FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takada Y and Aggarwal BB | Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | 2004 | J. Biol. Chem. | pmid:14630924 |
| Uyemura SA et al. | Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. | 2004 | J. Biol. Chem. | pmid:14561763 |
| Galietta LJ et al. | Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. | 2001 | J. Biol. Chem. | pmid:11262417 |
| Lotito SB and Frei B | Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. | 2006 | J. Biol. Chem. | pmid:16987811 |
| Huang MT et al. | Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes. | 1981 | J. Biol. Chem. | pmid:6270135 |
| Harlow GR and Halpert JR | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. | 1997 | J. Biol. Chem. | pmid:9038138 |
| Skizim NJ et al. | Metabolic pathways for photobiological hydrogen production by nitrogenase- and hydrogenase-containing unicellular cyanobacteria Cyanothece. | 2012 | J. Biol. Chem. | pmid:22128188 |
| Guo AJ et al. | Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | 2011 | J. Biol. Chem. | pmid:21652696 |
| Martins VP et al. | Mitochondrial function in the yeast form of the pathogenic fungus Paracoccidioides brasiliensis. | 2008 | J. Bioenerg. Biomembr. | pmid:18797987 |
| Wei Z et al. | Cardamonin protects septic mice from acute lung injury by preventing endothelial barrier dysfunction. | 2012 | J. Biochem. Mol. Toxicol. | pmid:22696397 |
| Aslan E and Adem S | In vitro effects of some flavones on human pyruvate kinase isoenzyme M2. | 2015 | J. Biochem. Mol. Toxicol. | pmid:25388478 |
| Li BH et al. | Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | 2005 | J. Biochem. | pmid:16428296 |
| Kasai N et al. | Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium. | 2010 | J. Biochem. | pmid:19819902 |
| Perry JD et al. | Evaluation of novel chromogenic substrates for the detection of bacterial beta-glucosidase. | 2007 | J. Appl. Microbiol. | pmid:17241346 |
| Novy P et al. | In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. | 2011 | J. Antimicrob. Chemother. | pmid:21421582 |
| Zhang J et al. | Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15694764 |
| Fabre N et al. | Determination of flavone, flavonol, and flavanone aglycones by negative ion liquid chromatography electrospray ion trap mass spectrometry. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11401161 |
| Ma YL et al. | Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation. | 2000 | J. Am. Soc. Mass Spectrom. | pmid:10689666 |
| Pikulski M et al. | Tunable transition metal-ligand complexation for enhanced elucidation of flavonoid diglycosides by electrospray ionization mass spectrometry. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17112735 |
| Caddick S et al. | Synthetic ligands for apo-neocarzinostatin. | 2006 | J. Am. Chem. Soc. | pmid:16568976 |
| Klier L et al. | Lewis acid-triggered selective zincation of chromones, quinolones, and thiochromones: application to the preparation of natural flavones and isoflavones. | 2012 | J. Am. Chem. Soc. | pmid:22860983 |
| Gauci AJ et al. | Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates. | 2011 | J. Alzheimers Dis. | pmid:21891862 |
| Weng Z et al. | The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. | 2015 | J. Allergy Clin. Immunol. | pmid:25498791 |
| Rayyan S et al. | Flavone C-glycosides from seeds of fenugreek, Trigonella foenum-graecum L. | 2010 | J. Agric. Food Chem. | pmid:20486688 |
| Fiorentino A et al. | Identification and assessment of antioxidant capacity of phytochemicals from kiwi fruits. | 2009 | J. Agric. Food Chem. | pmid:19358604 |
| Jeong SH et al. | Tyrosinase inhibitory polyphenols from roots of Morus lhou. | 2009 | J. Agric. Food Chem. | pmid:19166303 |
| Gobbo-Neto L and Lopes NP | Online identification of chlorogenic acids, sesquiterpene lactones, and flavonoids in the Brazilian arnica Lychnophora ericoides Mart. (Asteraceae) leaves by HPLC-DAD-MS and HPLC-DAD-MS/MS and a validated HPLC-DAD method for their simultaneous analysis. | 2008 | J. Agric. Food Chem. | pmid:18237124 |
| Morimoto M et al. | Insect antifeedant activity of flavones and chromones against Spodoptera litura. | 2003 | J. Agric. Food Chem. | pmid:12517100 |
| Yang L et al. | Purification and characterization of an isoflavone-conjugates-hydrolyzing beta-glucosidase from endophytic bacterium. | 2004 | J. Agric. Food Chem. | pmid:15053533 |
| Kim H et al. | Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. | 2005 | J. Agric. Food Chem. | pmid:16248550 |
| Xiao J et al. | Noncovalent interaction of dietary polyphenols with common human plasma proteins. | 2011 | J. Agric. Food Chem. | pmid:21863815 |
| Appeldoorn MM et al. | Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. | 2009 | J. Agric. Food Chem. | pmid:19722703 |
| Caristi C et al. | Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. | 2003 | J. Agric. Food Chem. | pmid:12769519 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Nørbaek R et al. | Flavone C-glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments. | 2003 | J. Agric. Food Chem. | pmid:12537462 |
| Manthey JA and Guthrie N | Antiproliferative activities of citrus flavonoids against six human cancer cell lines. | 2002 | J. Agric. Food Chem. | pmid:12358447 |
| Xu B and Chang SK | Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. | 2010 | J. Agric. Food Chem. | pmid:20058926 |
| MarÃn FR and Del RÃo JA | Selection of hybrids and edible citrus species with a high content in the diosmin functional compound. Modulating effect of plant growth regulators on contents. | 2001 | J. Agric. Food Chem. | pmid:11453775 |
| Bandaruk Y et al. | Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. | 2012 | J. Agric. Food Chem. | pmid:23009399 |
| Chang TL | Inhibitory effect of flavonoids on 26S proteasome activity. | 2009 | J. Agric. Food Chem. | pmid:19795881 |
| Rossi A et al. | Inhibition of inducible nitric oxide synthase expression by an acetonic extract from Feijoa sellowiana Berg. fruits. | 2007 | J. Agric. Food Chem. | pmid:17550270 |
| Kim S et al. | Promotion of Glucose Uptake in C2C12 Myotubes by Cereal Flavone Tricin and Its Underlying Molecular Mechanism. | 2017 | J. Agric. Food Chem. | pmid:28474889 |
| Kwon HM et al. | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. | 2005 | J. Agric. Food Chem. | pmid:15969490 |
| Yang JM et al. | Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. | 2010 | J. Agric. Food Chem. | pmid:20734985 |
| Lin YC et al. | Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). | 2010 | J. Agric. Food Chem. | pmid:20698539 |
| Ho YC et al. | Re-examination of chromogenic quantitative assays for determining flavonoid content. | 2012 | J. Agric. Food Chem. | pmid:22352692 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Zbidah M et al. | Apigenin-induced suicidal erythrocyte death. | 2012 | J. Agric. Food Chem. | pmid:22132906 |
| Lee SE et al. | Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. | 2001 | J. Agric. Food Chem. | pmid:11714299 |
| Echeverry C et al. | Pretreatment with natural flavones and neuronal cell survival after oxidative stress: a structure-activity relationship study. | 2010 | J. Agric. Food Chem. | pmid:20095615 |