FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kurian G et al. | A Novel Approach for Oral Delivery of Insulin via Desmodium gangeticum Aqueous Root Extract. | 2010 | J Young Pharm | pmid:21264119 |
Ghasemzadeh A et al. | Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. | 2010 | Int J Mol Sci | pmid:21151455 |
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Wang XH et al. | Screen of micro-organisms for inducing the production of dragon's blood by leaf of Dracaena cochinchinensis. | 2010 | Lett. Appl. Microbiol. | pmid:20860774 |
Guo W et al. | Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. | 2010 | Eur. J. Pharmacol. | pmid:20854805 |
Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
Luo H et al. | Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. | 2010 | BMC Plant Biol. | pmid:20854695 |
Chen CC et al. | Calcium- and phosphatidylinositol 3-kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin. | 2010 | Life Sci. | pmid:21034748 |
Zou GA et al. | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. | 2010 | Molecules | pmid:20335965 |
Chen EP et al. | A mechanism-based mathematical model of aryl hydrocarbon receptor-mediated CYP1A induction in rats using beta-naphthoflavone as a tool compound. | 2010 | Drug Metab. Dispos. | pmid:20843940 |
Ragab FA et al. | Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives. | 2010 | Chem. Pharm. Bull. | pmid:20823592 |
Stark JL et al. | Solution structure and function of YndB, an AHSA1 protein from Bacillus subtilis. | 2010 | Proteins | pmid:20818668 |
Chung KS et al. | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. | 2010 | Mol Nutr Food Res | pmid:20397191 |
Schubert M et al. | Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata. | 2010 | Planta | pmid:19915863 |
Goodger JQ et al. | Isolation of intact sub-dermal secretory cavities from Eucalyptus. | 2010 | Plant Methods | pmid:20807444 |
Zhang A et al. | Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. | 2010 | J Ovarian Res | pmid:20723224 |
Du Y et al. | CYP93G2 is a flavanone 2-hydroxylase required for C-glycosylflavone biosynthesis in rice. | 2010 | Plant Physiol. | pmid:20647377 |
Gassmann K et al. | Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. | 2010 | Environ. Health Perspect. | pmid:20570779 |
Du Y et al. | Identification of flavone phytoalexins and a pathogen-inducible flavone synthase II gene (SbFNSII) in sorghum. | 2010 | J. Exp. Bot. | pmid:20007684 |
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Akhtar TA et al. | Photosynthetic redox imbalance influences flavonoid biosynthesis in Lemna gibba. | 2010 | Plant Cell Environ. | pmid:20199616 |
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Wera M et al. | 2-(4-Fluoro-phen-yl)-3-hy-droxy-4H-chromen-4-one. | 2010 | Acta Crystallogr Sect E Struct Rep Online | pmid:21589426 |
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Mays JR et al. | The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. | 2010 | Bioorg. Med. Chem. | pmid:19932969 |
Ono M et al. | 99mTc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20797860 |
Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
Xu H et al. | Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis. | 2010 | Bioresour. Technol. | pmid:20708926 |
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Alam MS and Lee DU | Facile synthesis and antibacterial activity of naturally occurring 5-methoxyfuroflavone. | 2010 | Chem. Pharm. Bull. | pmid:21139271 |
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Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
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Zhang Y et al. | Reproducibility and relative validity of a food frequency questionnaire to assess intake of dietary flavonol and flavone in Chinese university campus population. | 2010 | Nutr Res | pmid:20851305 |
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Tian Y et al. | Anti-HBV active flavone glucosides from Euphorbia humifusa Willd. | 2010 | Fitoterapia | pmid:20450964 |
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Kosmider B et al. | Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II). | 2010 | Arzneimittelforschung | pmid:20422947 |
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