FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Lymphedema D008209 4 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Encephalitis D004660 15 associated lipids
Cystitis D003556 23 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Adenoma D000236 40 associated lipids
Leukemia P388 D007941 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Weight Loss D015431 56 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Melanoma D008545 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Park SR et al. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. 2011 J. Microbiol. Biotechnol. pmid:22127124
Luo H et al. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. 2011 BMC Genomics pmid:22369100
Zhao J et al. MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. 2011 Plant Cell pmid:21467581
Mladěnka P et al. In vitro analysis of iron chelating activity of flavonoids. 2011 J. Inorg. Biochem. pmid:21450273
Lima de Medeiros BJ et al. Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). 2011 Pharmacognosy Res pmid:21772750
Neves MP et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. 2011 Eur J Med Chem pmid:21496973
Yang C et al. Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. 2011 PLoS ONE pmid:21779360
Han S et al. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. 2011 Nutr Res Pract pmid:21779522
Tan W et al. Anti-cancer natural products isolated from chinese medicinal herbs. 2011 Chin Med pmid:21777476
Villela A et al. Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). 2011 J Chromatogr A pmid:21999916
Zhang J et al. Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. 2011 Pharmacogn Mag pmid:21472077
Pham MH et al. Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. 2011 Drug Metab Lett pmid:21457135
Rasoanaivo P et al. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. 2011 Malar. J. pmid:21411015
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Novy P et al. In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. 2011 J. Antimicrob. Chemother. pmid:21421582
Seo YJ et al. Apoptotic effects of genistein, biochanin-A and apigenin on LNCaP and PC-3 cells by p21 through transcriptional inhibition of polo-like kinase-1. 2011 J. Korean Med. Sci. pmid:22065906
Ren L et al. Effects of flavone 6-substitutions on GABAA receptors efficacy. 2011 Eur. J. Pharmacol. pmid:21914441
Tayarani-Najaran Z et al. Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. 2011 Evid Based Complement Alternat Med pmid:20028719
Shin SY et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. 2011 Bioorg. Med. Chem. Lett. pmid:21907578
Kochevenko A and Fernie AR The genetic architecture of branched-chain amino acid accumulation in tomato fruits. 2011 J. Exp. Bot. pmid:21436187
Phromnoi K et al. A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents. 2011 Mol. Pharmacol. pmid:20930110
Ortet R et al. Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. 2011 J Ethnopharmacol pmid:21982788
Yamagata K et al. Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells. 2011 Microvasc. Res. pmid:21040737
Polier G et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. 2011 Cell Death Dis pmid:21776020
Li LJ et al. Flavans from the leaf of Ilex centrochinensis. 2011 J Asian Nat Prod Res pmid:21462042
Kim JY et al. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. 2011 J. Agric. Food Chem. pmid:21434689
Cai RL et al. Antihypertensive effect of total flavone extracts from Puerariae Radix. 2011 J Ethnopharmacol pmid:20933075
Wang YJ et al. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. 2011 Regul. Toxicol. Pharmacol. pmid:20920542
Chahar MK et al. Flavonoids: A versatile source of anticancer drugs. 2011 Pharmacogn Rev pmid:22096313
Xiao J et al. Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. 2011 Integr Biol (Camb) pmid:21947088
Mafuvadze B et al. Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells. 2010 Sep-Oct Menopause pmid:20551847
Marczak Ł et al. Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. 2010 May-Jun Phytochem Anal pmid:19950391
Acharya A et al. Redox regulation in cancer: a double-edged sword with therapeutic potential. 2010 Jan-Feb Oxid Med Cell Longev pmid:20716925
Carneiro CD et al. Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen. 2010 Aug-Sep Food Chem. Toxicol. pmid:20561949
Kurian GA and Paddikkala J Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury. 2010 Indian J Pharm Sci pmid:21969747
Seo J et al. Time-dependent density functional theory-assisted absolute configuration determination of cis-dihydrodiol metabolite produced from isoflavone by biphenyl dioxygenase. 2010 Anal. Biochem. pmid:19854147
Rayyan S et al. Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L. 2010 J. Agric. Food Chem. pmid:20486688
Yamada K et al. A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. 2010 Phytochemistry pmid:20832830
Han Y et al. Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. 2010 Plant Physiol. pmid:20357139
Meydani M and Hasan ST Dietary polyphenols and obesity. 2010 Nutrients pmid:22254051
Torres-Piedra M et al. A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. 2010 Eur J Med Chem pmid:20346546
Morant M et al. Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. 2010 Mol Plant pmid:20008451
Halbwirth H The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. 2010 Int J Mol Sci pmid:20386656
Neveu V et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. 2010 Database (Oxford) pmid:20428313
Xia EQ et al. Biological activities of polyphenols from grapes. 2010 Int J Mol Sci pmid:20386657
Chirumbolo S The role of quercetin, flavonols and flavones in modulating inflammatory cell function. 2010 Inflamm Allergy Drug Targets pmid:20887269
Ghasemzadeh A et al. Effect of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). 2010 Int J Mol Sci pmid:21152306
Medjakovic S et al. Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. 2010 Nutrients pmid:22254019
Xiang H et al. Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities. 2010 Bioorg. Med. Chem. pmid:20392645
