| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fong YK et al. | In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. | 2012 | J Ethnopharmacol | pmid:21906668 |
| Yamada P et al. | Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells. | 2008 | J Ethnopharmacol | pmid:18178046 |
| Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
| Chen HJ et al. | Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells. | 2012 | J Ethnopharmacol | pmid:22353428 |
| Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stem bark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16448793 |
| Carvalho JC et al. | Anti-inflammatory activity of flavone and some of its derivates from Virola michelli Heckel. | 1999 | J Ethnopharmacol | pmid:10197753 |
| Sandabe UK et al. | Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals. | 2006 | J Ethnopharmacol | pmid:16243463 |
| Bankova V | Chemical diversity of propolis and the problem of standardization. | 2005 | J Ethnopharmacol | pmid:15993016 |
| Andrade-Cetto A and Wiedenfeld H | Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. | 2001 | J Ethnopharmacol | pmid:11694359 |
| Engelbertz J et al. | Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. | 2012 | J Ethnopharmacol | pmid:22465593 |
| La Casa C et al. | Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. | 2000 | J Ethnopharmacol | pmid:10904145 |
| Ortet R et al. | Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. | 2011 | J Ethnopharmacol | pmid:21982788 |
| Qin S et al. | Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. | 2012 | J Ethnopharmacol | pmid:22265932 |
| Blonska M et al. | Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages. | 2004 | J Ethnopharmacol | pmid:15036463 |
| Semwal RB et al. | Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. | 2011 | J Ethnopharmacol | pmid:21354288 |
| Cai RL et al. | Antihypertensive effect of total flavone extracts from Puerariae Radix. | 2011 | J Ethnopharmacol | pmid:20933075 |
| Ramajayam R et al. | Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines. | 2007 | J Enzyme Inhib Med Chem | pmid:18237024 |
| Yadava RN and Tiwari L | New antifungal flavone glycoside from Butea monosperma O. Kuntze. | 2007 | J Enzyme Inhib Med Chem | pmid:17847718 |
| Najmus-Saqib Q et al. | Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla. | 2009 | J Enzyme Inhib Med Chem | pmid:18686139 |
| Ryu YB et al. | Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. | 2008 | J Enzyme Inhib Med Chem | pmid:18608767 |
| Patra JC and Chua BH | Artificial neural network-based drug design for diabetes mellitus using flavonoids. | 2011 | J Comput Chem | pmid:20806262 |
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| Choi EJ and Kim GH | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | 2009 | J Clin Biochem Nutr | pmid:19430615 |
| Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
| Geng X et al. | High selective purification of flavonoids from natural plants based on polymeric adsorbent with hydrogen-bonding interaction. | 2009 | J Chromatogr A | pmid:19837412 |
| Vaher M and Koel M | Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis. | 2003 | J Chromatogr A | pmid:12685601 |
| Boué SM et al. | Identification of flavone aglycones and glycosides in soybean pods by liquid chromatography-tandem mass spectrometry. | 2003 | J Chromatogr A | pmid:12703901 |
| Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
| Cesla P et al. | Optimization of two-dimensional gradient liquid chromatography separations. | 2009 | J Chromatogr A | pmid:18804770 |
| Hamman C et al. | The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules. | 2011 | J Chromatogr A | pmid:21939976 |
| Jandera P et al. | Optimization of separation in two-dimensional high-performance liquid chromatography by adjusting phase system selectivity and using programmed elution techniques. | 2008 | J Chromatogr A | pmid:18067903 |
| Cacciola F et al. | Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. | 2007 | J Chromatogr A | pmid:17331519 |
| Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |
| Wu W et al. | Studies on the flavones using liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 | J Chromatogr A | pmid:15460251 |
| Qi S et al. | Simultaneous determination of bioactive flavone derivatives in Chinese herb extraction by capillary electrophoresis used different electrolyte systems--borate and ionic liquids. | 2006 | J Chromatogr A | pmid:16464459 |
| Villela A et al. | Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld). | 2011 | J Chromatogr A | pmid:21999916 |
| Zgórka G | Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus. | 2006 | J Chromatogr A | pmid:16364344 |
| Kite GC et al. | Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry. | 2006 | J Chromatogr A | pmid:16360661 |
| Wang QE et al. | Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography. | 2004 | J Chromatogr A | pmid:15453418 |
| Kamto EL et al. | Alternating isocratic and step gradient elution high-speed counter-current chromatography for the isolation of minor phenolics from Ormocarpum kirkii bark. | 2017 | J Chromatogr A | pmid:27988077 |
| Li Q et al. | A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. | 2015 | J Chromatogr A | pmid:25892633 |
| Król-Kogus B et al. | Application of one- and two-dimensional high-performance liquid chromatography methodologies for the analysis of C-glycosylflavones from fenugreek seeds. | 2014 | J Chromatogr A | pmid:25282311 |
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| Marrero-Ponce Y | Linear indices of the "molecular pseudograph's atom adjacency matrix": definition, significance-interpretation, and application to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors. | J Chem Inf Comput Sci | pmid:15554670 | |
| Souza J et al. | A study on the antipicornavirus activity of flavonoid compounds (flavones) by using quantum chemical and chemometric methods. | J Chem Inf Comput Sci | pmid:15154785 | |
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