FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Encephalitis D004660 15 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Adenoma D000236 40 associated lipids
Leukemia P388 D007941 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Lee JM et al. Acute Toxicity and General Pharmacological Action of QGC EXT. 2012 Korean J. Physiol. Pharmacol. pmid:22416220
Galindo P et al. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. 2012 PLoS ONE pmid:22427863
Bairwa R et al. Trachyspermum ammi. 2012 Pharmacogn Rev pmid:22654405
Huang Y et al. Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin. 2012 J. Exp. Clin. Cancer Res. pmid:22607709
Zamboni A et al. Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. 2012 BMC Genomics pmid:22433273
Hamilton ML et al. Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. 2012 Phytochemistry pmid:22959223
Klier L et al. Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. 2012 J. Am. Chem. Soc. pmid:22860983
Zbidah M et al. Apigenin-induced suicidal erythrocyte death. 2012 J. Agric. Food Chem. pmid:22132906
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Palmieri D et al. Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. 2012 Mol. Cell. Biochem. pmid:22899172
El-Alfy TS et al. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. 2011 Oct-Dec Sci Pharm pmid:22145118
Zhao E and Mu Q Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. 2011 Jan-Mar Sci Pharm pmid:21617769
Son MJ et al. Chrysosplenol C increases contraction in rat ventricular myocytes. 2011 J. Cardiovasc. Pharmacol. pmid:21052017
Wera M et al. 3-Hy-droxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21523104
Zolkipli Z et al. Vulnerability to oxidative stress in vitro in pathophysiology of mitochondrial short-chain acyl-CoA dehydrogenase deficiency: response to antioxidants. 2011 PLoS ONE pmid:21483766
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Zhou T et al. Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants. 2011 J Chromatogr A pmid:21531418
Mehla R et al. A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. 2011 PLoS ONE pmid:22140483
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Samarghandian S et al. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. 2011 Clinics (Sao Paulo) pmid:21808878