FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Stomach Ulcer D013276 75 associated lipids
Hyperlipidemias D006949 73 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 | Total 32

PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Hamman C et al. The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules. 2011 J Chromatogr A pmid:21939976
Kloska A et al. Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. 2011 Metab Brain Dis pmid:21305347
Bojić M et al. Evaluation of antiaggregatory activity of flavonoid aglycone series. 2011 Nutr J pmid:21745360
Shiromwar SS and Chidrawar VR Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. 2011 Pharmacognosy Res pmid:22022172
Zuk M et al. Flavonoid engineering of flax potentiate its biotechnological application. 2011 BMC Biotechnol. pmid:21276227
Lee SJ et al. Hypolipidemic and hypoglycemic effects of Orostachys japonicus A. Berger extracts in streptozotocin-induced diabetic rats. 2011 Nutr Res Pract pmid:21994524
Xiao J et al. Noncovalent interaction of dietary polyphenols with common human plasma proteins. 2011 J. Agric. Food Chem. pmid:21863815
Thirupathy KP et al. Neuropharmacological activity of Lippia nodiflora Linn. 2011 Pharmacognosy Res pmid:22022169
Elmann A et al. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima. 2011 BMC Complement Altern Med pmid:22018032
Gohain M et al. Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21753961
Marinova MD and Tchorbanov BP Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes. 2011 Enzyme Res pmid:21318132
Gauci AJ et al. Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. 2011 J. Alzheimers Dis. pmid:21891862
Hämäläinen M et al. Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. 2011 Planta Med. pmid:21341175
Gao L et al. 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. 2011 Bioorg. Med. Chem. Lett. pmid:21843936
Baxter A et al. Non-covalent inhibitors of rhinovirus 3C protease. 2011 Bioorg. Med. Chem. Lett. pmid:21183345
Uchi H et al. A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. 2011 Evid Based Complement Alternat Med pmid:19996156
Semwal RB et al. Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. 2011 J Ethnopharmacol pmid:21354288
Khan MS et al. Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. 2011 Chem. Biol. Interact. pmid:21554863
Wang XX et al. Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. 2011 Int J Mol Sci pmid:21731458
Maher P et al. Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. 2011 PLoS ONE pmid:21738623
Zhao E and Mu Q Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. 2011 Jan-Mar Sci Pharm pmid:21617769
El-Alfy TS et al. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. 2011 Oct-Dec Sci Pharm pmid:22145118
Arya A et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. 2012 Evid Based Complement Alternat Med pmid:22474512
Chen WQ et al. A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. 2012 Bioorg. Med. Chem. Lett. pmid:22901896
Ni F et al. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. 2012 PLoS ONE pmid:22693649
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Lee JM et al. Acute Toxicity and General Pharmacological Action of QGC EXT. 2012 Korean J. Physiol. Pharmacol. pmid:22416220
Wang BL et al. Treating acute cystitis with biodegradable micelle-encapsulated quercetin. 2012 Int J Nanomedicine pmid:22661886
Galindo P et al. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. 2012 PLoS ONE pmid:22427863
Chen HJ et al. Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. 2012 J Ethnopharmacol pmid:22353428
Yang Y et al. Bioactivity-guided fractionation of the triglyceride-lowering component and in vivo and in vitro evaluation of hypolipidemic effects of Calyx seu Fructus Physalis. 2012 Lipids Health Dis pmid:22413998
Lee DH et al. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. 2012 Evid Based Complement Alternat Med pmid:22194772
Lee H et al. Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. 2012 Evid Based Complement Alternat Med pmid:22454682
Kim S et al. Vascular disrupting agent drug classes differ in effects on the cytoskeleton. 2012 PLoS ONE pmid:22848372
Xin HL et al. Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. 2012 Molecules pmid:22832885
Shih TL et al. An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. 2012 Molecules pmid:22777189
Thomas CM et al. Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. 2012 PLoS ONE pmid:22768128
Waki T et al. Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. 2012 Chem. Pharm. Bull. pmid:22223373
Wang YL et al. Anxiolytic-like effects of compound zhi zhu xiang in rats. 2012 Evid Based Complement Alternat Med pmid:22690249
Wang J et al. Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD. 2012 Int J Anal Chem pmid:22654910
Bairwa R et al. Trachyspermum ammi. 2012 Pharmacogn Rev pmid:22654405
Huang Y et al. Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin. 2012 J. Exp. Clin. Cancer Res. pmid:22607709
Joshi SC and Mathela CS Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. 2012 Pharmacognosy Res pmid:22518079
Chantarudee A et al. Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. 2012 BMC Complement Altern Med pmid:22513008
Soumyanath A et al. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. 2012 Int J Alzheimers Dis pmid:22506133
Watts SD et al. A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. 2012 PLoS ONE pmid:22506078
Vermelho AB et al. Microbial enzyme: applications in industry and in bioremediation. 2012 Enzyme Res pmid:22496966
Balboni G et al. Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. 2012 Bioorg. Med. Chem. Lett. pmid:22487176
