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Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. |
2011 |
PLoS ONE |
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2011 |
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Polymethylated myricetin in trichomes of the wild tomato species Solanum habrochaites and characterization of trichome-specific 3'/5'- and 7/4'-myricetin O-methyltransferases. |
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Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. |
2011 |
Phytochemistry |
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Two new flavone C-glycosides from Trollius ledebourii. |
2011 |
Chem. Pharm. Bull. |
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Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. |
2011 |
J. Microbiol. Biotechnol. |
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The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. |
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Microbiology (Reading, Engl.) |
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Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. |
2011 |
BMC Genomics |
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De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. |
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BMC Genomics |
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MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. |
2011 |
Plant Cell |
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In vitro analysis of iron chelating activity of flavonoids. |
2011 |
J. Inorg. Biochem. |
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Acta Crystallogr Sect E Struct Rep Online |
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Antiviral activity of four types of bioflavonoid against dengue virus type-2. |
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Virol. J. |
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Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. |
2011 |
Nature |
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Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). |
2011 |
Pharmacognosy Res |
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Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea). |
2011 |
Front Pharmacol |
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Senescence (ageing) @ 2011. |
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Indian J Dermatol |
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Toxicological aspects of the use of phenolic compounds in disease prevention. |
2011 |
Interdiscip Toxicol |
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Sulfated-polysaccharide fraction from red algae Gracilaria caudata protects mice gut against ethanol-induced damage. |
2011 |
Mar Drugs |
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. |
2011 |
Int J Mol Sci |
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A review on recent advances in dry eye: Pathogenesis and management. |
2011 |
Oman J Ophthalmol |
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Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. |
2011 |
Evid Based Complement Alternat Med |
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Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. |
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J. Korean Med. Sci. |
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Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. |
2011 |
Eur J Med Chem |
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Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. |
2011 |
Drug Des Devel Ther |
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Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. |
2011 |
PLoS ONE |
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Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis. |
2011 |
Funct. Integr. Genomics |
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Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. |
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PLoS ONE |
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Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. |
2011 |
PLoS ONE |
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Chrysosplenol C increases contraction in rat ventricular myocytes. |
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J. Cardiovasc. Pharmacol. |
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Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. |
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Nutr Res Pract |
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2011 |
Plant Cell |
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Anti-cancer natural products isolated from chinese medicinal herbs. |
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Chin Med |
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Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). |
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Acta Crystallogr Sect E Struct Rep Online |
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Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). |
2011 |
J Chromatogr A |
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Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. |
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J. Biol. Chem. |
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Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. |
2011 |
J Neuroinflammation |
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SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. |
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Int J Mol Imaging |
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Novel flavonoids with antiproliferative activities against breast cancer cells. |
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J. Med. Chem. |
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3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. |
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Acta Crystallogr Sect E Struct Rep Online |
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Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. |
2011 |
PLoS ONE |
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Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. |
2011 |
Pharmacogn Mag |
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Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. |
2011 |
Drug Metab Lett |
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Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. |
2011 |
Malar. J. |
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Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. |
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J. Alzheimers Dis. |
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Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. |
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Plant Physiol. |
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Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. |
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J. Pharmacol. Exp. Ther. |
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Neuro-inflammation, blood-brain barrier, seizures and autism. |
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J Neuroinflammation |
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Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
2011 |
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Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. |
2011 |
Bioorg. Med. Chem. |
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Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. |
2011 |
Phytomedicine |
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In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. |
2011 |
J. Antimicrob. Chemother. |
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Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. |
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J. Korean Med. Sci. |
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Effects of flavone 6-substitutions on GABAA receptors efficacy. |
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Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. |
2011 |
Evid Based Complement Alternat Med |
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Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. |
2011 |
Phytochemistry |
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Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. |
2011 |
Evid Based Complement Alternat Med |
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Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. |
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Total flavonoids extracted from xiaobuxin-tang on the hyperactivity of hypothalamic-pituitary-adrenal axis in chronically stressed rats. |
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Evid Based Complement Alternat Med |
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Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. |
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The genetic architecture of branched-chain amino acid accumulation in tomato fruits. |
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Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. |
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Cancer Chemother. Pharmacol. |
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Andrographolide: a new plant-derived antineoplastic entity on horizon. |
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Evid Based Complement Alternat Med |
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In vitro evaluation of flavonoids from Eriodictyon californicum for antagonist activity against the bitterness receptor hTAS2R31. |
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J. Agric. Food Chem. |
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A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. |
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Mol. Pharmacol. |
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Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. |
2011 |
J Ethnopharmacol |
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Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. |
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Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. |
2011 |
Mol. Pharmacol. |
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Pd-carbene catalyzed carbonylation reactions of aryl iodides. |
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Dalton Trans |
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Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. |
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Cancer Invest. |
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Two new special flavones from Uvaria accuminata. |
2011 |
Nat. Prod. Res. |
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Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. |
2011 |
Int. J. Biol. Macromol. |
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Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. |
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Appl. Microbiol. Biotechnol. |
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Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. |
2011 |
Anticancer Res. |
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Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer. |
2011 |
Clin Lung Cancer |
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Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. |
2011 |
J Chromatogr A |
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Time-dependent approaches for the calculation of intersystem crossing rates. |
2011 |
J Chem Phys |
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Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. |
2011 |
Bioorg. Med. Chem. Lett. |
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Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. |
2011 |
Cell Death Dis |
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Flavans from the leaf of Ilex centrochinensis. |
2011 |
J Asian Nat Prod Res |
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Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. |
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J. Agric. Food Chem. |
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Non-covalent inhibitors of rhinovirus 3C protease. |
2011 |
Bioorg. Med. Chem. Lett. |
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Extracting natural dyes from wool--an evaluation of extraction methods. |
2011 |
Anal Bioanal Chem |
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Structural elucidation of a new flavone from Sarcopyramis nepalensis. |
2011 |
J Asian Nat Prod Res |
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A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. |
2011 |
PLoS ONE |
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A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. |
2011 |
PLoS ONE |
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Evaluation of quality control strategies in Scutellaria herbal medicines. |
2011 |
J Pharm Biomed Anal |
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Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. |
2011 |
Planta Med. |
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Antihypertensive effect of total flavone extracts from Puerariae Radix. |
2011 |
J Ethnopharmacol |
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New perspectives on chinese herbal medicine (zhong-yao) research and development. |
2011 |
Evid Based Complement Alternat Med |
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Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. |
2011 |
Regul. Toxicol. Pharmacol. |
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Flavonoids: A versatile source of anticancer drugs. |
2011 |
Pharmacogn Rev |
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Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. |
2011 |
Neoplasma |
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Clark ST and Verwoerd WS |
A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. |
2011 |
BMC Bioinformatics |
pmid:21849042
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Cai WJ et al. |
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
2011 |
PLoS ONE |
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Ohno S et al. |
A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). |
2011 |
J. Exp. Bot. |
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Samarghandian S et al. |
Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. |
2011 |
Clinics (Sao Paulo) |
pmid:21808878
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Xiao J et al. |
Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. |
2011 |
Integr Biol (Camb) |
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