| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Glioma | D005910 | 112 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khan MS et al. | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. | 2011 | Chem. Biol. Interact. | pmid:21554863 |
| Lin CC et al. | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | 2011 | Int. J. Oncol. | pmid:21573491 |
| Jeon JG et al. | Natural products in caries research: current (limited) knowledge, challenges and future perspective. | 2011 | Caries Res. | pmid:21576957 |
| van Tonder JH et al. | Tricarbon-yl(η-flavone)chromium(0). | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578102 |
| Aree T et al. | 5,7-Dimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one methanol solvate monohydrate. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578297 |
| Aree T and Sawasdee P | 3,5,7-Trimeth-oxy-2-(4-methoxy-phen-yl)-4H-1-benzopyran-4-one. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578306 |
| Xiong HP et al. | 5,7-Dihydr-oxy-3,6,8-trimethoxy-flavone. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21578970 |
| Janeczko T et al. | 2-(4-Bromo-phen-yl)-6-methyl-4H-1-benzopyran-4-one (4'-bromo-6-methyl-flavone). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21580767 |
| Liu B and Yang BL | Hexaaqua-(5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)calcium(II) 5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate trihydrate. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581174 |
| Liu B and Yang BL | Poly[(μ-5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)potassium(I)]. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21581534 |
| Yob NJ et al. | Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. | 2011 | Evid Based Complement Alternat Med | pmid:21584247 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| van Tonder JH et al. | Racemic tricarbonyl[(4a,5,6,7,8,8a-η)-2-phenyl-3,4-dihydro-2H-1-benzopyran]chromium(0). | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21588503 |
| Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
| Yao N et al. | Novel flavonoids with antiproliferative activities against breast cancer cells. | 2011 | J. Med. Chem. | pmid:21599001 |
| Ono M and Saji H | SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. | 2011 | Int J Mol Imaging | pmid:21603239 |
| Vitalini S et al. | Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. | 2011 | Phytochemistry | pmid:21612805 |
| Chou ST et al. | Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. | 2011 | Anticancer Res. | pmid:21617225 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
| Seo J et al. | Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21626021 |
| Lei W et al. | Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge. | 2010 | Genet. Mol. Biol. | pmid:21637484 |
| Nerurkar PV et al. | Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. | 2011 | J Neuroinflammation | pmid:21639917 |
| Said SA | Two new special flavones from Uvaria accuminata. | 2011 | Nat. Prod. Res. | pmid:21644179 |
| Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
| Guo AJ et al. | Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | 2011 | J. Biol. Chem. | pmid:21652696 |
| Jiang DP et al. | Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells. | 2011 | J. Korean Med. Sci. | pmid:21655064 |
| Quintão NL et al. | Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers. | 2011 | Evid Based Complement Alternat Med | pmid:21660087 |
| Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
| Subbarao PG and Ashok P | Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. | 2011 | J Pharm Bioallied Sci | pmid:21687351 |
| Khan SI et al. | Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. | 2011 | Reprod. Biol. Endocrinol. | pmid:21693041 |
| Sharma RD et al. | Possible implication of oxidative stress in anti filarial effect of certain traditionally used medicinal plants in vitro against Brugia malayi microfilariae. | 2010 | Pharmacognosy Res | pmid:21713137 |
| Li D et al. | Transcriptional profiling of Medicago truncatula under salt stress identified a novel CBF transcription factor MtCBF4 that plays an important role in abiotic stress responses. | 2011 | BMC Plant Biol. | pmid:21718548 |
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
| Prajapati RP et al. | Phytochemical and pharmacological review of Lagenaria sicereria. | 2010 | J Ayurveda Integr Med | pmid:21731373 |
| Wang XX et al. | Simultaneous structural identification of natural products in fractions of crude extract of the rare endangered plant Anoectochilus roxburghii using H NMR/RRLC-MS parallel dynamic spectroscopy. | 2011 | Int J Mol Sci | pmid:21731458 |
| Maher P et al. | Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. | 2011 | PLoS ONE | pmid:21738623 |
| Bojić M et al. | Evaluation of antiaggregatory activity of flavonoid aglycone series. | 2011 | Nutr J | pmid:21745360 |
| Bensasson RV et al. | Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. | 2011 | Free Radic. Biol. Med. | pmid:21745563 |
| Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
| Gohain M et al. | Racemic tricarbon-yl[7-meth-oxy-2-(η-phen-yl)chromane]-chromium(0). | 2011 | Acta Crystallogr Sect E Struct Rep Online | pmid:21753961 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
| Lima de Medeiros BJ et al. | Liver protective activity of a hydroethanolic extract of Arrabidaea chica (Humb. and Bonpl.) B. Verl. (pariri). | 2011 | Pharmacognosy Res | pmid:21772750 |
| Polier G et al. | Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. | 2011 | Cell Death Dis | pmid:21776020 |
| Tan W et al. | Anti-cancer natural products isolated from chinese medicinal herbs. | 2011 | Chin Med | pmid:21777476 |
| Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
| Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
| Tsui KH et al. | Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. | 2012 | Int. J. Cancer | pmid:21780100 |