Walch SG et al. Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. 2012 Anal Chem Insights pmid:22493561
Sun S et al. The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. 2012 Evid Based Complement Alternat Med pmid:22474507
Zandi K et al. Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. 2012 Molecules pmid:22374315
Chen WC et al. Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. 2012 Molecules pmid:22456615
Liu Y et al. Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. 2012 Evid Based Complement Alternat Med pmid:22454656
Yong-Chun J et al. A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. 2012 Pharmacogn Mag pmid:22438662
Zamboni A et al. Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. 2012 BMC Genomics pmid:22433273
Khan R et al. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. 2012 Toxicol. Appl. Pharmacol. pmid:22155348
Kim HG et al. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. 2012 Biol. Pharm. Bull. pmid:22863927
Ilboudo O et al. Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. 2012 Eur J Mass Spectrom (Chichester, Eng) pmid:23221119
Qiao Y et al. [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234130
Murata T et al. Hyaluronidase inhibitors from Keiskea japonica. 2012 Chem. Pharm. Bull. pmid:22223383
Chen YH et al. Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. 2012 Food Chem pmid:23107683
Khan M et al. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. 2012 Evid Based Complement Alternat Med pmid:22216058
Christensen KY et al. The risk of lung cancer related to dietary intake of flavonoids. 2012 Nutr Cancer pmid:23061904
Zielińska D et al. Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. 2012 Molecules pmid:22890171
Buszewski B and Noga S Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. 2012 Anal Bioanal Chem pmid:21879300
Wang D et al. Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. 2012 Oxid Med Cell Longev pmid:22496932
Narwal M et al. Homogeneous screening assay for human tankyrase. 2012 J Biomol Screen pmid:22357873
Sharma M et al. Expression of flavonoid 3'-hydroxylase is controlled by P1, the regulator of 3-deoxyflavonoid biosynthesis in maize. 2012 BMC Plant Biol. pmid:23113982
Hammoud L et al. A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. 2012 Nat. Prod. Res. pmid:21815723
Brito I et al. 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22259537
Gooda Sahib N et al. Plants' metabolites as potential antiobesity agents. 2012 ScientificWorldJournal pmid:22666121
Bandaruk Y et al. Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. 2012 J. Agric. Food Chem. pmid:23009399
Hatnapure GD et al. Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. 2012 Bioorg. Med. Chem. Lett. pmid:22981334
Seki N et al. Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways. 2012 J. Cell. Biochem. pmid:22359269
Hamilton ML et al. Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. 2012 Phytochemistry pmid:22959223
Klier L et al. Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. 2012 J. Am. Chem. Soc. pmid:22860983
Shi Y et al. Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. 2012 Phytother Res pmid:22389128
Kanda K et al. Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. 2012 Biochim. Biophys. Acta pmid:22172985
Mijangos MV et al. Microwave-assisted C-3 selective oxidative radical alkylation of flavones. 2012 Org. Biomol. Chem. pmid:22395456
Ho YC et al. Re-examination of chromogenic quantitative assays for determining flavonoid content. 2012 J. Agric. Food Chem. pmid:22352692
Barros L et al. Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal. 2012 Food Chem. Toxicol. pmid:22342808
Khoobi M et al. A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. 2012 Chem. Commun. (Camb.) pmid:22318701
Lee HJ et al. Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. 2012 Arch. Pharm. Res. pmid:22297755
Spatafora C and Tringali C Natural-derived polyphenols as potential anticancer agents. 2012 Anticancer Agents Med Chem pmid:22292766
de-Faria FM et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. 2012 ScientificWorldJournal pmid:22654592
Lewin G et al. Influence of the skeleton on the cytotoxicity of flavonoids. 2012 Bioorg. Med. Chem. pmid:22257529
Kongkum N et al. DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. 2012 Fitoterapia pmid:22155186
Buchanan CM et al. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. 2012 Clin. Sci. pmid:22142330
Qin S et al. Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. 2012 J Ethnopharmacol pmid:22265932
Vauzour D Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. 2012 Oxid Med Cell Longev pmid:22701758
Rozza AL et al. Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. 2012 Evid Based Complement Alternat Med pmid:22666296
Kim YW et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. 2012 J. Gastroenterol. Hepatol. pmid:21793913
Gates PJ and Lopes NP Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry. 2012 Int J Anal Chem pmid:22505914
Malherbe CJ et al. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. 2012 Int J Mol Sci pmid:22489144
Rahigude A et al. Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. 2012 Neuroscience pmid:22999973
Huang WY et al. Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. 2012 J Zhejiang Univ Sci B pmid:22302422
Kostrzewa-Susłow E and Janeczko T Microbial transformations of 7-hydroxyflavanone. 2012 ScientificWorldJournal pmid:22654578
Zbidah M et al. Apigenin-induced suicidal erythrocyte death. 2012 J. Agric. Food Chem. pmid:22132906
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Palmieri D et al. Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. 2012 Mol. Cell. Biochem. pmid:22899172