FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kuo SM | Transepithelial transport and accumulation of flavone in human intestinal Caco-2 cells. | 1998 | Life Sci. | pmid:9877222 |
Matusuura S et al. | [Synthesis studies of the flavone derivates. III. Photochemical reaction of chalcone derivative (author's transl)]. | 1976 | Yakugaku Zasshi | pmid:986458 |
Bai F et al. | Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. | 1998 | FEBS Lett. | pmid:9804172 |
Zhai S et al. | Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes. | 1998 | Life Sci. | pmid:9718089 |
Belinky PA et al. | The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. | 1998 | Atherosclerosis | pmid:9568736 |
Kitajima-Ihara T and Yagi T | Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria: the enzyme expressed in Escherichia coli acts as a member of the respiratory chain in the host cells. | 1998 | FEBS Lett. | pmid:9462835 |
Hollman PC and Katan MB | Absorption, metabolism and health effects of dietary flavonoids in man. | 1997 | Biomed. Pharmacother. | pmid:9436520 |
Collins BM et al. | The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast. | 1997 | Steroids | pmid:9090797 |
Konno C et al. | Morusinol, isoprenoid flavone from Morus root barks. | 1977 | Planta Med. | pmid:905426 |
Harlow GR and Halpert JR | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. | 1997 | J. Biol. Chem. | pmid:9038138 |
Siess MH et al. | Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids. | 1996 | J Toxicol Environ Health | pmid:8968409 |
Canivenc-Lavier MC et al. | Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. | 1996 | Toxicology | pmid:8931757 |
Chaumontet C et al. | Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. | 1996 | Nutr Cancer | pmid:8910908 |
Critchfield JW et al. | Inhibition of HIV activation in latently infected cells by flavonoid compounds. | 1996 | AIDS Res. Hum. Retroviruses | pmid:8825617 |
Karton Y et al. | Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. | 1996 | J. Med. Chem. | pmid:8691424 |
Ebel J and Hahlbrock K | Enzymes of flavone and flavonol-glycoside biosynthesis. Coordinated and selective induction in cell-suspension cultures of Petroselinum hortense. | 1977 | Eur. J. Biochem. | pmid:862617 |
Ji XD et al. | Interactions of flavonoids and other phytochemicals with adenosine receptors. | 1996 | J. Med. Chem. | pmid:8576921 |
Ching LM et al. | Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). | 1994 | Cancer Res. | pmid:8313372 |
Monici M et al. | Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271117 |
Valenti P et al. | Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. | 1993 | Anticancer Drug Des. | pmid:8251042 |
Tamura M et al. | Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain. | 1994 | Jpn. J. Pharmacol. | pmid:7990275 |
Liu H and Wehmeyer KR | Supercritical fluid extraction as a sample preparation technique for the direct isolation of drugs from plasma prior to analysis. | 1994 | J. Chromatogr. B, Biomed. Appl. | pmid:7952070 |
Nijhoff WA et al. | Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone. | 1995 | Carcinogenesis | pmid:7697820 |
Shin W et al. | Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. | 1995 | J. Med. Chem. | pmid:7473560 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VII. Synthesis of 6,8-dimethoxyflavone derivatives and their 13C-NMR (author's transl)]. | 1980 | Yakugaku Zasshi | pmid:7463312 |
Alworth WL et al. | Stimulation of mammalian epoxide hydrase activity by flavones. | 1980 | Xenobiotica | pmid:7415221 |
Rossi M et al. | Molecular structures of 5,6- and 7,8-benzoflavones, inhibitors of aryl hydrocarbon hydroxylase. | 1980 | Cancer Res. | pmid:7388828 |
Udupa SR and Chadha MS | Microbiological transformations of flavonoids: Part V--Transformation of flavone. | 1978 | Indian J. Biochem. Biophys. | pmid:738753 |
Viswanathan T and Alworth WL | Effects of 1-arylpyrroles and naphthoflavones upon cytochrome P-450 dependent monooxygenase activities. | 1981 | J. Med. Chem. | pmid:7277387 |
Lasker JM et al. | In vivo activation of zoxazolamine metabolism by flavone. | 1982 | Science | pmid:7089530 |
Okuda J et al. | Inhibition of aldose reductases from rat and bovine lenses by flavonoids. | 1982 | Biochem. Pharmacol. | pmid:6818971 |
Keller G and Leuenberger PM | [Aldose-reductase inhibitors and cataract formation (author's transl)]. | 1980 | Klin Monbl Augenheilkd | pmid:6775130 |
Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Hausen BM et al. | 5,8-dihydroxyflavone (primetin) the contact sensitizer of Primula mistassinica Michaux. | 1983 | Arch. Dermatol. Res. | pmid:6660907 |
Matern U et al. | Further characterization and regulation of malonyl-coenzyme A: flavonoid glucoside malonyltransferases from parsley cell suspension cultures. | 1983 | Arch. Biochem. Biophys. | pmid:6639051 |
