| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphedema | D008209 | 4 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
| Liu LZ et al. | Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21893035 |
| Nagai T et al. | Inhibition of mouse liver sialidase by plant flavonoids. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775264 |
| Fukuda I et al. | Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17560542 |
| Yashiroda Y et al. | A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20214890 |
| Arakaki N et al. | Induction of G1 cell cycle arrest in human umbilical vein endothelial cells by flavone's inhibition of the extracellular signal regulated kinase cascade. | 2004 | Biochem. Cell Biol. | pmid:15499387 |
| KOEPPEN BH et al. | The flavone C-glycosides and flavonol O-glycosides of Aspalathus acuminatus (rooibos tea). | 1962 | Biochem. J. | pmid:14457727 |
| MARSH CA | Glucuronide metabolism in plants. II. The isolation of flavone glucosiduronic acids from plants. | 1955 | Biochem. J. | pmid:14351142 |
| Wiejak J et al. | Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | 2013 | Biochem. J. | pmid:23782265 |
| Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |
| Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
| Bandyopadhyay S et al. | Attenuation of osteoclastogenesis and osteoclast function by apigenin. | 2006 | Biochem. Pharmacol. | pmid:16750176 |
| Lin HY et al. | Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. | 2003 | Biochem. Pharmacol. | pmid:14563492 |
| Verbeek R et al. | The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells. | 2004 | Biochem. Pharmacol. | pmid:15276069 |
| Huen MS et al. | Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands. | 2003 | Biochem. Pharmacol. | pmid:14637197 |
| Kim MJ et al. | TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells. | 2010 | Biochem. Pharmacol. | pmid:20804741 |
| Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
| Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
| Kundu R et al. | Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. | 2011 | Biochem. Pharmacol. | pmid:21801714 |
| Vargo MA et al. | Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. | 2006 | Biochem. Pharmacol. | pmid:16844095 |