are used in the study 'Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.' (Lim R et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with apigenin

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Per page 10 20 50 100 | Total 2777
Authors Title Published Journal PubMed Link
Muhammad AA et al. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. 2016 Drug Des Devel Ther pmid:27307703
Xie Y et al. Preparative Separation and Purification of the Total Flavonoids in Scorzonera austriaca with Macroporous Resins. 2016 Molecules pmid:27304948
Peng HY et al. Apigenin-7-O-β-D-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens. 2016 J Zhejiang Univ Sci B pmid:27256678
Jung UJ et al. Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice. 2016 Nutrients pmid:27213439
Wakx A et al. New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. 2016 Toxicol In Vitro pmid:26657896
Kim A et al. Apigenin Reduces Proteasome Inhibition-Induced Neuronal Apoptosis by Suppressing the Cell Death Process. 2016 Neurochem. Res. pmid:27473386
He X et al. Protective role of apigenin in cisplatin-induced renal injury. 2016 Eur. J. Pharmacol. pmid:27388142
Coombs MR et al. Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells. 2016 Cancer Lett. pmid:27378243
Velikova V et al. Physiological significance of isoprenoids and phenylpropanoids in drought response of Arundinoideae species with contrasting habitats and metabolism. 2016 Plant Cell Environ. pmid:27351898
Kesavan R et al. Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. 2016 Nutr Metab Cardiovasc Dis pmid:26868432
Abugri DA et al. In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii. 2016 Exp. Parasitol. pmid:26855040
Weng L et al. Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice. 2016 Eur. J. Pharmacol. pmid:26826594
Dong ZX et al. Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism In Vivo. 2016 Chem Biol Drug Des pmid:26808289
Chen C et al. Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury. 2016 J. Cardiovasc. Pharmacol. pmid:26466327
Rosa SI et al. Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. 2016 Phytomedicine pmid:26902402
de Santana Aquino DF et al. Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. 2015 Inflammation pmid:26045342
Yin Q et al. In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. 2015 Gynecol. Endocrinol. pmid:26036805
Liu X et al. Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. 2015 Oncol. Rep. pmid:26035210
Supuran CT Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation. 2015 Expert Opin Ther Pat pmid:26028186
Zhang T et al. Apigenin protects blood-brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats. 2015 Int. Immunopharmacol. pmid:26028151
Su ZR et al. Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin. 2015 Bioorg. Med. Chem. Lett. pmid:26022844
Boudjelal A et al. Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats. 2015 Planta Med. pmid:26018915
Chang CY et al. Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. 2015 Eur. J. Pharmacol. pmid:26007643
Zhang X et al. Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. 2015 Mol. Cell. Biochem. pmid:25994505
Wong TY et al. The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. 2015 Br. J. Nutr. pmid:25978649
Banerjee K et al. Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. 2015 J Colloid Interface Sci pmid:25965432
Mastantuono T et al. Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation. 2015 Microcirculation pmid:25944567
Sang ZP et al. Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. 2015 Chem Biol Drug Des pmid:25941042
Seo HS et al. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. 2015 Mol Med Rep pmid:25936427
Chen YJ et al. Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery. 2015 Chin J Nat Med pmid:25908623
Paredes-Gonzalez X et al. Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. 2015 Biopharm Drug Dispos pmid:25904312
Li Y et al. Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. 2015 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25902051
Wang Q et al. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. 2015 Int. Immunopharmacol. pmid:25899084
Mustapha N et al. Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. 2015 Biomed. Pharmacother. pmid:25661350
Mascaraque C et al. Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. 2015 Br. J. Nutr. pmid:25654996
Costa G et al. Flavan hetero-dimers in the Cymbopogon citratus infusion tannin fraction and their contribution to the antioxidant activity. 2015 Food Funct pmid:25652784
Arango D et al. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. 2015 Mol Nutr Food Res pmid:25641956
Sang Z et al. Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. 2015 Bioorg. Med. Chem. pmid:25614117
Xiong F et al. Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects. 2015 J Ethnopharmacol pmid:25614108
Gidaro MC et al. Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products. 2015 Planta Med. pmid:25590364
María Landete J et al. Effect of soaking and fermentation on content of phenolic compounds of soybean (Glycine max cv. Merit) and mung beans (Vigna radiata [L] Wilczek). 2015 Int J Food Sci Nutr pmid:25582183
Tang H et al. Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. 2015 Arch. Pharm. Res. pmid:25577334
Del Turco S et al. Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements. 2015 Food Chem pmid:25577111
Guzelmeric E et al. Development and validation of an HPTLC method for apigenin 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like materials. 2015 J Pharm Biomed Anal pmid:25575175
Liu W et al. Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. 2015 Int. J. Mol. Med. pmid:25573459
Yu XD et al. Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors. 2015 J Ethnopharmacol pmid:25557028
Yang L et al. Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: implications on sorghum-derived phytoestrogens. 2015 Food Funct pmid:25553799