Dutta D et al. | Induction of benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: evidences of multiple forms of cytochrome P-450. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6626210 |
Ficarra P et al. | Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. | 1984 | Farmaco Prat | pmid:6542533 |
Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
Ghosh DK et al. | Microsomal benzo(a)pyrene hydroxylase in Aspergillus ochraceus TS: assay and characterization of the enzyme system. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6409103 |
Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
Hildebrandt AG et al. | Studies on the mechanism of stimulation of microsomal H2O2 formation and benzo(a)pyrene hydroxylation by substrates and flavone. | 1981 | Adv. Exp. Med. Biol. | pmid:6283811 |
Huang MT et al. | Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. | 1981 | J. Biol. Chem. | pmid:6270135 |
He ZY | [Preliminary study on the treatment of coronary heart disease with total flavone of Caulis piperis Futokadsurae]. | 1983 | Zhong Xi Yi Jie He Za Zhi | pmid:6227404 |
Agosin M | The aerobic metabolism of metronidazole by Trypanosoma cruzi epimastigotes. | 1983 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:6138198 |
Teubert H et al. | [Flavonols and flavones of vegetables. VIII. Flavones of carrot leaves (author's transl)]. | 1977 | Z Lebensm Unters Forsch | pmid:595898 |
Narain NK | Flavonoids from Vernonia fasciculata Michx. Isolation of genkwanin and a new flavone disaccharide, fasciculatin. | 1977 | J. Chem. Soc. Perkin Trans. I | pmid:559004 |
Iinuma M and Matsuura S | [Synthetic studies of the flavone derivatives. VI. The synthesis of skullcapflavone I, II and related flavones (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:536899 |
Zhang BH et al. | [The effects of the total flavone of Ku-shen on cardiac arrhythmias (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:532643 |
Hänsel R and Ohlendorf D | [A new flavone from Achyrocline satureoides unsubstituted in ring B]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5290613 |
Brieskorn CH and Biechele W | [Flavones from Salvia officinalis L. 22. Components of Salvia off. L]. | 1971 | Arch Pharm Ber Dtsch Pharm Ges | pmid:5284536 |
Cutroneo KR et al. | Induction of benzpyrene hydroxylase by flavone and its derivatives in fetal rat liver explants. | 1972 | Biochem. Pharmacol. | pmid:5064734 |
Imre S | [Additional anthraquinone and flavone compounds from the leaves of Digitalis viridiflora. 3. Flavone and anthraquinone dyes of digitalis species]. | 1972 | Planta Med. | pmid:5047478 |
Takido M et al. | [On the revised structure of skullcapflavone I, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon) (author's transl)]. | 1979 | Yakugaku Zasshi | pmid:480145 |
Buset H and Scheline RR | Identification of urinary metabolites of flavanone in the rat. | 1979 | Biomed. Mass Spectrom. | pmid:476285 |
Matsuura S and Kunii T | [Synthetic studies of the flavone derivatives. II. Synthesis of cirsimaritin (author's transl)]. | 1974 | Yakugaku Zasshi | pmid:4473114 |
Dorneanu V et al. | [Determination of flavone derivatives. I. Quantitative determination of condensation products of rutin with epsiolon-aminocaproic acid]. | 1974 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:4453725 |
Cavé A et al. | [Pachypodol (5,4'-dihydroxy 3,7,3'-trimethoxy flavone or 3,7,3'-quercetol trimethylether), a new flavonoid isolated from Pachypodanthium confine Engler and Diels (annonaceae)]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4201538 |
Friedman FK et al. | Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. | 1985 | Pharmacology | pmid:4059325 |
Sziklai I and Ribári O | The effect of flavone treatment on human otosclerotic ossicle organ cultures. | 1985 | Arch Otorhinolaryngol | pmid:4038152 |
Alworth WL and Slaga TJ | Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. | 1985 | Carcinogenesis | pmid:3921269 |
Hii CS and Howell SL | Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. | 1985 | J. Endocrinol. | pmid:3900267 |
Bibby MC et al. | Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). | 1987 | Br. J. Cancer | pmid:3814485 |
Zaharko DS et al. | Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. | 1986 | Cancer Treat Rep | pmid:3791254 |
Double JA et al. | Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. | 1986 | Br. J. Cancer | pmid:3778803 |
Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
Kerr DJ et al. | Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). | 1986 | Cancer Res. | pmid:3698028 |
Capolongo LS et al. | Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. | 1987 | Eur J Cancer Clin Oncol | pmid:3678316 |
