FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Encephalitis D004660 15 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Adenoma D000236 40 associated lipids
Leukemia P388 D007941 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Xu H et al. Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. 2010 Bioresour. Technol. pmid:20708926
Kim JH et al. Characterization of flavonoid 7-O-glucosyltransferase from Arabidopsis thaliana. 2006 Biosci. Biotechnol. Biochem. pmid:16794327
Kanho H et al. Glucosylation of phenolic compounds by Pharbitis nil hairy roots: I. Glucosylation of coumarin and flavone derivatives. 2004 Biosci. Biotechnol. Biochem. pmid:15502347
Ueda H et al. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. 2004 Biosci. Biotechnol. Biochem. pmid:14745173
Han DH et al. Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. 2002 Biosci. Biotechnol. Biochem. pmid:12224631
Matsui T et al. Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. 2002 Biosci. Biotechnol. Biochem. pmid:12005074
Gao H et al. Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. 2004 Biosci. Biotechnol. Biochem. pmid:14981300
Yun CS et al. Expression of parsley flavone synthase I establishes the flavone biosynthetic pathway in Arabidopsis thaliana. 2008 Biosci. Biotechnol. Biochem. pmid:18391443
Feng XT et al. Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. 2014 Biosci. Biotechnol. Biochem. pmid:25273139
Watanabe J et al. Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. 2005 Biosci. Biotechnol. Biochem. pmid:15665459
Cao H et al. Microbial biotransformation of bioactive flavonoids. Biotechnol. Adv. pmid:25447420
Takahashi-Ando N et al. A screening system for inhibitors of trichothecene biosynthesis: hydroxylation of trichodiene as a target. 2008 Biotechnol. Lett. pmid:18239857
Wilczańska-Barska A et al. Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. 2012 Biotechnol. Lett. pmid:22639092
Park NI et al. Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. 2012 Biotechnol. Lett. pmid:22113884
Kunnumakkara AB et al. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. 2007 Blood pmid:17332240
Lee YJ et al. Characterization of flavone synthase I from rice. 2008 BMB Rep pmid:18304453
Bradshaw PC and Pfeiffer DR Loss of NAD(H) from swollen yeast mitochondria. 2006 BMC Biochem. pmid:16433924
Clark ST and Verwoerd WS A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. 2011 BMC Bioinformatics pmid:21849042
Zuk M et al. Flavonoid engineering of flax potentiate its biotechnological application. 2011 BMC Biotechnol. pmid:21276227
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309