Suh YA et al. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. 2015 Int. J. Oncol. pmid:25544427
Russo D et al. Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. 2015 Nat. Prod. Res. pmid:25533266
Djouossi MG et al. Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae). 2015 BMC Complement Altern Med pmid:25928352
Heredia-Vieira SC et al. Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. 2015 J. Nat. Prod. pmid:25517504
Li LH et al. Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. 2015 Int J Clin Exp Pathol pmid:26722444
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309
Hasnat MA et al. Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. 2015 Molecules pmid:26633318
Zhu Y et al. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. 2015 Mol Med Rep pmid:25351792
Lee JA et al. Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. 2015 Nutrients pmid:26610561
Liu J et al. Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. 2015 Mol Med Rep pmid:25334018
Shibamoto T A novel gas chromatographic method for determination of malondialdehyde from oxidized DNA. 2015 Methods Mol. Biol. pmid:25323498
Wu PS et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. 2015 PLoS ONE pmid:26087007
Amini R et al. Apigenin modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells. 2015 Hum Exp Toxicol pmid:25304968
Nakajima A et al. A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. 2015 Biosci. Biotechnol. Biochem. pmid:25266050
Farkas O et al. Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2. 2015 Oxid Med Cell Longev pmid:26180592
Chen X et al. Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. 2015 Biopharm Drug Dispos pmid:25256597
Kim M et al. Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. 2015 J. Sci. Food Agric. pmid:25199800
Fang J et al. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. 2015 Mol Med Rep pmid:26300442
Falcone Ferreyra ML et al. The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. 2015 Plant Physiol. pmid:26269546
Cattaneo L et al. Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. 2015 PLoS ONE pmid:26176704
Jeon BJ et al. Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. 2015 Eur Rev Med Pharmacol Sci pmid:26166660
Zhang Y et al. Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. 2015 Eur J Histochem pmid:26150153
Tang H et al. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. 2015 PLoS ONE pmid:26147971
Ma X et al. Acylation of Antioxidant of Bamboo Leaves with Fatty Acids by Lipase and the Acylated Derivatives' Efficiency in the Inhibition of Acrylamide Formation in Fried Potato Crisps. 2015 PLoS ONE pmid:26098744
Shiota C et al. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes. 2015 J. Nutr. Sci. Vitaminol. pmid:26052151
Dadheech N et al. Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study. 2015 PLoS ONE pmid:26047129
Zhang W et al. A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin. 2015 Molecules pmid:26042857
Lee H et al. Biosynthesis of Two Flavones, Apigenin and Genkwanin, in Escherichia coli. 2015 J. Microbiol. Biotechnol. pmid:25975614
Banerjee K and Mandal M Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. 2015 Redox Biol pmid:25965143
Zeng P et al. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. 2015 Oxid Med Cell Longev pmid:25960827
del Cerro P et al. Regulatory nodD1 and nodD2 genes of Rhizobium tropici strain CIAT 899 and their roles in the early stages of molecular signaling and host-legume nodulation. 2015 BMC Genomics pmid:25880529
Long L et al. Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. 2015 J Diabetes Res pmid:25861655
Lin H et al. A new and practical synthetic method for the synthesis of 6-O-methyl-scutellarein: one metabolite of scutellarin in vivo. 2015 Int J Mol Sci pmid:25854429
Kumar KK et al. Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats. 2015 Eur J Drug Metab Pharmacokinet pmid:24871039
Shi X et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. 2015 Int. J. Mol. Med. pmid:25394920
Chomicki G et al. The velamen protects photosynthetic orchid roots against UV-B damage, and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic. 2015 New Phytol. pmid:25345817
Avelino-Flores Mdel C et al. Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. 2015 J Med Food pmid:25299247
Aslan E and Adem S In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. 2015 J. Biochem. Mol. Toxicol. pmid:25388478
Chen RB et al. Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. 2015 PLoS ONE pmid:26656917
An F et al. Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and apigenin. 2015 Pharmazie pmid:26790189
Kim SH et al. Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. 2015 Anticancer Res. pmid:26637867
Lin CH et al. Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. 2015 Eur. J. Pharmacol. pmid:26463037
Shi ZH et al. Synthesis of scutellarein derivatives to increase biological activity and water solubility. 2015 Bioorg. Med. Chem. pmid:26455656
Yang X et al. Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase. 2015 Mol Med Rep pmid:26398147
Liu Y et al. High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite. 2015 Phytochemistry pmid:26386983
Guimarães CC et al. The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. 2015 Food Chem. Toxicol. pmid:26385725
Samet I et al. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. 2015 Differentiation pmid:26299581
Zhang L et al. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. 2015 Food Funct pmid:26292725
Li W et al. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). 2015 Biochem. Pharmacol. pmid:26291395
Lin S et al. Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. 2015 Int. J. Biol. Macromol. pmid:26275460
Farimani MM et al. Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. 2015 Planta Med. pmid:26252828
Lee W et al. Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. 2015 Can. J. Physiol. Pharmacol. pmid:26243020
Hong H et al. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. 2015 Toxicol. Sci. pmid:25349334