FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Chen IL et al. | Synthesis and antiproliferative evaluation of amide-containing flavone and isoflavone derivatives. | 2008 | Bioorg. Med. Chem. | pmid:18662883 |
Golub AG et al. | Discovery and characterization of synthetic 4'-hydroxyflavones-New CK2 inhibitors from flavone family. | 2013 | Bioorg. Med. Chem. | pmid:24011954 |
Springsteel MF et al. | Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. | 2003 | Bioorg. Med. Chem. | pmid:12927873 |
Ullah Mughal E et al. | Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones. | 2006 | Bioorg. Med. Chem. | pmid:16603364 |
Dong X et al. | Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents. | 2008 | Bioorg. Med. Chem. | pmid:18678502 |
Greeff J et al. | Antioxidant properties of 4-quinolones and structurally related flavones. | 2012 | Bioorg. Med. Chem. | pmid:22197671 |
Marder M et al. | Molecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complex. | 2001 | Bioorg. Med. Chem. | pmid:11249125 |
Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
Lewin G et al. | Influence of the skeleton on the cytotoxicity of flavonoids. | 2012 | Bioorg. Med. Chem. | pmid:22257529 |
Liu H et al. | New synthetic flavone derivatives induce apoptosis of hepatocarcinoma cells. | 2010 | Bioorg. Med. Chem. | pmid:20674374 |