FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

Cross Reference

Introduction

To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with FLAVONE?

FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with FLAVONE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Glioma D005910 112 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with FLAVONE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with FLAVONE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with FLAVONE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with FLAVONE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with FLAVONE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with FLAVONE?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Disease model

Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Animal Disease Models

Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with FLAVONE

Download all related citations
Per page 10 20 50 100 | Total 1492
Authors Title Published Journal PubMed Link
Golub AG et al. Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. 2013 Bioorg. Med. Chem. pmid:24011954
Wiejak J et al. Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. 2013 Biochem. J. pmid:23782265
D'Abrosca B et al. A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. 2013 Nat. Prod. Res. pmid:22708583
Choe H et al. Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL. 2013 Bioorg. Med. Chem. Lett. pmid:23790540
Richter D et al. Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. 2013 Nutr Cancer pmid:23859042
Hapuarachchi SD et al. Andrographidine G, a new flavone glucoside from Andrographis paniculata. 2013 Nat Prod Commun pmid:23678804
Yin FZ et al. [Optimization of preparation of salt-processed psoraleae fructus medicines with multi-index orthogonal method]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23668006
Zhang JY et al. [Rapid recognition and identification of chemical constituents in Qinghuo Zhimai tablets by SPE-HPLC-ESI-MS(n)]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23672039
Chen WQ et al. A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii. 2012 Bioorg. Med. Chem. Lett. pmid:22901896
Lee H et al. Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. 2012 Evid Based Complement Alternat Med pmid:22454682
Sun S et al. The evaluation of chinese therapeutic food for the treatment of moderate dyslipidemia. 2012 Evid Based Complement Alternat Med pmid:22474507
Chen WC et al. Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. 2012 Molecules pmid:22456615
Ilboudo O et al. Targeting structural motifs of flavonoid diglycosides using collision-induced dissociation experiments on flavonoid/Pb2+ complexes. 2012 Eur J Mass Spectrom (Chichester, Eng) pmid:23221119
Qiao Y et al. [Chemical constituents of n-BuOH extract of Comastoma pedunculatum]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234130
Khan M et al. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. 2012 Evid Based Complement Alternat Med pmid:22216058
Buszewski B and Noga S Hydrophilic interaction liquid chromatography (HILIC)--a powerful separation technique. 2012 Anal Bioanal Chem pmid:21879300
Gooda Sahib N et al. Plants' metabolites as potential antiobesity agents. 2012 ScientificWorldJournal pmid:22666121
Lewin G et al. Influence of the skeleton on the cytotoxicity of flavonoids. 2012 Bioorg. Med. Chem. pmid:22257529
Qin S et al. Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein. 2012 J Ethnopharmacol pmid:22265932
Rozza AL et al. Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. 2012 Evid Based Complement Alternat Med pmid:22666296