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Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. |
2016 |
Drug Des Devel Ther |
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Preparative Separation and Purification of the Total Flavonoids in Scorzonera austriaca with Macroporous Resins. |
2016 |
Molecules |
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Apigenin-7-O-β-D-glycoside isolation from the highly copper-tolerant plant Elsholtzia splendens. |
2016 |
J Zhejiang Univ Sci B |
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Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice. |
2016 |
Nutrients |
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New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. |
2016 |
Toxicol In Vitro |
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Apigenin Reduces Proteasome Inhibition-Induced Neuronal Apoptosis by Suppressing the Cell Death Process. |
2016 |
Neurochem. Res. |
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Protective role of apigenin in cisplatin-induced renal injury. |
2016 |
Eur. J. Pharmacol. |
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Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells. |
2016 |
Cancer Lett. |
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Physiological significance of isoprenoids and phenylpropanoids in drought response of Arundinoideae species with contrasting habitats and metabolism. |
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Plant Cell Environ. |
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Gentiana lutea exerts anti-atherosclerotic effects by preventing endothelial inflammation and smooth muscle cell migration. |
2016 |
Nutr Metab Cardiovasc Dis |
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In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii. |
2016 |
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Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice. |
2016 |
Eur. J. Pharmacol. |
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Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism In Vivo. |
2016 |
Chem Biol Drug Des |
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Involvement of Bcl-2 Signal Pathway in the Protective Effects of Apigenin on Anoxia/Reoxygenation-induced Myocardium Injury. |
2016 |
J. Cardiovasc. Pharmacol. |
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Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. |
2016 |
Phytomedicine |
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Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice. |
2015 |
Inflammation |
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Yin Q et al. |
In vitro-assessment of putative antiprogestin activities of phytochemicals and synthetic UV absorbers in human endometrial Ishikawa cells. |
2015 |
Gynecol. Endocrinol. |
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Liu X et al. |
Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway. |
2015 |
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Supuran CT |
Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation. |
2015 |
Expert Opin Ther Pat |
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Zhang T et al. |
Apigenin protects blood-brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats. |
2015 |
Int. Immunopharmacol. |
pmid:26028151
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Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin. |
2015 |
Bioorg. Med. Chem. Lett. |
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Boudjelal A et al. |
Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats. |
2015 |
Planta Med. |
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Chang CY et al. |
Apigenin, a natural flavonoid, inhibits glutamate release in the rat hippocampus. |
2015 |
Eur. J. Pharmacol. |
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Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways. |
2015 |
Mol. Cell. Biochem. |
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The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68. |
2015 |
Br. J. Nutr. |
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Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss. |
2015 |
J Colloid Interface Sci |
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Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation. |
2015 |
Microcirculation |
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Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. |
2015 |
Chem Biol Drug Des |
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Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. |
2015 |
Mol Med Rep |
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Scutellarin attenuates endothelium-dependent aasodilation impairment induced by hypoxia reoxygenation, through regulating the PKG signaling pathway in rat coronary artery. |
2015 |
Chin J Nat Med |
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Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin. |
2015 |
Biopharm Drug Dispos |
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Pharmacokinetics and tissue distribution study of Isovitexin in rats by HPLC-MS/MS. |
2015 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis. |
2015 |
Int. Immunopharmacol. |
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Mustapha N et al. |
Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. |
2015 |
Biomed. Pharmacother. |
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Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium. |
2015 |
Br. J. Nutr. |
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Costa G et al. |
Flavan hetero-dimers in the Cymbopogon citratus infusion tannin fraction and their contribution to the antioxidant activity. |
2015 |
Food Funct |
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Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. |
