FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ching LM and Baguley BC | Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). | 1989 | Eur J Cancer Clin Oncol | pmid:2591444 |
Chabot GG et al. | Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. | 1989 | Cancer Chemother. Pharmacol. | pmid:2597279 |
Ching LM and Baguley BC | Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2597283 |
Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
Lewis CR et al. | Autonomic neuropathy following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2703010 |
Nagai T et al. | Inhibition of mouse liver sialidase by plant flavonoids. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775264 |
Sun JR and Brown JM | Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. | 1989 | Cancer Res. | pmid:2790784 |
Cassidy J et al. | Could interspecies differences in the protein binding of flavone acetic acid contribute to the failure to predict lack of efficacy in patients? | 1989 | Cancer Chemother. Pharmacol. | pmid:2713962 |
Lonchampt M et al. | Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. | 1989 | Arzneimittelforschung | pmid:2818676 |
Lee DW and Park KH | Testosterone metabolism by microsomal cytochrome P-450 in liver of rats treated with some inducers. | 1989 | Int. J. Biochem. | pmid:2502444 |