FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

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Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Arya A et al. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. 2012 Evid Based Complement Alternat Med pmid:22474512
Chen WQ et al. A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. 2012 Bioorg. Med. Chem. Lett. pmid:22901896
Ni F et al. Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. 2012 PLoS ONE pmid:22693649
Chen CC et al. Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury. 2012 PLoS ONE pmid:22272328
Wang BL et al. Treating acute cystitis with biodegradable micelle-encapsulated quercetin. 2012 Int J Nanomedicine pmid:22661886
Lee DH et al. Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells. 2012 Evid Based Complement Alternat Med pmid:22194772
Lee H et al. Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. 2012 Evid Based Complement Alternat Med pmid:22454682
Collins-Burow BM et al. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. 2012 J. Steroid Biochem. Mol. Biol. pmid:22634477
Yuqing Z et al. Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate. 2012 Int. J. Biol. Macromol. pmid:22575392
Kim S et al. Vascular disrupting agent drug classes differ in effects on the cytoskeleton. 2012 PLoS ONE pmid:22848372
Xin HL et al. Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. 2012 Molecules pmid:22832885
Fan Y et al. Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine. 2012 Int. J. Biol. Macromol. pmid:22020157
Shih TL et al. An alternative synthesis of 3',4'-diaminoflavones to evaluate their antioxidant ability and cell apoptosis of zebrafish larvae. 2012 Molecules pmid:22777189
Thomas CM et al. Anti-neoplastic activity of two flavone isomers derived from Gnaphalium elegans and Achyrocline bogotensis. 2012 PLoS ONE pmid:22768128
Zhou G and Lv G [Comparative studies on scavenging DPPH free radicals activity of flavone C-glycosides from different parts of Dendrobium officinale]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22993976
Waki T et al. Key role of chemical hardness to compare 2,2-diphenyl-1-picrylhydrazyl radical scavenging power of flavone and flavonol O-glycoside and C-glycoside derivatives. 2012 Chem. Pharm. Bull. pmid:22223373
Lies B et al. Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells. 2012 Mol Nutr Food Res pmid:22965487
Wang YL et al. Anxiolytic-like effects of compound zhi zhu xiang in rats. 2012 Evid Based Complement Alternat Med pmid:22690249
Wang J et al. Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD. 2012 Int J Anal Chem pmid:22654910
Chantarudee A et al. Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. 2012 BMC Complement Altern Med pmid:22513008
Soumyanath A et al. Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. 2012 Int J Alzheimers Dis pmid:22506133
Watts SD et al. A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. 2012 PLoS ONE pmid:22506078
Vermelho AB et al. Microbial enzyme: applications in industry and in bioremediation. 2012 Enzyme Res pmid:22496966
Walch SG et al. Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy. 2012 Anal Chem Insights pmid:22493561
Sun S et al. The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. 2012 Evid Based Complement Alternat Med pmid:22474507
Chen WC et al. Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. 2012 Molecules pmid:22456615
Liu Y et al. Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies. 2012 Evid Based Complement Alternat Med pmid:22454656
Yong-Chun J et al. A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China. 2012 Pharmacogn Mag pmid:22438662
Zamboni A et al. Genome-wide microarray analysis of tomato roots showed defined responses to iron deficiency. 2012 BMC Genomics pmid:22433273
Khan R et al. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. 2012 Toxicol. Appl. Pharmacol. pmid:22155348
Kim HG et al. Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. 2012 Biol. Pharm. Bull. pmid:22863927
Shi L et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. 2012 Cell. Mol. Neurobiol. pmid:21984341
Ilboudo O et al. Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. 2012 Eur J Mass Spectrom (Chichester, Eng) pmid:23221119
Qiao Y et al. [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234130
Murata T et al. Hyaluronidase inhibitors from Keiskea japonica. 2012 Chem. Pharm. Bull. pmid:22223383
Chen YH et al. Evaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae. 2012 Food Chem pmid:23107683
Khan M et al. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. 2012 Evid Based Complement Alternat Med pmid:22216058
Christensen KY et al. The risk of lung cancer related to dietary intake of flavonoids. 2012 Nutr Cancer pmid:23061904
Buszewski B and Noga S Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. 2012 Anal Bioanal Chem pmid:21879300
Wang D et al. Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms. 2012 Oxid Med Cell Longev pmid:22496932
Brito I et al. 4',5-Dihy-droxy-7-meth-oxy-flavanone dihydrate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22259537
Gooda Sahib N et al. Plants' metabolites as potential antiobesity agents. 2012 ScientificWorldJournal pmid:22666121
Bandaruk Y et al. Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. 2012 J. Agric. Food Chem. pmid:23009399
Hatnapure GD et al. Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent. 2012 Bioorg. Med. Chem. Lett. pmid:22981334
Hamilton ML et al. Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development. 2012 Phytochemistry pmid:22959223
Klier L et al. Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. 2012 J. Am. Chem. Soc. pmid:22860983
Kim D et al. Synthetic approach to flavanones and flavones via ligand-free palladium(II)-catalyzed conjugate addition of arylboronic acids to chromones. 2012 Org. Biomol. Chem. pmid:22850763
Jansakul C et al. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. 2012 Eur. J. Pharmacol. pmid:22800934
Kanda K et al. Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. 2012 Biochim. Biophys. Acta pmid:22172985