2015 |
Mol Nutr Food Res |
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Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. |
2015 |
Bioorg. Med. Chem. |
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Integrated pharmacokinetics and biodistribution of multiple flavonoid C-glycosides components in rat after oral administration of Abrus mollis extract and correlations with bio-effects. |
2015 |
J Ethnopharmacol |
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Eriocitrin and Apigenin as New Carbonic Anhydrase VA Inhibitors from a Virtual Screening of Calabrian Natural Products. |
2015 |
Planta Med. |
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Effect of soaking and fermentation on content of phenolic compounds of soybean (Glycine max cv. Merit) and mung beans (Vigna radiata [L] Wilczek). |
2015 |
Int J Food Sci Nutr |
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Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. |
2015 |
Arch. Pharm. Res. |
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Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements. |
2015 |
Food Chem |
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Development and validation of an HPTLC method for apigenin 7-O-glucoside in chamomile flowers and its application for fingerprint discrimination of chamomile-like materials. |
2015 |
J Pharm Biomed Anal |
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Liu W et al. |
Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells. |
2015 |
Int. J. Mol. Med. |
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Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors. |
2015 |
J Ethnopharmacol |
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Enhanced action of apigenin and naringenin combination on estrogen receptor activation in non-malignant colonocytes: implications on sorghum-derived phytoestrogens. |
2015 |
Food Funct |
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Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. |
2015 |
Int. J. Oncol. |
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Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. |
2015 |
Nat. Prod. Res. |
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Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae). |
2015 |
BMC Complement Altern Med |
pmid:25928352
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Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves. |
2015 |
J. Nat. Prod. |
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Apigenin inhibits TGF-β1-induced proliferation and migration of airway smooth muscle cells. |
2015 |
Int J Clin Exp Pathol |
pmid:26722444
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Lin CH et al. |
Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. |
2015 |
BMC Cancer |
pmid:26675309
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Hasnat MA et al. |
Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition. |
2015 |
Molecules |
pmid:26633318
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Zhu Y et al. |
Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. |
2015 |
Mol Med Rep |
pmid:25351792
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Lee JA et al. |
Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin. |
2015 |
Nutrients |
pmid:26610561
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Liu J et al. |
Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α. |
2015 |
Mol Med Rep |
pmid:25334018
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Shibamoto T |
A novel gas chromatographic method for determination of malondialdehyde from oxidized DNA. |
2015 |
Methods Mol. Biol. |
pmid:25323498
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Wu PS et al. |
Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. |
2015 |
PLoS ONE |
pmid:26087007
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Amini R et al. |
Apigenin modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells. |
2015 |
Hum Exp Toxicol |
pmid:25304968
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Nakajima A et al. |
A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. |
2015 |
Biosci. Biotechnol. Biochem. |
pmid:25266050
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Farkas O et al. |
Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2. |
2015 |
Oxid Med Cell Longev |
pmid:26180592
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Chen X et al. |
Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. |
2015 |
Biopharm Drug Dispos |
pmid:25256597
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Kim M et al. |
Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. |
2015 |
J. Sci. Food Agric. |
pmid:25199800
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Fang J et al. |
Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1. |
2015 |
Mol Med Rep |
pmid:26300442
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Falcone Ferreyra ML et al. |
The Identification of Maize and Arabidopsis Type I FLAVONE SYNTHASEs Links Flavones with Hormones and Biotic Interactions. |
2015 |
Plant Physiol. |
pmid:26269546
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Cattaneo L et al. |
Anti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells. |
2015 |
PLoS ONE |
pmid:26176704
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Apigenin inhibits indoxyl sulfate-induced endoplasmic reticulum stress and anti-proliferative pathways, CHOP and IL-6/p21, in human renal proximal tubular cells. |
2015 |
Eur Rev Med Pharmacol Sci |
pmid:26166660
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Zhang Y et al. |
Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway. |
2015 |
Eur J Histochem |
pmid:26150153
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Tang H et al. |
Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. |
