FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
| Lee MH et al. | Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells. | 2006 | Phytochemistry | pmid:16782143 |
| Carrara M et al. | Mono- or di-fluorinated analogues of flavone-8-acetic acid: synthesis and in vitro biological activity. | 2005 Mar-Apr | Anticancer Res. | pmid:15868960 |
| Kanho H et al. | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. | 2005 | Chem. Pharm. Bull. | pmid:15802832 |
| Zhang J et al. | Threshold dissociation and molecular modeling of transition metal complexes of flavonoids. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15694764 |
| Madan V et al. | Requirement of the vesicular system for membrane permeabilization by Sindbis virus. | 2005 | Virology | pmid:15661162 |
| Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
| Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
| Sasaki K et al. | Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. | 2005 | J. Pharm. Pharmacol. | pmid:15831206 |
| Zheng W et al. | [Study on extraction of zhuyun 3# by supercritical CO2]. | 2005 | Zhong Yao Cai | pmid:16104514 |
| Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
| Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
| Wang TC et al. | Synthesis, and cytotoxic and antiplatelet activities of oxime- and methyloxime-containing flavone, isoflavone, and xanthone derivatives. | 2005 | Chem. Biodivers. | pmid:17191978 |
| Cappelli C et al. | Computational study of conformational and chiroptical properties of (2R,3S,4R)-(+)-3,3',4,4',7-flavanpentol. | 2005 | Chirality | pmid:16196026 |
| Martens S and Mithöfer A | Flavones and flavone synthases. | 2005 | Phytochemistry | pmid:16137727 |
| Cong Y et al. | A new flavonoside from Leonurus heterophyllus. | 2005 | J Asian Nat Prod Res | pmid:15621638 |
| Singh RP et al. | Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. | 2005 | Carcinogenesis | pmid:15637089 |
| Yang Y et al. | Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration. | 2005 | J. Inherit. Metab. Dis. | pmid:16435199 |
| Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
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| Kovacic P | Fundamental, electron transfer mechanism by pyrylium-type ions for the anticancer drugs 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA). | 2005 | Curr Med Chem Anticancer Agents | pmid:16178775 |
| Ozbey S et al. | Antibacterial 4-amino-N-(5-methylisoxazol-3-yl)-N-[(4-oxo-2-phenyl-4H-1-benzopyran-6-yl)methyl]benzenesulfonamide. | 2005 | Acta Crystallogr C | pmid:16143780 |
| Huong DT et al. | A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). | 2005 | Pharmazie | pmid:16124409 |
| Woodman OL et al. | Vasorelaxant and antioxidant activity of flavonols and flavones: structure-activity relationships. | 2005 | J. Cardiovasc. Pharmacol. | pmid:16116335 |
| Shiono M et al. | Phytochemistry: structure of the blue cornflower pigment. | 2005 | Nature | pmid:16094358 |
| Bankova V | Chemical diversity of propolis and the problem of standardization. | 2005 | J Ethnopharmacol | pmid:15993016 |
| Machha A and Mustafa MR | Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. | 2005 | J. Cardiovasc. Pharmacol. | pmid:15965352 |
| Göker H et al. | Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles. | 2005 | Bioorg. Med. Chem. | pmid:15698788 |
| Schütz K et al. | Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15593267 |
| Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
| Furuya H et al. | Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant. | 2005 | Biochem. Pharmacol. | pmid:15652241 |
| Cai H et al. | The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. | 2005 | Mol. Cancer Ther. | pmid:16170019 |
| Kwon HM et al. | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. | 2005 | J. Agric. Food Chem. | pmid:15969490 |
| Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
| Xiao R et al. | Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis. | 2005 | Mol. Cancer | pmid:15644144 |
| Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
| Garritano S et al. | Assessment of estrogenic activity of flavonoids from Mediterranean plants using an in vitro short-term test. | 2005 | Phytomedicine | pmid:15693722 |
| Kachlicki P et al. | Profiling isoflavone conjugates in root extracts of lupine species with LC/ESI/MSn systems. | 2005 | J Mass Spectrom | pmid:15971291 |
| Girish KS and Kemparaju K | Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. | 2005 | Biochemistry Mosc. | pmid:16212553 |
| Ahmed-Belkacem A et al. | Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2. | 2005 | Cancer Res. | pmid:15930306 |
| Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
| UydeÅŸ-DoÄŸan BS et al. | The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. | 2005 | Vascul. Pharmacol. | pmid:16169284 |
| Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
| Chi YS and Kim HP | Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15589400 |
| Lu H et al. | Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. | 2005 | J. Med. Chem. | pmid:15689157 |
| Capodice JL et al. | Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. | 2005 | Evid Based Complement Alternat Med | pmid:16322807 |
| Watanabe J et al. | Coumarin and flavone derivatives from estragon and thyme as inhibitors of chemical mediator release from RBL-2H3 Cells. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15665459 |
| Xie F et al. | The osteoprotective effect of Herba epimedii (HEP) extract in vivo and in vitro. | 2005 | Evid Based Complement Alternat Med | pmid:16136213 |