| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Glioma | D005910 | 112 associated lipids |
FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
| Fong YK et al. | In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein. | 2012 | J Ethnopharmacol | pmid:21906668 |
| Wei Z et al. | Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. | 2012 | J. Biochem. Mol. Toxicol. | pmid:22696397 |
| Ni F et al. | Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. | 2012 | PLoS ONE | pmid:22693649 |
| Chen CC et al. | Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. | 2012 | PLoS ONE | pmid:22272328 |
| Wang BL et al. | Treating acute cystitis with biodegradable micelle-encapsulated quercetin. | 2012 | Int J Nanomedicine | pmid:22661886 |
| Lee DH et al. | Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22194772 |
| Lee H et al. | Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. | 2012 | Evid Based Complement Alternat Med | pmid:22454682 |
| Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
| Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
| Shih TL et al. | An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. | 2012 | Molecules | pmid:22777189 |
| Thomas CM et al. | Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. | 2012 | PLoS ONE | pmid:22768128 |
| Waki T et al. | Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. | 2012 | Chem. Pharm. Bull. | pmid:22223373 |
| Wang YL et al. | Anxiolytic-like effects of compound zhi zhu xiang in rats. | 2012 | Evid Based Complement Alternat Med | pmid:22690249 |
| Wang J et al. | Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD. | 2012 | Int J Anal Chem | pmid:22654910 |
| Joshi SC and Mathela CS | Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. | 2012 | Pharmacognosy Res | pmid:22518079 |
| Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
| Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
| Watts SD et al. | A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. | 2012 | PLoS ONE | pmid:22506078 |
| Vermelho AB et al. | Microbial enzyme: applications in industry and in bioremediation. | 2012 | Enzyme Res | pmid:22496966 |
| Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
| Walch SG et al. | Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. | 2012 | Anal Chem Insights | pmid:22493561 |
| Sun S et al. | The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. | 2012 | Evid Based Complement Alternat Med | pmid:22474507 |
| Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
| Chen WC et al. | Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. | 2012 | Molecules | pmid:22456615 |
| Liu Y et al. | Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. | 2012 | Evid Based Complement Alternat Med | pmid:22454656 |
| Yong-Chun J et al. | A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. | 2012 | Pharmacogn Mag | pmid:22438662 |
| Zamboni A et al. | Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. | 2012 | BMC Genomics | pmid:22433273 |
| Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
| Shi L et al. | Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. | 2012 | Cell. Mol. Neurobiol. | pmid:21984341 |
| Ilboudo O et al. | Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. | 2012 | Eur J Mass Spectrom (Chichester, Eng) | pmid:23221119 |
| Qiao Y et al. | [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234130 |
| Murata T et al. | Hyaluronidase inhibitors from Keiskea japonica. | 2012 | Chem. Pharm. Bull. | pmid:22223383 |
| Chen YH et al. | Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. | 2012 | Food Chem | pmid:23107683 |
| Khan M et al. | Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. | 2012 | Evid Based Complement Alternat Med | pmid:22216058 |
| Christensen KY et al. | The risk of lung cancer related to dietary intake of flavonoids. | 2012 | Nutr Cancer | pmid:23061904 |
| Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
| Buszewski B and Noga S | Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. | 2012 | Anal Bioanal Chem | pmid:21879300 |
| Wang D et al. | Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. | 2012 | Oxid Med Cell Longev | pmid:22496932 |
| Chan LP et al. | Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin. | 2012 | Biochim. Biophys. Acta | pmid:22554915 |
| Cai M et al. | The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. | 2012 | Eur. J. Pharmacol. | pmid:22683875 |
| Wang Y et al. | Flavone C-glycosides from the leaves of Lophatherum gracile and their in vitro antiviral activity. | 2012 | Planta Med. | pmid:21870321 |
| Brito I et al. | 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22259537 |
| Gooda Sahib N et al. | Plants' metabolites as potential antiobesity agents. | 2012 | ScientificWorldJournal | pmid:22666121 |
| Hatnapure GD et al. | Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22981334 |
| Hamilton ML et al. | Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. | 2012 | Phytochemistry | pmid:22959223 |
| Klier L et al. | Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. | 2012 | J. Am. Chem. Soc. | pmid:22860983 |
| Kim D et al. | Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. | 2012 | Org. Biomol. Chem. | pmid:22850763 |
| Jansakul C et al. | Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. | 2012 | Eur. J. Pharmacol. | pmid:22800934 |
| Ulrich-Merzenich G et al. | Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine. | 2012 | Phytomedicine | pmid:22743246 |
| Wilczańska-Barska A et al. | Enhanced accumulation of secondary metabolites in hairy root cultures of Scutellaria lateriflora following elicitation. | 2012 | Biotechnol. Lett. | pmid:22639092 |