2015 |
PLoS ONE |
pmid:26147971
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Ma X et al. |
Acylation of Antioxidant of Bamboo Leaves with Fatty Acids by Lipase and the Acylated Derivatives' Efficiency in the Inhibition of Acrylamide Formation in Fried Potato Crisps. |
2015 |
PLoS ONE |
pmid:26098744
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Shiota C et al. |
Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes. |
2015 |
J. Nutr. Sci. Vitaminol. |
pmid:26052151
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Dadheech N et al. |
Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study. |
2015 |
PLoS ONE |
pmid:26047129
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Zhang W et al. |
A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin. |
2015 |
Molecules |
pmid:26042857
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Lee H et al. |
Biosynthesis of Two Flavones, Apigenin and Genkwanin, in Escherichia coli. |
2015 |
J. Microbiol. Biotechnol. |
pmid:25975614
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Banerjee K and Mandal M |
Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells. |
2015 |
Redox Biol |
pmid:25965143
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Zeng P et al. |
Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. |
2015 |
Oxid Med Cell Longev |
pmid:25960827
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del Cerro P et al. |
Regulatory nodD1 and nodD2 genes of Rhizobium tropici strain CIAT 899 and their roles in the early stages of molecular signaling and host-legume nodulation. |
2015 |
BMC Genomics |
pmid:25880529
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Long L et al. |
Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat. |
2015 |
J Diabetes Res |
pmid:25861655
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Lin H et al. |
A new and practical synthetic method for the synthesis of 6-O-methyl-scutellarein: one metabolite of scutellarin in vivo. |
2015 |
Int J Mol Sci |
pmid:25854429
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Kumar KK et al. |
Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats. |
2015 |
Eur J Drug Metab Pharmacokinet |
pmid:24871039
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Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. |
2015 |
Int. J. Mol. Med. |
pmid:25394920
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Chomicki G et al. |
The velamen protects photosynthetic orchid roots against UV-B damage, and a large dated phylogeny implies multiple gains and losses of this function during the Cenozoic. |
2015 |
New Phytol. |
pmid:25345817
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Cytotoxic activity of the methanolic extract of Turnera diffusa Willd on breast cancer cells. |
2015 |
J Med Food |
pmid:25299247
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In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. |
2015 |
J. Biochem. Mol. Toxicol. |
pmid:25388478
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Chen RB et al. |
Deep Sequencing Reveals the Effect of MeJA on Scutellarin Biosynthesis in Erigeron breviscapus. |
2015 |
PLoS ONE |
pmid:26656917
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An F et al. |
Attenuation of oxidative stress of erythrocytes by the plant-derived flavonoids vitexin and apigenin. |
2015 |
Pharmazie |
pmid:26790189
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Kim SH et al. |
Suppression of AKT Potentiates Synergistic Cytotoxicity of Apigenin with TRAIL in Anaplastic Thyroid Carcinoma Cells. |
2015 |
Anticancer Res. |
pmid:26637867
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Lin CH et al. |
Thrombin-induced IL-8/CXCL8 release is mediated by CK2, MSK1, and NF-κB pathways in human lung epithelial cells. |
2015 |
Eur. J. Pharmacol. |
pmid:26463037
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Synthesis of scutellarein derivatives to increase biological activity and water solubility. |
2015 |
Bioorg. Med. Chem. |
pmid:26455656
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Apigenin attenuates myocardial ischemia/reperfusion injury via the inactivation of p38 mitogen‑activated protein kinase. |
2015 |
Mol Med Rep |
pmid:26398147
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Liu Y et al. |
High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite. |
2015 |
Phytochemistry |
pmid:26386983
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Guimarães CC et al. |
The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β25-35 peptide-induced toxicity. |
2015 |
Food Chem. Toxicol. |
pmid:26385725
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Samet I et al. |
Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. |
2015 |
Differentiation |
pmid:26299581
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Zhang L et al. |
Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. |
2015 |
Food Funct |
pmid:26292725
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Li W et al. |
Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). |
2015 |
Biochem. Pharmacol. |
pmid:26291395
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Lin S et al. |
Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. |
2015 |
Int. J. Biol. Macromol. |
pmid:26275460
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Farimani MM et al. |
Seco-ursane-type Triterpenoids from Salvia urmiensis with Apoptosis-inducing Activity. |
2015 |
Planta Med. |
pmid:26252828
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Lee W et al. |
Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. |
2015 |
Can. J. Physiol. Pharmacol. |
pmid:26243020
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Hong H et al. |
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. |
2015 |
Toxicol. Sci. |
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