| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marczak Å et al. | Fragmentation pathways of acylated flavonoid diglucuronides from leaves of Medicago truncatula. | 2010 May-Jun | Phytochem Anal | pmid:19950391 |
| Modelli A and Pshenichnyuk SA | Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways. | 2013 | Phys Chem Chem Phys | pmid:23243660 |
| Maçanita AL et al. | Photochemistry of flavothione and hydroxyflavothiones: mechanisms and kinetics. | 2003 | Photochem. Photobiol. | pmid:12856878 |
| Huong DT et al. | A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). | 2005 | Pharmazie | pmid:16124409 |
| Tunçbilek M et al. | Synthesis and antioxidant properties of some new flavone derivatives on lipid peroxidation in the rat liver. | 2000 | Pharmazie | pmid:11828615 |
| Kulevanova S et al. | HPLC identification and determination of flavone aglycones in Helichrysum plicatum DC. (Asteraceae). | 2000 | Pharmazie | pmid:11828624 |
| Gabrieli C and Kokkalou E | A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas. | 2003 | Pharmazie | pmid:12857010 |
| Ahlemeyer B and Krieglstein J | Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. | 2003 | Pharmacopsychiatry | pmid:13130383 |
| Friedman FK et al. | Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. | 1985 | Pharmacology | pmid:4059325 |
| Ajay M et al. | Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. | 2007 | Pharmacol. Res. | pmid:17317209 |
| Cho H et al. | Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. | 2004 | Pharmacol. Res. | pmid:14597150 |
| Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
| Fernández S et al. | Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. | 2004 | Pharmacol. Biochem. Behav. | pmid:14751470 |
| Vidyalakshmi K et al. | Antinociceptive effect of certain dihydroxy flavones in mice. | 2010 | Pharmacol. Biochem. Behav. | pmid:20346369 |
| Viola H et al. | 6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity. | 2000 | Pharmacol. Biochem. Behav. | pmid:10672984 |
| Oberpichler H et al. | Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. | 1988 | Pharmacol Res Commun | pmid:3420139 |
| Kasala ER et al. | Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. | 2016 | Pharmacol Rep | pmid:26922533 |
| Shiromwar SS and Chidrawar VR | Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. | 2011 | Pharmacognosy Res | pmid:22022172 |
| Lima de Medeiros BJ et al. | Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). | 2011 | Pharmacognosy Res | pmid:21772750 |
| Thirupathy KP et al. | Neuropharmacological activity of Lippia nodiflora Linn. | 2011 | Pharmacognosy Res | pmid:22022169 |