| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fong YK et al. | In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. | 2012 | J Ethnopharmacol | pmid:21906668 |
| Chen WQ et al. | A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22901896 |
| Tsai IT et al. | Flavone is efficient to protect zebrafish fins from UV-induced damage. | 2012 | Drug Chem Toxicol | pmid:22289409 |
| Wei Z et al. | Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. | 2012 | J. Biochem. Mol. Toxicol. | pmid:22696397 |
| Chen CC et al. | Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. | 2012 | PLoS ONE | pmid:22272328 |
| Shih HC and Yang LL | Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle. | 2012 | Pharm Biol | pmid:22471999 |
| Adejumo OE et al. | Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells. | 2012 | J Pharm Bioallied Sci | pmid:22557922 |
| Guo AJ et al. | Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. | 2012 | Chin Med | pmid:22546174 |
| Asadi S and Theoharides TC | Corticotropin-releasing hormone and extracellular mitochondria augment IgE-stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin. | 2012 | J Neuroinflammation | pmid:22559745 |
| Chen HJ et al. | Determination of phenolic acids and flavonoids in Taraxacum formosanum Kitam by liquid chromatography-tandem mass spectrometry coupled with a post-column derivatization technique. | 2012 | Int J Mol Sci | pmid:22312251 |
| Wink M et al. | Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. | 2012 | Front Microbiol | pmid:22536197 |
| Peterson JJ et al. | Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations. | 2012 | Nutr. Rev. | pmid:22946850 |
| Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
| Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
| Shih TL et al. | An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. | 2012 | Molecules | pmid:22777189 |
| Thomas CM et al. | Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. | 2012 | PLoS ONE | pmid:22768128 |
| Welch A et al. | Habitual flavonoid intakes are positively associated with bone mineral density in women. | 2012 | J. Bone Miner. Res. | pmid:22549983 |
| Joshi SC and Mathela CS | Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. | 2012 | Pharmacognosy Res | pmid:22518079 |
| Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
| Clark BR et al. | Flavone C-glycosides from Anthurium andraeanum. | 2012 | Nat Prod Commun | pmid:22816298 |
| Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
| Niraula NP et al. | Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. | 2012 | J. Microbiol. Biotechnol. | pmid:22713981 |
| Chen LY et al. | Structural elucidation and bioactivity of biflavonoids from the stems of Wikstroemia taiwanensis. | 2012 | Int J Mol Sci | pmid:22312302 |
| Watts SD et al. | A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. | 2012 | PLoS ONE | pmid:22506078 |
| Li Y et al. | [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792791 |
| Vermelho AB et al. | Microbial enzyme: applications in industry and in bioremediation. | 2012 | Enzyme Res | pmid:22496966 |
| Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
| Walch SG et al. | Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. | 2012 | Anal Chem Insights | pmid:22493561 |
| Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
| Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
| Li H et al. | De novo transcriptome of safflower and the identification of putative genes for oleosin and the biosynthesis of flavonoids. | 2012 | PLoS ONE | pmid:22363528 |
| Hostetler G et al. | Flavone deglycosylation increases their anti-inflammatory activity and absorption. | 2012 | Mol Nutr Food Res | pmid:22351119 |
| Zhang H and Zhang C | Vasoprotection by dietary supplements and exercise: role of TNFα signaling. | 2012 | Exp Diabetes Res | pmid:22110483 |
| Shi L et al. | Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. | 2012 | Cell. Mol. Neurobiol. | pmid:21984341 |
| Yang WS et al. | Nanostructured, self-assembling peptide K5 blocks TNF-α and PGE₂ production by suppression of the AP-1/p38 pathway. | 2012 | Mediators Inflamm. | pmid:22315508 |
| Murata T et al. | Hyaluronidase inhibitors from Keiskea japonica. | 2012 | Chem. Pharm. Bull. | pmid:22223383 |
| Toton E et al. | The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. | 2012 | Eur. J. Pharmacol. | pmid:22381066 |
| Fasinu PS et al. | An overview of the evidence and mechanisms of herb-drug interactions. | 2012 | Front Pharmacol | pmid:22557968 |
| Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
| Wang D et al. | Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. | 2012 | Oxid Med Cell Longev | pmid:22496932 |
| Engelbertz J et al. | Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. | 2012 | J Ethnopharmacol | pmid:22465593 |
| Narwal M et al. | Homogeneous screening assay for human tankyrase. | 2012 | J Biomol Screen | pmid:22357873 |
| Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
| Cai M et al. | The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. | 2012 | Eur. J. Pharmacol. | pmid:22683875 |
| Wang Y et al. | Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. | 2012 | Planta Med. | pmid:21870321 |
| Sharma M et al. | Expression of flavonoid 3'-hydroxylase is controlled by P1, the regulator of 3-deoxyflavonoid biosynthesis in maize. | 2012 | BMC Plant Biol. | pmid:23113982 |
| Hammoud L et al. | A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. | 2012 | Nat. Prod. Res. | pmid:21815723 |
| Brito I et al. | 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22259537 |
| Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
| Seki N et al. | Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways. | 2012 | J. Cell. Biochem. | pmid:22359269 |
| Jansakul C et al. | Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. | 2012 | Eur. J. Pharmacol. | pmid:22800934 |
| Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
| Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| Mijangos MV et al. | Microwave-assisted C-3 selective oxidative radical alkylation of flavones. | 2012 | Org. Biomol. Chem. | pmid:22395456 |
| Surichan S et al. | Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. | 2012 | Food Chem. Toxicol. | pmid:22743247 |
| Guo F et al. | Effect of the citrus lycopene β-cyclase transgene on carotenoid metabolism in transgenic tomato fruits. | 2012 | PLoS ONE | pmid:22384184 |
| Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
| Kim YW et al. | DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793913 |
| Gates PJ and Lopes NP | Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry. | 2012 | Int J Anal Chem | pmid:22505914 |
| Patel CA et al. | Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn). | 2012 | ISRN Pharmacol | pmid:22530142 |
| Lin TY et al. | Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22759588 |
| Pohanka M | Antioxidants countermeasures against sulfur mustard. | 2012 | Mini Rev Med Chem | pmid:22512566 |
| Xiao L et al. | Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens. | 2012 | PLoS ONE | pmid:22545152 |
| Begum N et al. | Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. | 2012 | Mutat. Res. | pmid:22516036 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| Hunyadi A et al. | Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. | 2011 | PLoS ONE | pmid:21912610 |
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Kloska A et al. | Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. | 2011 | Metab Brain Dis | pmid:21305347 |
| Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
| Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
| Liu LZ et al. | Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21893035 |
| Singh S et al. | 2-(4-Chloro-phen-yl)chromen-4-one. | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:22199687 |
| Zandi K et al. | Antiviral activity of four types of bioflavonoid against dengue virus type-2. | 2011 | Virol. J. | pmid:22201648 |
| Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
| Bhavsar AS et al. | A review on recent advances in dry eye: Pathogenesis and management. | 2011 | Oman J Ophthalmol | pmid:21897618 |
| Manna P et al. | Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. | 2011 | Evid Based Complement Alternat Med | pmid:21869899 |
| Lee KN et al. | Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. | 2011 | J. Korean Med. Sci. | pmid:21860559 |
| Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
| Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
| Nerurkar PV et al. | Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. | 2011 | J Neuroinflammation | pmid:21639917 |
| Perry CN et al. | Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. | 2011 | PLoS ONE | pmid:21339825 |
| Marinova MD and Tchorbanov BP | Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. | 2011 | Enzyme Res | pmid:21318132 |
| Garateix A et al. | Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. | 2011 | Mol Pain | pmid:21261973 |
| Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
| Flemmig J et al. | Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. | 2011 | Phytomedicine | pmid:21144719 |
| Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
| Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
| Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
| Uchi H et al. | A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. | 2011 | Evid Based Complement Alternat Med | pmid:19996156 |
| Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
| Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
| Bensasson RV et al. | Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. | 2011 | Free Radic. Biol. Med. | pmid:21745563 |
| Cai WJ et al. | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. | 2011 | PLoS ONE | pmid:22216122 |