| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Geraets L et al. | Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19292976 |
| Tan WJ et al. | Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei. | 2009 | Nat. Prod. Res. | pmid:19296380 |
| Mohammed MM et al. | New acylated flavone and cyanogenic glycosides from Linum grandiflorum. | 2009 | Nat. Prod. Res. | pmid:19296395 |
| Parekh HS et al. | A new dawn for the use of traditional Chinese medicine in cancer therapy. | 2009 | Mol. Cancer | pmid:19298677 |
| Wang Y et al. | Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. | 2009 | Diabetes | pmid:19324938 |
| Szliszka E et al. | Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). | 2008 | Int J Mol Sci | pmid:19325719 |
| Samee W et al. | 3D-QSAR investigation of synthetic antioxidant chromone derivatives by molecular field analysis. | 2008 | Int J Mol Sci | pmid:19325746 |
| Fassihi A and Sabet R | QSAR study of p56(lck) protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS. | 2008 | Int J Mol Sci | pmid:19325836 |
| Kim KS et al. | Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans. | 2009 | Mol. Cells | pmid:19326082 |
| Chokchaisiri R et al. | Bioactive flavonoids of the flowers of Butea monosperma. | 2009 | Chem. Pharm. Bull. | pmid:19336944 |
| Li ZF et al. | Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis. | 2009 | HBPD INT | pmid:19357036 |
| Fiorentino A et al. | Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits. | 2009 | J. Agric. Food Chem. | pmid:19358604 |
| Putz MV et al. | Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity. | 2009 | Int J Mol Sci | pmid:19399244 |
| Kang HK et al. | Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. | 2009 | Arthritis Res. Ther. | pmid:19405952 |
| Androutsopoulos VP et al. | Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. | 2009 | Oncol. Rep. | pmid:19424633 |
| Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
| Choi EJ and Kim GH | Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 Cells. | 2009 | J Clin Biochem Nutr | pmid:19430615 |
| Bastos ML et al. | Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19450272 |
| Furuta T et al. | Concise synthesis of chafurosides A and B. | 2009 | Org. Lett. | pmid:19473042 |
| Peng H et al. | A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy. | 2009 | PLoS ONE | pmid:19479068 |
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| Masada S et al. | Functional and structural characterization of a flavonoid glucoside 1,6-glucosyltransferase from Catharanthus roseus. | 2009 | Plant Cell Physiol. | pmid:19561332 |
| Shimada T et al. | Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. | 2009 | Chem. Res. Toxicol. | pmid:19563207 |
| Cao H et al. | Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. | 2009 | J. Hazard. Mater. | pmid:19577841 |
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| Chang TS | An updated review of tyrosinase inhibitors. | 2009 | Int J Mol Sci | pmid:19582213 |
| Yamada T et al. | New azaphilones, seco-chaetomugilins A and D, produced by a marine-fish-derived Chaetomium globosum. | 2009 | Mar Drugs | pmid:19597583 |
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| Karvela E et al. | Deployment of response surface methodology to optimise recovery of grape (Vitis vinifera) stem polyphenols. | 2009 | Talanta | pmid:19635365 |
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| Morita K et al. | Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:1977385 |