Khoobi M et al. A facile route to flavone and neoflavone backbones via a regioselective palladium catalyzed oxidative Heck reaction. 2012 Chem. Commun. (Camb.) pmid:22318701
Lee HJ et al. Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. 2012 Arch. Pharm. Res. pmid:22297755
Spatafora C and Tringali C Natural-derived polyphenols as potential anticancer agents. 2012 Anticancer Agents Med Chem pmid:22292766
de-Faria FM et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. 2012 ScientificWorldJournal pmid:22654592
Li G et al. Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. 2012 Fitoterapia pmid:22056665
Lewin G et al. Influence of the skeleton on the cytotoxicity of flavonoids. 2012 Bioorg. Med. Chem. pmid:22257529
Kongkum N et al. DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata. 2012 Fitoterapia pmid:22155186
Buchanan CM et al. DMXAA (Vadimezan, ASA404) is a multi-kinase inhibitor targeting VEGFR2 in particular. 2012 Clin. Sci. pmid:22142330
Park NI et al. Enhancement of rutin in Fagopyrum esculentum hairy root cultures by the Arabidopsis transcription factor AtMYB12. 2012 Biotechnol. Lett. pmid:22113884
Qin S et al. Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. 2012 J Ethnopharmacol pmid:22265932
Vauzour D Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. 2012 Oxid Med Cell Longev pmid:22701758
Rozza AL et al. Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. 2012 Evid Based Complement Alternat Med pmid:22666296
Lolli G et al. Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. 2012 Biochemistry pmid:22794353
Gates PJ and Lopes NP Characterisation of flavonoid aglycones by negative ion chip-based nanospray tandem mass spectrometry. 2012 Int J Anal Chem pmid:22505914
Malherbe CJ et al. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. 2012 Int J Mol Sci pmid:22489144
Lin TY et al. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. 2012 Toxicol. Appl. Pharmacol. pmid:22759588
Rahigude A et al. Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats. 2012 Neuroscience pmid:22999973
Kostrzewa-Susłow E and Janeczko T Microbial transformations of 7-hydroxyflavanone. 2012 ScientificWorldJournal pmid:22654578
Zbidah M et al. Apigenin-induced suicidal erythrocyte death. 2012 J. Agric. Food Chem. pmid:22132906
Xie C et al. The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway. 2012 J. Nutr. Biochem. pmid:22137267
Palmieri D et al. Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement. 2012 Mol. Cell. Biochem. pmid:22899172
El-Alfy TS et al. A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. 2011 Oct-Dec Sci Pharm pmid:22145118
Zhao E and Mu Q Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. 2011 Jan-Mar Sci Pharm pmid:21617769
Bredebach M et al. Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin. 2011 Phytochemistry pmid:21353683
Wu LZ et al. Two new flavone C-glycosides from Trollius ledebourii. 2011 Chem. Pharm. Bull. pmid:22041076
Wu B and Wang J Phenolic compounds from Selaginella moellendorfii. 2011 Chem. Biodivers. pmid:21922662
Barrero RA et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. 2011 BMC Genomics pmid:22151917
Mladěnka P et al. In vitro analysis of iron chelating activity of flavonoids. 2011 J. Inorg. Biochem. pmid:21450273
Nagib DA and MacMillan DW Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. 2011 Nature pmid:22158245
Janovick JA et al. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. 2011 PLoS ONE pmid:21818389
Pham MH et al. Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice. 2011 Drug Metab Lett pmid:21457135
Rasoanaivo P et al. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. 2011 Malar. J. pmid:21411015
Theoharides TC and Zhang B Neuro-inflammation, blood-brain barrier, seizures and autism. 2011 J Neuroinflammation pmid:22129087
Novy P et al. In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. 2011 J. Antimicrob. Chemother. pmid:21421582
Ren L et al. Effects of flavone 6-substitutions on GABAA receptors efficacy. 2011 Eur. J. Pharmacol. pmid:21914441
Tayarani-Najaran Z et al. Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines. 2011 Evid Based Complement Alternat Med pmid:20028719
Shin SY et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities. 2011 Bioorg. Med. Chem. Lett. pmid:21907578
Kochevenko A and Fernie AR The genetic architecture of branched-chain amino acid accumulation in tomato fruits. 2011 J. Exp. Bot. pmid:21436187
Ortet R et al. Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. 2011 J Ethnopharmacol pmid:21982788
Phromnoi K et al. Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1. 2011 Mol. Pharmacol. pmid:21816954
Shi G et al. Molecular characteristics and antitumor capacity of Glycan extracted from Cynomorium songaricum. 2011 Int. J. Biol. Macromol. pmid:21396396
Jin J et al. Design, synthesis and biological evaluation of new arylpiperazine derivatives bearing a flavone moiety as α1-adrenoceptor antagonists. 2011 Bioorg. Med. Chem. Lett. pmid:21236664
Li LJ et al. Flavans from the leaf of Ilex centrochinensis. 2011 J Asian Nat Prod Res pmid:21462042
Kim JY et al. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. 2011 J. Agric. Food Chem. pmid:21434689
Baxter A et al. Non-covalent inhibitors of rhinovirus 3C protease. 2011 Bioorg. Med. Chem. Lett. pmid:21183345
Mehla R et al. A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function. 2011 PLoS ONE pmid:22140483
Cai RL et al. Antihypertensive effect of total flavone extracts from Puerariae Radix. 2011 J Ethnopharmacol pmid:20933075
Pan SY et al. New perspectives on chinese herbal medicine (zhong-yao) research and development. 2011 Evid Based Complement Alternat Med pmid:21785622
Wang YJ et al. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. 2011 Regul. Toxicol. Pharmacol. pmid:20920542
Samarghandian S et al. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. 2011 Clinics (Sao Paulo) pmid:21808878
Xiao J et al. Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships. 2011 Integr Biol (Camb) pmid:21947088