FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Asthma D001249 52 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cystitis D003556 23 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Glioma D005910 112 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypertension D006973 115 associated lipids
Leukemia P388 D007941 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Tamura M et al. Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain. 1994 Jpn. J. Pharmacol. pmid:7990275
Monici M et al. Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. 1993 J. Photochem. Photobiol. B, Biol. pmid:8271117
Valenti P et al. Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. 1993 Anticancer Drug Des. pmid:8251042
Barrellier MT [Lymphedema: is there a treatment?]. 1992 Jan-Feb Rev Med Interne pmid:1410875
Liu H and Wehmeyer KR Solid-phase extraction with supercritical fluid elution as a sample preparation technique for the ultratrace analysis of flavone in blood plasma. 1992 J. Chromatogr. pmid:1400746
Le Bon AM et al. Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. 1992 Chem. Biol. Interact. pmid:1643669
Siess MH et al. Dietary modification of drug-metabolizing enzyme activities: dose-response effect of flavonoids. 1992 J Toxicol Environ Health pmid:1602520
Minagawa N et al. Possible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala. 1992 FEBS Lett. pmid:1318225
Morita K et al. Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells. 1990 Biochem. Biophys. Res. Commun. pmid:1977385
Ibrahim AR and Abul-Hajj YJ Microbiological transformation of flavone and isoflavone. 1990 Xenobiotica pmid:2346033
Desoize B et al. Response of primary tumour, spontaneous metastases and recurrence of Lewis lung carcinoma (3LL) to flavone acetic acid (FAA, LM975). 1989 Nov-Dec Anticancer Res. pmid:2627123
Ferrari F et al. Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. 1989 Planta Med. pmid:17262259
Kerr DJ and Kaye SB Flavone acetic acid--preclinical and clinical activity. 1989 Eur J Cancer Clin Oncol pmid:2680512
Bonnay M et al. [Flavone acetic acid and LY 186641 interfere in various ways in Jaffé's reaction]. 1989 Bull Cancer pmid:2620109
Tranchand B et al. [Phase I pharmacokinetics of flavone-acetic acid]. 1989 Bull Cancer pmid:2620114
Hill S et al. Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. 1989 Eur J Cancer Clin Oncol pmid:2591434
Ching LM and Baguley BC Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). 1989 Eur J Cancer Clin Oncol pmid:2591444
Wu ES et al. Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. 1989 J. Med. Chem. pmid:2909730
Bibby MC et al. Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. 1989 J. Natl. Cancer Inst. pmid:2911084
Lonchampt M et al. Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. 1989 Arzneimittelforschung pmid:2818676