FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Encephalitis D004660 15 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Cystitis D003556 23 associated lipids
Adenoma D000236 40 associated lipids
Leukemia P388 D007941 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Tremblay AM and Giguère V The NR3B subgroup: an ovERRview. 2007 Nucl Recept Signal pmid:18174917
Rahigude A et al. Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. 2012 Neuroscience pmid:22999973
Cheng XP et al. Inhibitory effect of total flavone of Abelmoschus manihot L. Medic on NMDA receptor-mediated current in cultured rat hippocampal neurons. 2006 Neurosci. Res. pmid:16616791
Chen HQ et al. Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. 2008 Neurosci. Lett. pmid:18952146
Kang KP et al. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. 2011 Nephrol. Dial. Transplant. pmid:20817674
Kozics K et al. Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. 2011 Neoplasma pmid:21895405
Kragh M et al. Acute effects of vascular modifying agents in solid tumors assessed by noninvasive laser Doppler flowmetry and near infrared spectroscopy. 2002 May-Jun Neoplasia pmid:11988846
Zhang H et al. Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24043291
Nagib DA and MacMillan DW Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. 2011 Nature pmid:22158245
Shiono M et al. Phytochemistry: structure of the blue cornflower pigment. 2005 Nature pmid:16094358
Liu S et al. Anticancer activity and quantitative analysis of flavone of Cirsium japonicum DC. 2007 Nat. Prod. Res. pmid:17680503
Li LZ et al. Flavonoids and other constituents from Aletris spicata and their chemotaxonomic significance. 2014 Nat. Prod. Res. pmid:24896299
D'Abrosca B et al. A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. 2013 Nat. Prod. Res. pmid:22708583
Hammoud L et al. A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. 2012 Nat. Prod. Res. pmid:21815723
Likhitwitayawuid K et al. Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha. 2005 Nat. Prod. Res. pmid:15715263
Said SA Two new special flavones from Uvaria accuminata. 2011 Nat. Prod. Res. pmid:21644179
Wang MH et al. A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi. 2014 Nat. Prod. Res. pmid:24995563
Wang KW et al. A new lignan with anti-tumour activity from Polygonum perfoliatum L. 2013 Nat. Prod. Res. pmid:22533633
Herath W et al. Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone. 2009 Nat. Prod. Res. pmid:19731142
Fang W et al. Flavonoids from the aerial parts of Macrothelypteris torresiana. 2011 Nat. Prod. Res. pmid:21240759