Kerr DJ et al. | Phase I and pharmacokinetic study of flavone acetic acid. | 1987 | Cancer Res. | pmid:3677106 |
Abdalla SS and Abu Zarga MH | Effects of cirsimaritin, a flavone isolated from Artemisia judaica, on isolated guinea-pig ileum. | 1987 | Planta Med. | pmid:3671552 |
Ching LM and Baguley BC | Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). | 1987 | Eur J Cancer Clin Oncol | pmid:3665989 |
Smith GP et al. | Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. | 1987 | Eur J Cancer Clin Oncol | pmid:3653213 |
Schroyens WA et al. | In vitro chemosensitivity testing of flavone acetic acid (LM975; NSC 347512) and its diethylaminoethyl ester derivative (LM985; NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653209 |
Dodion PF et al. | Clinical and pharmacokinetic phase I trial with the diethylaminoester of flavone acetic acid (LM985, NSC 293015). | 1987 | Eur J Cancer Clin Oncol | pmid:3653200 |
Gao F et al. | Sesquiterpene lactones and flavonoids from Helianthus species. | 1987 Jan-Feb | J. Nat. Prod. | pmid:3598595 |
Ruffmann R and Sartani A | Flavoxate, a drug with smooth muscle relaxing activity. | 1987 | Drugs Exp Clin Res | pmid:3595445 |
Drewinko B and Yang LY | The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro. | 1986 | Invest New Drugs | pmid:3583640 |
Corbett TH et al. | Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. | 1986 | Invest New Drugs | pmid:3546183 |
O'Dwyer PJ et al. | Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent. | 1987 | Cancer Chemother. Pharmacol. | pmid:3545524 |
Vernet A and Siess MH | Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes. | 1986 | Food Chem. Toxicol. | pmid:3491024 |
Dodion P et al. | Sensitivity of normal human bone marrow myeloid progenitor cells to anthracycline, cisplatin, anthracene and flavone acetic acid derivatives, and its relevance for the prediction of human plasma concentrations of anticancer drugs. | 1987 | Eur J Cancer Clin Oncol | pmid:3436354 |
Bissery MC et al. | Flavone acetic acid (NSC 347512)-induced DNA damage in Glasgow osteogenic sarcoma in vivo. | 1988 | Cancer Res. | pmid:3422592 |
Oberpichler H et al. | Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. | 1988 | Pharmacol Res Commun | pmid:3420139 |
Hornung RL et al. | Immunomodulation of natural killer cell activity by flavone acetic acid: occurrence via induction of interferon alpha/beta. | 1988 | J. Natl. Cancer Inst. | pmid:3418728 |
Abdalla S et al. | Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated guinea-pig smooth muscle. | 1988 | Gen. Pharmacol. | pmid:3410278 |
Gouyette A et al. | Flavone acetic acid: a nonlinear pharmacokinetic model. | 1988 | Cancer Chemother. Pharmacol. | pmid:3409441 |
Evelhoch JL et al. | Flavone acetic acid (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. | 1988 | Cancer Res. | pmid:3409216 |
Damia G et al. | Dose-dependent pharmacokinetics of flavone acetic acid in mice. | 1988 | Cancer Chemother. Pharmacol. | pmid:3396145 |
Giavazzi R et al. | Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. | 1988 | Br. J. Cancer | pmid:3355765 |
Finlay GJ et al. | Effect of flavone acetic acid on Lewis lung carcinoma: evidence for an indirect effect. | 1988 | J. Natl. Cancer Inst. | pmid:3351960 |
Fisher RF et al. | Specific binding of proteins from Rhizobium meliloti cell-free extracts containing NodD to DNA sequences upstream of inducible nodulation genes. | 1988 | Genes Dev. | pmid:3288541 |
Wiltrout RH et al. | Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer. | 1988 | J. Immunol. | pmid:3258894 |
Abbiati GA et al. | Receptor binding studies of the flavone, REC 15/2053, and other bladder spasmolytics. | 1988 | Pharm. Res. | pmid:3247311 |
Hayashi T et al. | A cytotoxic flavone from Scoparia dulcis L. | 1988 | Chem. Pharm. Bull. | pmid:3246045 |
Robbins RC | Flavones in citrus exhibit antiadhesive action on platelets. | 1988 | Int J Vitam Nutr Res | pmid:3243696 |
Rabinovitz M | The structure of flavone-8-acetic acid, a chemotherapeutic agent, and its application to drug design. | 1988 | J. Enzym. Inhib. | pmid:3236069 |
Armitage JP et al. | Comparison of the chemotactic behaviour of Rhizobium leguminosarum with and without the nodulation plasmid. | 1988 | Mol. Microbiol. | pmid:3210967 |
Chen JC et al. | [Anti-arrhythmic action of 4'-methyl-7-([2-hydroxy-3-(beta-propinamidoethyl)amino]propoxy) flavone hydrochloride (SIPI-644)]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3188948 |
Gachályi A et al. | Mobilization of 85Sr by flavone derivatives (morin and ipriflavone) in normal and pregnant rats. | 1988 | Radiobiol Radiother (Berl) | pmid:3186955 |
Ching LM and Baguley BC | Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512). | 1988 | Eur J Cancer Clin Oncol | pmid:3181272 |