FLAVONE
FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
Cross Reference
Introduction
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with FLAVONE?
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with FLAVONE
PubChem Associated disorders and diseases
What pathways are associated with FLAVONE
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with FLAVONE?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with FLAVONE?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with FLAVONE?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with FLAVONE?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with FLAVONE?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with FLAVONE
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim S et al. | Vascular disrupting agent drug classes differ in effects on the cytoskeleton. | 2012 | PLoS ONE | pmid:22848372 |
| Xin HL et al. | Anti-inflammatory and analgesic activity of total flavone of Cunninghamia lanceolata. | 2012 | Molecules | pmid:22832885 |
| Joshi SC and Mathela CS | Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. | 2012 | Pharmacognosy Res | pmid:22518079 |
| Chantarudee A et al. | Chemical constituents and free radical scavenging activity of corn pollen collected from Apis mellifera hives compared to floral corn pollen at Nan, Thailand. | 2012 | BMC Complement Altern Med | pmid:22513008 |
| Soumyanath A et al. | Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action. | 2012 | Int J Alzheimers Dis | pmid:22506133 |
| Watts SD et al. | A sensitive membrane-targeted biosensor for monitoring changes in intracellular chloride in neuronal processes. | 2012 | PLoS ONE | pmid:22506078 |
| Balboni G et al. | Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22487176 |
| Zandi K et al. | Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. | 2012 | Molecules | pmid:22374315 |
| Kim HG et al. | Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo. | 2012 | Biol. Pharm. Bull. | pmid:22863927 |
| Zielińska D et al. | Evaluation of flavonoid contents and antioxidant capacity of the aerial parts of common and tartary buckwheat plants. | 2012 | Molecules | pmid:22890171 |
| Engelbertz J et al. | Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. | 2012 | J Ethnopharmacol | pmid:22465593 |
| Narwal M et al. | Homogeneous screening assay for human tankyrase. | 2012 | J Biomol Screen | pmid:22357873 |
| Sharma M et al. | Expression of flavonoid 3'-hydroxylase is controlled by P1, the regulator of 3-deoxyflavonoid biosynthesis in maize. | 2012 | BMC Plant Biol. | pmid:23113982 |
| Hammoud L et al. | A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. | 2012 | Nat. Prod. Res. | pmid:21815723 |
| Berim A et al. | A set of regioselective O-methyltransferases gives rise to the complex pattern of methoxylated flavones in sweet basil. | 2012 | Plant Physiol. | pmid:22923679 |
| Seki N et al. | Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways. | 2012 | J. Cell. Biochem. | pmid:22359269 |
| Shi Y et al. | Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. | 2012 | Phytother Res | pmid:22389128 |
| Mijangos MV et al. | Microwave-assisted C-3 selective oxidative radical alkylation of flavones. | 2012 | Org. Biomol. Chem. | pmid:22395456 |
| Kim YW et al. | DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793913 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| El-Alfy TS et al. | A New Flavonoid C-Glycoside from Celtis australis L. and Celtis occidentalis L. Leaves and Potential Antioxidant and Cytotoxic Activities. | 2011 Oct-Dec | Sci Pharm | pmid:22145118 |
| Zhao E and Mu Q | Phytoestrogen biological actions on Mammalian reproductive system and cancer growth. | 2011 Jan-Mar | Sci Pharm | pmid:21617769 |
| Hunyadi A et al. | Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesis of further new cytotoxic protoflavone derivatives. | 2011 | PLoS ONE | pmid:21912610 |
| Vitcheva V et al. | Hepatoprotective effects of saponarin, isolated from Gypsophila trichotoma Wend. on cocaine-induced oxidative stress in rats. | 2011 | Redox Rep. | pmid:21722413 |
