FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Encephalitis D004660 15 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Adenoma D000236 40 associated lipids
Leukemia P388 D007941 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Cabrera M et al. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. 2010 Bioorg. Med. Chem. pmid:20639112
Chen IL et al. Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. 2008 Bioorg. Med. Chem. pmid:18662883
Lin YM et al. Chalcones and flavonoids as anti-tuberculosis agents. 2002 Bioorg. Med. Chem. pmid:12057669
Betti L et al. Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion. 2004 Bioorg. Med. Chem. pmid:15018926
Wang TC et al. Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives. 2005 Bioorg. Med. Chem. pmid:15990314
Boumendjel A et al. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. 2007 Bioorg. Med. Chem. pmid:17317193
Ono M et al. Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. 2007 Bioorg. Med. Chem. pmid:17035032
Lameira J et al. Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: a density functional theory study. 2006 Bioorg. Med. Chem. pmid:16890444
Kubo I et al. Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. 2000 Bioorg. Med. Chem. pmid:10976523
Xiang H et al. Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. 2010 Bioorg. Med. Chem. pmid:20392645
Dong X et al. Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. 2008 Bioorg. Med. Chem. pmid:18678502
Greeff J et al. Antioxidant properties of 4-quinolones and structurally related flavones. 2012 Bioorg. Med. Chem. pmid:22197671
Iori F et al. Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. 2005 Bioorg. Med. Chem. pmid:15914008
Malolanarasimhan K et al. Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe. 2005 Bioorg. Med. Chem. pmid:15781383
Amato E et al. Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. 2014 Bioorg. Med. Chem. pmid:24345481
Valenti P et al. Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid. 2000 Bioorg. Med. Chem. pmid:10968283
Mavel S et al. Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1). 2006 Bioorg. Med. Chem. pmid:16263302
Pick A et al. Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). 2011 Bioorg. Med. Chem. pmid:21354800
Nilsson J et al. Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors. 2008 Bioorg. Med. Chem. Lett. pmid:18851913
Balboni G et al. Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. 2012 Bioorg. Med. Chem. Lett. pmid:22487176