FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Li YR et al. Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. 2016 Cancer Biol. Ther. pmid:26569090
Bugel SM et al. Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. 2016 Toxicol. Sci. pmid:27492224
Yan X et al. 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. 2016 Sci Rep pmid:27306715
Lameiras P and Nuzillard JM Highly Viscous Binary Solvents: DMSO-d6/Glycerol and DMSO-d6/Glycerol-d8 for Polar and Apolar Mixture Analysis by NMR. 2016 Anal. Chem. pmid:27008506
Zhu W et al. Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells. 2016 In Vitro Cell. Dev. Biol. Anim. pmid:26935193
Kasala ER et al. Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. 2016 Pharmacol Rep pmid:26922533
Kant R et al. Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities. 2016 Eur J Med Chem pmid:26922227
Zhang J et al. A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity. 2016 Talanta pmid:26695232
Malkhasian AY and Howlin BJ Docking and DFT studies on ligand binding to Quercetin 2,3-dioxygenase. 2016 J. Biomol. Struct. Dyn. pmid:26599260
LeJeune TM et al. Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. 2015 PLoS ONE pmid:26606169
Jian J et al. Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. 2015 Drug Des Devel Ther pmid:26604691
Real Hernandez LM et al. Berry Phenolic Compounds Increase Expression of Hepatocyte Nuclear Factor-1α (HNF-1α) in Caco-2 and Normal Colon Cells Due to High Affinities with Transcription and Dimerization Domains of HNF-1α. 2015 PLoS ONE pmid:26413797
Weng Z et al. The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. 2015 J. Allergy Clin. Immunol. pmid:25498791
Lin CH et al. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. 2015 BMC Cancer pmid:26675309
Nakamura K et al. Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. 2015 Biol. Pharm. Bull. pmid:25810454
Yao X et al. The changes in quality ingredients of Qi chrysanthemum flowers treated with elevated UV-B radiation at different growth stages. 2015 J. Photochem. Photobiol. B, Biol. pmid:25792150
Wang RL et al. A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification. 2015 J. Insect Physiol. pmid:25783953
Zhu W et al. Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. 2015 Biochem. Biophys. Res. Commun. pmid:25680459
Zheng ZP et al. Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions. 2015 J. Agric. Food Chem. pmid:25603116
Ting Y et al. Influence of processing parameters on morphology of polymethoxyflavone in emulsions. 2015 J. Agric. Food Chem. pmid:25537008