| Wang Y et al. | Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds. | 2011 | Evid Based Complement Alternat Med | pmid:19131395 |
| Duan K et al. | LC-MS/MS determination and pharmacokinetic study of five flavone components after solvent extraction/acid hydrolysis in rat plasma after oral administration of Verbena officinalis L. extract. | 2011 | J Ethnopharmacol | pmid:21220003 |
| Lakshmi C et al. | Antibacterial activity of polyphenols of garcinia indica. | 2011 | Indian J Pharm Sci | pmid:22707838 |
| Sancho MI et al. | Spectroscopic study of solvent effects on the electronic absorption spectra of flavone and 7-hydroxyflavone in neat and binary solvent mixtures. | 2011 | Int J Mol Sci | pmid:22272110 |
| Kothandan G et al. | Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. | 2011 | Eur J Med Chem | pmid:21723648 |
| Ibrahim MH et al. | Effects of nitrogen fertilization on synthesis of primary and secondary metabolites in three varieties of Kacip Fatimah (Labisia pumila Blume). | 2011 | Int J Mol Sci | pmid:21954355 |
| Vila-Real H et al. | Enzymatic Synthesis of the Flavone Glucosides, Prunin and Isoquercetin, and the Aglycones, Naringenin and Quercetin, with Selective α-L-Rhamnosidase and β-D-Glucosidase Activities of Naringinase. | 2011 | Enzyme Res | pmid:21941631 |
| Bhavsar AS et al. | A review on recent advances in dry eye: Pathogenesis and management. | 2011 | Oman J Ophthalmol | pmid:21897618 |
| Tahanian E et al. | Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. | 2011 | Drug Des Devel Ther | pmid:21625419 |
| Subbarao PG and Ashok P | Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. | 2011 | J Pharm Bioallied Sci | pmid:21687351 |
| Gasiorowski K et al. | Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? | 2011 | CNS Neurol Disord Drug Targets | pmid:21222632 |
| Quintão NL et al. | Aleurites moluccana (L.) Willd. Leaves: Mechanical Antinociceptive Properties of a Standardized Dried Extract and Its Chemical Markers. | 2011 | Evid Based Complement Alternat Med | pmid:21660087 |
| Guo AJ et al. | Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. | 2011 | J. Biol. Chem. | pmid:21652696 |
| Nerurkar PV et al. | Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. | 2011 | J Neuroinflammation | pmid:21639917 |
| Xia EQ et al. | Microwave-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. | 2011 | Int J Mol Sci | pmid:21954361 |
| Lewin G et al. | Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk. | 2011 | Bioorg. Med. Chem. | pmid:21146994 |
| Szliszka E et al. | Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells. | 2011 | Evid Based Complement Alternat Med | pmid:19892808 |
| Jiang DP et al. | Effects of scutellarin on MUC5AC mucin production induced by human neutrophil elastase or interleukin 13 on airway epithelial cells. | 2011 | J. Korean Med. Sci. | pmid:21655064 |
| Wei H et al. | Neuropective constituents from the rhizomes of Abacopteris penangiana. | 2011 | J Asian Nat Prod Res | pmid:21751838 |
| Xue L et al. | Pd-carbene catalyzed carbonylation reactions of aryl iodides. | 2011 | Dalton Trans | pmid:21677940 |
| Schumacher M et al. | Potential role of P-gp for flavone-induced diminished apoptosis and increased adenoma size in the small intestine of APC(min/+) mice. | 2011 | Cancer Invest. | pmid:21649465 |
| Fan Y et al. | Epimedium polysaccharide and propolis flavone can synergistically inhibit the cellular infectivity of NDV and improve the curative effect of ND in chicken. | 2011 | Int. J. Biol. Macromol. | pmid:21238483 |
| Boyle SP et al. | Evaluation of quality control strategies in Scutellaria herbal medicines. | 2011 | J Pharm Biomed Anal | pmid:21163602 |
| Bensasson RV et al. | Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. | 2011 | Free Radic. Biol. Med. | pmid:21745563 |
| Cai WJ et al. | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. | 2011 | PLoS ONE | pmid:22216122 |
| Derdemezis CS et al. | Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. | 2011 | Biochem Res Int | pmid:21949907 |