FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Karton Y et al. Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. 1996 J. Med. Chem. pmid:8691424
Griffin RJ et al. Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. 2005 J. Med. Chem. pmid:15658870
Viswanathan T and Alworth WL Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. 1981 J. Med. Chem. pmid:7277387
Shin W et al. Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. 1995 J. Med. Chem. pmid:7473560
Gobbi S et al. Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. 2006 J. Med. Chem. pmid:16854084
Toulmin A et al. Toward prediction of alkane/water partition coefficients. 2008 J. Med. Chem. pmid:18558667
Ono M et al. Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. 2005 J. Med. Chem. pmid:16279784
Kahnberg P et al. Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. 2002 J. Med. Chem. pmid:12213060
Kim YW et al. Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. 2004 J. Med. Chem. pmid:15267241
El-Subbagh HI et al. Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. 2000 J. Med. Chem. pmid:10956199
Wu ES et al. Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties. 1989 J. Med. Chem. pmid:2909730
Park SR et al. Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering. 2011 J. Microbiol. Biotechnol. pmid:22127124
Jeon YM et al. Biological synthesis of 7-O-methyl Apigenin from naringenin using escherichia coli expressing two genes. 2009 J. Microbiol. Biotechnol. pmid:19494697
Niraula NP et al. Biotransformation of flavone by CYP105P2 from Streptomyces peucetius. 2012 J. Microbiol. Biotechnol. pmid:22713981
Young J et al. Antimicrobial effects of flavone analogues and their structure-activity relationships. 2007 J. Microbiol. Biotechnol. pmid:18050960
Li H et al. Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. 2006 J. Mol. Graph. Model. pmid:16497524
Yang Y et al. Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies. 2010 J. Mol. Graph. Model. pmid:21094069
Díaz F et al. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. 2003 J. Nat. Prod. pmid:12828478
Gleye C et al. Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives. 2003 J. Nat. Prod. pmid:12762809
Gafner S et al. Inhibition of [3H]-LSD binding to 5-HT7 receptors by flavonoids from Scutellaria lateriflora. 2003 J. Nat. Prod. pmid:12713409
Suzuki R et al. Two flavone C-glycosides from the style of Zea mays with glycation inhibitory activity. 2003 J. Nat. Prod. pmid:12713418
Wenzig E et al. Flavonolignans from Avena sativa. 2005 J. Nat. Prod. pmid:15730266
Zhang F et al. Forsythoneosides A-D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa. 2015 J. Nat. Prod. pmid:26422318
Lewin G et al. Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. 2010 J. Nat. Prod. pmid:20356063
Gao F et al. Sesquiterpene lactones and flavonoids from Helianthus species. 1987 Jan-Feb J. Nat. Prod. pmid:3598595
Carcache-Blanco EJ et al. Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. 2003 J. Nat. Prod. pmid:14510596
Rossi M et al. Molecular structure and activity toward DNA of baicalein, a flavone constituent of the Asian herbal medicine "Sho-saiko-to". 2001 J. Nat. Prod. pmid:11170661
Urba WJ et al. Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. 1988 J. Natl. Cancer Inst. pmid:2452890
Rabinovitz M Flavone-8-acetic acid and the natural flavonoids. 1989 J. Natl. Cancer Inst. pmid:2733041
Zwi LJ et al. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. 1989 J. Natl. Cancer Inst. pmid:2733044
Bibby MC et al. Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. 1989 J. Natl. Cancer Inst. pmid:2911084
Hornung RL et al. Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. 1988 J. Natl. Cancer Inst. pmid:3418728
Finlay GJ et al. Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. 1988 J. Natl. Cancer Inst. pmid:3351960
Raza SS et al. Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. 2011 J. Neurol. Sci. pmid:21840019
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Ohchi H et al. Effects of dietary xenobiotics on the metabolism of copper, alpha-tocopherol and cholesterol in rats. 1987 J. Nutr. Sci. Vitaminol. pmid:3125311
Zhao W et al. Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process. 2015 J. Org. Chem. pmid:26291122
Lai MY et al. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. 2003 J. Pharm. Pharmacol. pmid:12631413
Campos DA et al. Gastroprotective effect of a flavone from Lonchocarpus araripensis Benth. (Leguminosae) and the possible mechanism. 2008 J. Pharm. Pharmacol. pmid:18284821
Bovicelli P et al. Efficient synthesis of polyoxygenated flavones from naturally occurring flavanones. 2007 J. Pharm. Pharmacol. pmid:18053332
Sasaki K et al. Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. 2005 J. Pharm. Pharmacol. pmid:15831206
Akao T et al. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. 2000 J. Pharm. Pharmacol. pmid:11197087
Capasso R et al. Inhibition of rat vas deferens contractions by flavonoids in-vitro. 2006 J. Pharm. Pharmacol. pmid:16536906
Liu IX et al. Baicalin synergy with beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus and other beta-lactam-resistant strains of S. aureus. 2000 J. Pharm. Pharmacol. pmid:10757427
Chung MI et al. Synthesis, antiplatelet and vasorelaxing effects of monooxygenated flavones and flavonoxypropanolamines. 2001 J. Pharm. Pharmacol. pmid:11804390
Lim SS et al. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. 2001 J. Pharm. Pharmacol. pmid:11370705
Akao T et al. Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. 2007 J. Pharm. Pharmacol. pmid:17227625
Ji W et al. Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. 2008 J. Pharm. Pharmacol. pmid:18718125
ANREP GV et al. The spasmolytic action of flavone. 1953 J. Pharm. Pharmacol. pmid:13035698
Gautam N et al. In-situ absorption, protein binding and pharmacokinetic studies of S002-853, a novel antidiabetic and antidyslipidaemic flavone derivative in rats. 2010 J. Pharm. Pharmacol. pmid:20609062