| Surichan S et al. | Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. | 2012 | Food Chem. Toxicol. | pmid:22743247 |
| de-Faria FM et al. | Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. | 2012 | ScientificWorldJournal | pmid:22654592 |
| Li G et al. | Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. | 2012 | Fitoterapia | pmid:22056665 |
| Kongkum N et al. | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. | 2012 | Fitoterapia | pmid:22155186 |
| Buchanan CM et al. | DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. | 2012 | Clin. Sci. | pmid:22142330 |
| Park NI et al. | Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. | 2012 | Biotechnol. Lett. | pmid:22113884 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Rozza AL et al. | Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. | 2012 | Evid Based Complement Alternat Med | pmid:22666296 |
| Lolli G et al. | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. | 2012 | Biochemistry | pmid:22794353 |
| Gates PJ and Lopes NP | Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry. | 2012 | Int J Anal Chem | pmid:22505914 |
| Malherbe CJ et al. | Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. | 2012 | Int J Mol Sci | pmid:22489144 |
| Lin TY et al. | Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22759588 |
| Pohanka M | Antioxidants countermeasures against sulfur mustard. | 2012 | Mini Rev Med Chem | pmid:22512566 |
| Begum N et al. | Apigenin ameliorates gamma radiation-induced cytogenetic alterations in cultured human blood lymphocytes. | 2012 | Mutat. Res. | pmid:22516036 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| Kostrzewa-Susłow E and Janeczko T | Microbial transformations of 7-hydroxyflavanone. | 2012 | ScientificWorldJournal | pmid:22654578 |
| Zbidah M et al. | Apigenin-induced suicidal erythrocyte death. | 2012 | J. Agric. Food Chem. | pmid:22132906 |
| Xie C et al. | The açaà flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. | 2012 | J. Nutr. Biochem. | pmid:22137267 |
| Palmieri D et al. | Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. | 2012 | Mol. Cell. Biochem. | pmid:22899172 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| Barrero RA et al. | De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. | 2011 | BMC Genomics | pmid:22151917 |
| Kloska A et al. | Effects of flavonoids on glycosaminoglycan synthesis: implications for substrate reduction therapy in Sanfilippo disease and other mucopolysaccharidoses. | 2011 | Metab Brain Dis | pmid:21305347 |
| Zuk M et al. | Flavonoid engineering of flax potentiate its biotechnological application. | 2011 | BMC Biotechnol. | pmid:21276227 |
| Asakawa T et al. | PET imaging of nobiletin based on a practical total synthesis. | 2011 | Chem. Commun. (Camb.) | pmid:21243163 |
| Xiao J et al. | Noncovalent interaction of dietary polyphenols with common human plasma proteins. | 2011 | J. Agric. Food Chem. | pmid:21863815 |
| Raza SS et al. | Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. | 2011 | J. Neurol. Sci. | pmid:21840019 |
| Yang C et al. | Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. | 2011 | PLoS ONE | pmid:21779360 |
| Janovick JA et al. | Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. | 2011 | PLoS ONE | pmid:21818389 |
| Han S et al. | Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet. | 2011 | Nutr Res Pract | pmid:21779522 |
| Saeidnia S et al. | A review on phytochemistry and medicinal properties of the genus Achillea. | 2011 | Daru | pmid:22615655 |
| Garateix A et al. | Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B. | 2011 | Mol Pain | pmid:21261973 |
| Casati P et al. | Rapid Maize Leaf and Immature Ear Responses to UV-B Radiation. | 2011 | Front Plant Sci | pmid:22666224 |
| Cai H et al. | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). | 2011 | Cancer Chemother. Pharmacol. | pmid:20364427 |
| Theoharides TC and Zhang B | Neuro-inflammation, blood-brain barrier, seizures and autism. | 2011 | J Neuroinflammation | pmid:22129087 |
| Hämäläinen M et al. | Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. | 2011 | Planta Med. | pmid:21341175 |
| Gao L et al. | 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21843936 |
| Phromnoi K et al. | Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. | 2011 | Mol. Pharmacol. | pmid:21816954 |
| Kundu R et al. | Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. | 2011 | Biochem. Pharmacol. | pmid:21801714 |
| Uchi H et al. | A clinical trial of kampo formulae for the treatment of symptoms of yusho, a poisoning caused by dioxins and related organochlorine compounds. | 2011 | Evid Based Complement Alternat Med | pmid:19996156 |
| Larroque-Lombard AL et al. | Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK. | 2011 | Chem Biol Drug Des | pmid:21294849 |
| Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
| Mehla R et al. | A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. | 2011 | PLoS ONE | pmid:22140483 |
| Kang KP et al. | Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. | 2011 | Nephrol. Dial. Transplant. | pmid:20817674 |
| Lefort EC and Blay J | The dietary flavonoid apigenin enhances the activities of the anti-metastatic protein CD26 on human colon carcinoma cells. | 2011 | Clin. Exp. Metastasis | pmid:21298326 |
| Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
| Patra JC and Chua BH | Artificial neural network-based drug design for diabetes mellitus using flavonoids. | 2011 | J Comput Chem | pmid:20806262 |
| Samarghandian S et al. | Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. | 2011 | Clinics (Sao Paulo) | pmid:21808878 |
| Fang W et al. | Flavonoids from the aerial parts of Macrothelypteris torresiana. | 2011 | Nat. Prod. Res. | pmid:21240759 |