FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Liu LZ et al. Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. 2011 Biochem. Biophys. Res. Commun. pmid:21893035
Singh S et al. 2-(4-Chloro-phen-yl)chromen-4-one. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22199687
Zandi K et al. Antiviral activity of four types of bioflavonoid against dengue virus type-2. 2011 Virol. J. pmid:22201648
Bhavsar AS et al. A review on recent advances in dry eye: Pathogenesis and management. 2011 Oman J Ophthalmol pmid:21897618
Manna P et al. Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. 2011 Evid Based Complement Alternat Med pmid:21869899
Lee KN et al. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. 2011 J. Korean Med. Sci. pmid:21860559
Tahanian E et al. Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. 2011 Drug Des Devel Ther pmid:21625419
Ono M and Saji H SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques. 2011 Int J Mol Imaging pmid:21603239
Seo S et al. Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus. 2011 Plant Physiol. pmid:21075959
Wootten D et al. Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids. 2011 J. Pharmacol. Exp. Ther. pmid:21075839
Lewin G et al. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. 2011 Bioorg. Med. Chem. pmid:21146994
Flemmig J et al. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. 2011 Phytomedicine pmid:21144719
Vitalini S et al. Primula spectabilis Tratt. aerial parts: morphology, volatile compounds and flavonoids. 2011 Phytochemistry pmid:21612805
Yin Y et al. Jaceosidin inhibits contact hypersensitivity in mice via down-regulating IFN-γ/STAT1/T-bet signaling in T cells. 2011 Eur. J. Pharmacol. pmid:21093428
Enomoto R et al. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. 2011 Cancer Chemother. Pharmacol. pmid:20658136
Varma A et al. Andrographolide: a new plant-derived antineoplastic entity on horizon. 2011 Evid Based Complement Alternat Med pmid:19752167
Said SA Two new special flavones from Uvaria accuminata. 2011 Nat. Prod. Res. pmid:21644179
Seo J et al. Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. 2011 Appl. Microbiol. Biotechnol. pmid:21626021
Chou ST et al. Zanthoxylum ailanthoides Sieb and Zucc. extract inhibits growth and induces cell death through G2/M-phase arrest and activation of apoptotic signals in colo 205 human colon adenocarcinoma cells. 2011 Anticancer Res. pmid:21617225
Cai WJ et al. Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. 2011 PLoS ONE pmid:22216122