Wang P et al. Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. 2010 PLoS ONE pmid:20808785
Liao Z et al. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. 2010 Arch. Pharm. Res. pmid:20361298
Ono E et al. Co-pigmentation and flavonoid glycosyltransferases in blue Veronica persica flowers. 2010 Phytochemistry pmid:20223486
Villaflores OB et al. Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. 2010 Pharmacogn Mag pmid:21120040
Prajapati RP et al. Phytochemical and pharmacological review of Lagenaria sicereria. 2010 J Ayurveda Integr Med pmid:21731373
Kim MJ et al. TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. 2010 Biochem. Pharmacol. pmid:20804741
Vidyalakshmi K et al. Antinociceptive effect of certain dihydroxy flavones in mice. 2010 Pharmacol. Biochem. Behav. pmid:20346369
Joe EJ et al. Engineering of flavonoid O-methyltransferase for a novel regioselectivity. 2010 Mol. Cells pmid:20680484
Sharma RD et al. Possible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against Brugia malayi microfilariae. 2010 Pharmacognosy Res pmid:21713137
Pichichero E et al. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. 2010 Int. J. Oncol. pmid:20811719
Shukla S and Gupta S Apigenin: a promising molecule for cancer prevention. 2010 Pharm. Res. pmid:20306120
Zhou JM et al. Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis. 2010 BMC Plant Biol. pmid:20670441
Kurian G et al. A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. 2010 J Young Pharm pmid:21264119
Ghasemzadeh A et al. Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. 2010 Int J Mol Sci pmid:21151455
Luo H et al. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. 2010 BMC Plant Biol. pmid:20854695
Zou GA et al. Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. 2010 Molecules pmid:20335965
Chen EP et al. A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. 2010 Drug Metab. Dispos. pmid:20843940
Ragab FA et al. Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. 2010 Chem. Pharm. Bull. pmid:20823592
Stark JL et al. Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. 2010 Proteins pmid:20818668
Chung KS et al. Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. 2010 Mol Nutr Food Res pmid:20397191
Schubert M et al. Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. 2010 Planta pmid:19915863
Goodger JQ et al. Isolation of intact sub-dermal secretory cavities from Eucalyptus. 2010 Plant Methods pmid:20807444
Zhang A et al. Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. 2010 J Ovarian Res pmid:20723224
Du Y et al. CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. 2010 Plant Physiol. pmid:20647377
Du Y et al. Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. 2010 J. Exp. Bot. pmid:20007684
Filak LK et al. Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. 2010 J. Biol. Inorg. Chem. pmid:20369265
Lei W et al. Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. 2010 Genet. Mol. Biol. pmid:21637484
Parravicini C et al. Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. 2010 BMC Struct. Biol. pmid:20233425
Zhang A et al. Anti-HER-2 engineering antibody ChA21 inhibits growth and induces apoptosis of SK-OV-3 cells. 2010 J. Exp. Clin. Cancer Res. pmid:20214830
Akhtar TA et al. Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. 2010 Plant Cell Environ. pmid:20199616
Perez-Vizcaino F and Duarte J Flavonols and cardiovascular disease. 2010 Mol. Aspects Med. pmid:20837053
Yang JM et al. Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. 2010 J. Agric. Food Chem. pmid:20734985
Büchner FL et al. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). 2010 Cancer Causes Control pmid:19924549
Song WY et al. Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet. 2010 Nutr Res Pract pmid:20198203
Mays JR et al. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. 2010 Bioorg. Med. Chem. pmid:19932969
Lewin G et al. Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. 2010 J. Nat. Prod. pmid:20356063
Mitra I et al. Chemometric modeling of free radical scavenging activity of flavone derivatives. 2010 Eur J Med Chem pmid:20800321
Xiao J et al. Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. 2010 Mol Nutr Food Res pmid:20306480
Zeng YW et al. [The zonal characteristics and cultivated types difference of functional components in brown rice for core collection of Yunnan rice]. 2010 Guang Pu Xue Yu Guang Pu Fen Xi pmid:21322246
Wang J et al. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. 2010 PLoS ONE pmid:20221395
Zhang C et al. Functional characterization of cis-acting elements mediating flavone-inducible expression of CYP321A1. 2010 Insect Biochem. Mol. Biol. pmid:20854909
Zhang Y et al. Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. 2010 Nutr Res pmid:20851305
Nessa F et al. Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera. 2010 Pharm Biol pmid:20738223
Knjazeva T and Kaljurand M Capillary electrophoresis frontal analysis for the study of flavonoid interactions with human serum albumin. 2010 Anal Bioanal Chem pmid:20422159
Guendel I et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. 2010 AIDS Res Ther pmid:20334651
Valant-Vetschera KM et al. Chemodiversity of exudate flavonoids in Dionysia (Primulaceae): a comparative study. 2010 Phytochemistry pmid:20378133
Chen Q et al. Measurement of total flavone content in snow lotus (Saussurea involucrate) using near infrared spectroscopy combined with interval PLS and genetic algorithm. 2010 Spectrochim Acta A Mol Biomol Spectrosc pmid:20338806
Yashiroda Y et al. A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. 2010 Biochem. Biophys. Res. Commun. pmid:20214890
Bacher M et al. Complete 1H and 13C NMR data assignment of new constituents from Severinia buxifolia. 2010 Magn Reson Chem pmid:19937908
Kasai N et al. Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. 2010 J. Biochem. pmid:19819902
Rajesh G et al. Effect of hydroxyl substitution of flavone on angiogenesis and free radical scavenging activities: a structure-activity relationship studies using computational tools. 2010 Eur J Pharm Sci pmid:19874890