FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Asthma D001249 52 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystitis D003556 23 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypertension D006973 115 associated lipids
Leukemia P388 D007941 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Kubo I et al. Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. 2000 Bioorg. Med. Chem. pmid:10976523
Li Y et al. Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. 2000 Clin. Cancer Res. pmid:10656453
Dertinger SD et al. Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. 2000 Biochem. Pharmacol. pmid:10825463
Motwani M et al. Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells. 2000 Clin. Cancer Res. pmid:10741717
Perez RM et al. Isolation and hypoglycemic activity of 5, 7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. 2000 Phytomedicine pmid:10782487
Liu IX et al. Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. 2000 J. Pharm. Pharmacol. pmid:10757427
Schwinger RH et al. Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. 2000 J. Cardiovasc. Pharmacol. pmid:10813370
Wollenweber E et al. Epicuticular flavonoids of some Scrophulariaceae. 2000 Jan-Feb Z. Naturforsch., C, J. Biosci. pmid:10739092
Harris SR et al. Oxidative stress contributes to the anti-proliferative effects of flavone acetic acid on endothelial cells. 2000 Jul-Aug Anticancer Res. pmid:10953282
Shao ZM et al. Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. 2000 Jul-Aug Anticancer Res. pmid:10953303
Baranowska I and Raróg D Application of derivative spectrophotometry to determination of flavonoid mixtures. 2001 Talanta pmid:18968363
Böcker D and Verspohl EJ Role of protein kinase C, PI3-kinase and tyrosine kinase in activation of MAP kinase by glucose and agonists of G-protein coupled receptors in INS-1 cells. 2001 Int. J. Exp. Diabetes Res. pmid:12369712
Saarinen N et al. No evidence for the in vivo activity of aromatase-inhibiting flavonoids. 2001 J. Steroid Biochem. Mol. Biol. pmid:11595503
Seo HJ and Surh YJ Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. 2001 Mutat. Res. pmid:11551495
Andrade-Cetto A and Wiedenfeld H Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. 2001 J Ethnopharmacol pmid:11694359
Hirvonen T et al. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). 2001 Cancer Causes Control pmid:11714106
Philpott M et al. The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor. 2001 Eur. J. Cancer pmid:11576850
Mcmullen MD et al. The biological basis of epistasis between quantitative trait loci for flavone and 3-deoxyanthocyanin synthesis in maize (Zea mays L.). 2001 Genome pmid:11550903
Kumazawa T et al. Synthesis of 8-C-glucosylflavones. 2001 Carbohydr. Res. pmid:11513825
Lee SE et al. Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. 2001 J. Agric. Food Chem. pmid:11714299