FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Paulin JJ et al. | Ultrastructural modifications during the metabolism of metronidazole by Trypanosoma cruzi. | 1983 | J. Submicrosc. Cytol. | pmid:6361276 |
Tóth L et al. | [Analysis of flavone derivatives by polyamide layer chromatography]. | 1984 | Acta Pharm Hung | pmid:6711313 |
Elliger CA et al. | Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships. | 1984 | Mutat. Res. | pmid:6363915 |
Ficarra P et al. | Analysis of 2-phenyl-chromon derivatives and chlorogenic acid. II. High-performance thin layer chromatography and high-performance liquid chromatography in flowers, leaves and buds extractives of Crataegus oxyacantha L. | 1984 | Farmaco Prat | pmid:6542533 |
Nose K | Inhibition by flavonoids of RNA synthesis in permeable WI-38 cells and of transcription by RNA polymerase II. | 1984 | Biochem. Pharmacol. | pmid:6508836 |
Barberán FA et al. | Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella. | 1985 | Planta Med. | pmid:17342612 |
Li XF | [Effects of flavone II of Piper wallichii on the isolated rabbit heart]. | 1985 | Zhong Yao Tong Bao | pmid:2934172 |
Hii CS and Howell SL | Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. | 1985 | J. Endocrinol. | pmid:3900267 |
Alworth WL and Slaga TJ | Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyldibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice. | 1985 | Carcinogenesis | pmid:3921269 |
Sziklai I and Ribári O | The effect of flavone treatment on human otosclerotic ossicle organ cultures. | 1985 | Arch Otorhinolaryngol | pmid:4038152 |
Friedman FK et al. | Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. | 1985 | Pharmacology | pmid:4059325 |
Saxena M et al. | A New Flavone from Sapium insigne. | 1986 | Planta Med. | pmid:17345426 |
Jiménez MJ et al. | Anti-Inflammatory Activity of a Flavone from Sideritis leucantha. | 1986 | Planta Med. | pmid:17345496 |
Larson RL and Bussard JB | Microsomal flavonoid 3'-monooxygenase from maize seedlings. | 1986 | Plant Physiol. | pmid:16664648 |
Double JA et al. | Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. | 1986 | Br. J. Cancer | pmid:3778803 |
Kerr DJ et al. | Phase I and pharmacokinetic study of LM985 (flavone acetic acid ester). | 1986 | Cancer Res. | pmid:3698028 |
Zaharko DS et al. | Therapeutic and pharmacokinetic relationships of flavone acetic acid: an agent with activity against solid tumors. | 1986 | Cancer Treat Rep | pmid:3791254 |
Plowman J et al. | Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. | 1986 | Cancer Treat Rep | pmid:3708611 |
Drewinko B and Yang LY | The activity of flavone acetic acid (NSC 347512) on human colon cancer cells in vitro. | 1986 | Invest New Drugs | pmid:3583640 |
Corbett TH et al. | Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. | 1986 | Invest New Drugs | pmid:3546183 |