| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Glioma | D005910 | 112 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Julião Lde S et al. | Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. | 2010 | Phytochemistry | pmid:19922967 |
| Fekrazad HM et al. | A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer. | 2010 | Am. J. Clin. Oncol. | pmid:19884803 |
| Zhao C et al. | [Study on extraction of anti-diabetes active constituents from Potentilla chinesis]. | 2010 | Zhong Yao Cai | pmid:20575426 |
| Gülcemal D et al. | Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei. | 2010 | Carbohydr. Res. | pmid:20937505 |
| Winkelmann I et al. | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. | 2010 | Mol Nutr Food Res | pmid:20564477 |
| Basile A et al. | Antibacterial and antifungal properties of acetonic extract of Feijoa sellowiana fruits and its effect on Helicobacter pylori growth. | 2010 | J Med Food | pmid:20136454 |
| Seo J et al. | Location of flavone B-ring controls regioselectivity and stereoselectivity of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816-4. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20091026 |
| Wang SQ et al. | Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20932762 |
| Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
| Chatuphonprasert W et al. | Potent modification of inducible CYP1A1 expression by flavonoids. | 2010 | Biol. Pharm. Bull. | pmid:20930378 |
| Jayaraman P et al. | Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro. | 2010 | Int. J. Biol. Sci. | pmid:20941374 |
| Mukai R et al. | Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. | 2010 | Arch. Biochem. Biophys. | pmid:20450880 |
| Jeng YJ et al. | Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol - pituitary tumor induction in Fischer 344 rats. | 2010 | Nutr Metab (Lond) | pmid:20459739 |
| Ci X et al. | Regulation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells by 2''-hydroxy-3''-en-anhydroicaritin involves down-regulation of NF-kappaB and MAPK expression. | 2010 | Int. Immunopharmacol. | pmid:20462523 |
| Qian LB et al. | Luteolin reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta by reducing oxidative stress. | 2010 | Pharmacol. Res. | pmid:19892019 |
| Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
| Zhang Y et al. | Dietary flavonol and flavone intakes and their major food sources in Chinese adults. | 2010 | Nutr Cancer | pmid:21058200 |
| Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
| Huang CH et al. | Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways. | 2010 | J. Food Sci. | pmid:21535503 |
| Xu B and Chang SK | Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. | 2010 | J. Agric. Food Chem. | pmid:20058926 |
| Lakhan SE and Vieira KF | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. | 2010 | Nutr J | pmid:20929532 |
| Fransen HP et al. | Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba. | 2010 | Food Nutr Res | pmid:20927202 |
| Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
| Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
| Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
| Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
| Gao LM and Meléndez E | Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7. | 2010 | Met Based Drugs | pmid:20454639 |
| Kyrgidis A et al. | Melanoma: Stem cells, sun exposure and hallmarks for carcinogenesis, molecular concepts and future clinical implications. | 2010 | J Carcinog | pmid:20442802 |
| Zhuang P et al. | Effect of flavone on the ocular blood flow and formation of choroidal neovascularization. | 2010 | Int J Ophthalmol | pmid:22553528 |
| Semalty M et al. | Semecarpus anacardium Linn.: A review. | 2010 | Pharmacogn Rev | pmid:22228947 |
| Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
| van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
| Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
| Baikar S and Malpathak N | Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. | 2010 | Pharmacogn Rev | pmid:22228937 |
| Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
| Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
| Sabarinathan D et al. | Naringenin promote apoptosis in cerebrally implanted C6 glioma cells. | 2010 | Mol. Cell. Biochem. | pmid:20717707 |
| Alam MS and Lee DU | Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | 2010 | Chem. Pharm. Bull. | pmid:21139271 |
| Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
| Hong TB et al. | Potential effects of chrysin on MDA-MB-231 cells. | 2010 | Int J Mol Sci | pmid:20479999 |
| Perumal Samy R and Gopalakrishnakone P | Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. | 2010 | Evid Based Complement Alternat Med | pmid:18955349 |
| Masoodi TA and Alhamdanz AH | Inhibitory effect of flavonoids on mutant H-Rasp protein. | 2010 | Bioinformation | pmid:21346872 |
| Picon PD et al. | Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. | 2010 | BMC Complement Altern Med | pmid:20433751 |
| Liu XH et al. | Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20538457 |
| Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
| Hori A and Naganuma K | Fully and partially fluorinated flavone derivatives. | 2010 | Acta Crystallogr C | pmid:20442510 |
| Wang H et al. | Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. | 2010 | Asian J. Androl. | pmid:20436506 |
| Kosmider B et al. | Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). | 2010 | Arzneimittelforschung | pmid:20422947 |
| Veitch NC et al. | Flavonoid glycosides of the black locust tree, Robinia pseudoacacia (Leguminosae). | 2010 | Phytochemistry | pmid:19948349 |
| Flora SJ | Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. | 2009 Sep-Oct | Oxid Med Cell Longev | pmid:20716905 |