FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fernández SP et al. | Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. | 2005 | Eur. J. Pharmacol. | pmid:15840404 |
| Jahaniani F et al. | Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. | 2005 | Phytochemistry | pmid:15949825 |
| Rayyan S et al. | Flavone C-glycosides from leaves of Oxalis triangularis. | 2005 | J. Agric. Food Chem. | pmid:16366694 |
| Cai H et al. | Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection. | 2005 | Biomed. Chromatogr. | pmid:15828058 |
| Wenzel U et al. | Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. | 2005 | Int. J. Cancer | pmid:15800915 |
| Sasaki K et al. | Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. | 2005 | J. Pharm. Pharmacol. | pmid:15831206 |
| Zheng W et al. | [Study on extraction of zhuyun 3# by supercritical CO2]. | 2005 | Zhong Yao Cai | pmid:16104514 |
| Griffin RJ et al. | Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | 2005 | J. Med. Chem. | pmid:15658870 |
| Park H et al. | Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives. | 2005 | Eur J Med Chem | pmid:15963606 |
| Horvath CR et al. | Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. | 2005 | J Chromatogr A | pmid:15679157 |
| Wenzel U et al. | Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. | 2005 | Cell. Mol. Life Sci. | pmid:16314920 |
| Yang Y et al. | Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration. | 2005 | J. Inherit. Metab. Dis. | pmid:16435199 |
| Boyer J et al. | In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. | 2005 | Nutr J | pmid:15644141 |
| Li BH et al. | Structure-activity relationship of polyphenols that inhibit fatty acid synthase. | 2005 | J. Biochem. | pmid:16428296 |
| Rothwell JA et al. | Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. | 2005 | J. Agric. Food Chem. | pmid:15913295 |
| Iori F et al. | Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes. | 2005 | Bioorg. Med. Chem. | pmid:15914008 |
| Han Y | Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritic inflammation. | 2005 | Int. Immunopharmacol. | pmid:15829420 |
| Sawada Y and Ayabe S | Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15809082 |
| Ko WC et al. | Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. | 2005 | Planta Med. | pmid:15931576 |
| Budzianowski J et al. | Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. | 2005 | Phytochemistry | pmid:15896373 |
| Wenzel U et al. | Activation of mitochondrial lactate uptake by flavone induces apoptosis in human colon cancer cells. | 2005 | J. Cell. Physiol. | pmid:15452831 |
| Åania-Pietrzak B et al. | Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. | 2005 | Life Sci. | pmid:15916776 |
| Jeyabal PV et al. | Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats. | 2005 | Mol. Carcinog. | pmid:15924350 |
| Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
| McMullen MD et al. | Salmon silk genes contribute to the elucidation of the flavone pathway in maize (Zea mays L.). | 2004 May-Jun | J. Hered. | pmid:15220389 |
| Ching LM et al. | Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. | 2004 | Br. J. Cancer | pmid:14970872 |
| Takada Y and Aggarwal BB | Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. | 2004 | J. Biol. Chem. | pmid:14630924 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Uyemura SA et al. | Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. | 2004 | J. Biol. Chem. | pmid:14561763 |
| Tudella VG et al. | In situ evidence of an alternative oxidase and an uncoupling protein in the respiratory chain of Aspergillus fumigatus. | 2004 | Int. J. Biochem. Cell Biol. | pmid:14592541 |
| Atkinson C et al. | Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. | 2004 | Breast Cancer Res. | pmid:15084240 |
| Wu W et al. | Studies on the flavones using liquid chromatography-electrospray ionization tandem mass spectrometry. | 2004 | J Chromatogr A | pmid:15460251 |
| Quiney C et al. | Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells. | 2004 | Leuk. Res. | pmid:15203283 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Leung LK et al. | Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction. | 2004 | Br. J. Nutr. | pmid:15182386 |
| Gao H et al. | Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981300 |
| Kagawa H et al. | Oxidation and rearrangements of flavanones by mammalian cytochrome P450. | 2004 | Xenobiotica | pmid:15742975 |
| Kim YW et al. | Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones. | 2004 | J. Med. Chem. | pmid:15267241 |
| Kong X et al. | Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken. | 2004 | Int. Immunopharmacol. | pmid:15233143 |
| O'Leary KA et al. | Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. | 2004 | Mutat. Res. | pmid:15225597 |
| Hirvonen T et al. | Flavonol and flavone intake and the risk of intermittent claudication in male smokers. | 2004 | Eur. J. Epidemiol. | pmid:15180100 |
| Goppel M and Franz G | Stability control of senna leaves and senna extracts. | 2004 | Planta Med. | pmid:15124088 |
| Cho H et al. | Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. | 2004 | Pharmacol. Res. | pmid:14597150 |
| Son D et al. | Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. | 2004 | Eur. J. Pharmacol. | pmid:15189769 |
| van Duursen MB et al. | Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage. | 2004 | Toxicol. Sci. | pmid:15254334 |
| Wenzel U and Daniel H | Early and late apoptosis events in human transformed and non-transformed colonocytes are independent on intracellular acidification. | 2004 | Cell. Physiol. Biochem. | pmid:14976408 |
| Wang QE et al. | Isolation and purification of inflacoumarin A and licochalcone A from licorice by high-speed counter-current chromatography. | 2004 | J Chromatogr A | pmid:15453418 |
| Herzog A et al. | Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. | 2004 | Int. J. Cancer | pmid:14750173 |
| Tammela P et al. | Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. | 2004 | Arch. Biochem. Biophys. | pmid:15111127 |
| Wang SP and Huang KJ | Determination of flavonoids by high-performance liquid chromatography and capillary electrophoresis. | 2004 | J Chromatogr A | pmid:15065805 |