| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lymphedema | D008209 | 4 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mitchell AE et al. | Isozyme- and gender-specific induction of glutathione S-transferases by flavonoids. | 2007 | Arch. Toxicol. | pmid:17503020 |
| Zamora RodrÃguez ZB et al. | Antioxidant mechanism is involved in the gastroprotective effects of ozonized sunflower oil in ethanol-induced ulcers in rats. | 2007 | Mediators Inflamm. | pmid:17497036 |
| Kostova I et al. | Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors. | 2006 | Bioinorg Chem Appl | pmid:17497014 |
| Ohtani H et al. | Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. | 2007 | Pharm. Res. | pmid:17492365 |
| Yao N et al. | Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. | J Comb Chem | pmid:17487987 | |
| Meyer JD et al. | Quantitative trait loci for maysin synthesis in maize (Zea mays L.) lines selected for high silk maysin content. | 2007 | Theor. Appl. Genet. | pmid:17486311 |
| Patanasethanont D et al. | Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. | 2007 | Eur. J. Pharmacol. | pmid:17481606 |
| Gates MA et al. | A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. | 2007 | Int. J. Cancer | pmid:17471564 |
| Zhang J et al. | Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. | 2007 | Plant Physiol. | pmid:17434990 |
| Govindarajan R et al. | Effect of Desmodium gangeticum extract on blood glucose in rats and on insulin secretion in vitro. | 2007 | Planta Med. | pmid:17431824 |
| do Nascimento AM and de Oliveira DC | A new 5-deoxyflavone glycoside from the aerial parts of Calea clausseniana. | 2007 | Carbohydr. Res. | pmid:17420009 |
| Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
| Ullmannova V and Popescu NC | Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. | 2007 | Cancer Detect. Prev. | pmid:17418982 |
| Nomura T et al. | Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark). | 1983 | Planta Med. | pmid:17405088 |
| Manna SK et al. | Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. | 2007 | Clin. Cancer Res. | pmid:17404114 |
| Lee E et al. | Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404065 |
| Kim MJ et al. | Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404061 |
| Jeong MA et al. | Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404058 |
| Enomoto R et al. | Wogonin prevents immunosuppressive action but not anti-inflammatory effect induced by glucocorticoid. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404053 |
| Forgacs P et al. | [Flavones and Sesquiterpene Lactones of Volutarella divaricata]. | 1981 | Planta Med. | pmid:17401976 |
| Hurabielle M et al. | [Flavonoids of Artemisia campestris, ssp. glutinosa]. | 1982 | Planta Med. | pmid:17396957 |
| Odebiyi OO | Isolation of a new flavone and some essential oils with antimicrobial and antifungal properties from the stem bark of Jatropha podagrica. | 1982 | Planta Med. | pmid:17396821 |
| Cabrera M et al. | Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. | 2007 | Bioorg. Med. Chem. | pmid:17383189 |
| Chen S and Li X | Transposable elements are enriched within or in close proximity to xenobiotic-metabolizing cytochrome P450 genes. | 2007 | BMC Evol. Biol. | pmid:17381843 |
| Lin J et al. | Dietary intakes of flavonols and flavones and coronary heart disease in US women. | 2007 | Am. J. Epidemiol. | pmid:17379619 |
| Ahmed N et al. | Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17379515 |
| Hinnen P and Eskens FA | Vascular disrupting agents in clinical development. | 2007 | Br. J. Cancer | pmid:17375046 |
| Han X et al. | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. | 2007 | J Chromatogr A | pmid:17374377 |
| Aboul-Enein HY et al. | Scavenging effects of phenolic compounds on reactive oxygen species. | 2007 | Biopolymers | pmid:17373654 |
| Ono M | [Molecular imaging of beta-amyloid plaques in the brain]. | 2007 | Brain Nerve | pmid:17370649 |
| Joshi KS et al. | P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. | 2007 | Mol. Cancer Ther. | pmid:17363487 |
| Ko JH et al. | Four glucosyltransferases from rice: cDNA cloning, expression, and characterization. | 2008 | J. Plant Physiol. | pmid:17363107 |
| Duarte-Almeida JM et al. | Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice. | 2007 | Phytochemistry | pmid:17350657 |
| Winkelmann I et al. | The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes. | 2007 | Carcinogenesis | pmid:17347140 |
| Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
| Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
| Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
| Kunnumakkara AB et al. | Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. | 2007 | Blood | pmid:17332240 |
| Cacciola F et al. | Comprehensive two-dimensional liquid chromatography with parallel gradients for separation of phenolic and flavone antioxidants. | 2007 | J Chromatogr A | pmid:17331519 |
| Park H et al. | Anti-inflammatory activity of the synthetic C-C biflavonoids. | 2006 | J. Pharm. Pharmacol. | pmid:17331331 |
| Ajay M et al. | Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid. | 2007 | Pharmacol. Res. | pmid:17317209 |
| Boumendjel A et al. | Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. | 2007 | Bioorg. Med. Chem. | pmid:17317193 |
| Lohner K et al. | Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo. | 2007 | Mol Nutr Food Res | pmid:17295420 |
| Borges-Argáez R et al. | Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp. | 2007 | Phytomedicine | pmid:17291734 |
| Sarkar K et al. | Antibody response against neem leaf preparation recognizes carcinoembryonic antigen. | 2007 | Int. Immunopharmacol. | pmid:17276888 |
| Doronicheva N et al. | Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. | 2007 | Biol. Pharm. Bull. | pmid:17268053 |
| Murakami S et al. | Purification and characterization of three neutral extracellular isoperoxidases from rye leaves. | 2007 | Phytochemistry | pmid:17266998 |
| Ferrari F et al. | Structures of three new flavone derivatives, brosimones G, H, and I, from Brosimopsis oblongifolia. | 1989 | Planta Med. | pmid:17262259 |
| Iida N et al. | A new flavone xyloside and two new flavan-3-ol glucosides from Juniperus communis var. depressa. | 2007 | Chem. Biodivers. | pmid:17256732 |
| Walle T et al. | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. | 2007 | Biochem. Pharmacol. | pmid:17250812 |