FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.
To understand associated biological information of FLAVONE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
FLAVONE is suspected in Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Chronic Disease, Disintegration, Cardiovascular Diseases, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with FLAVONE
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tamura M et al. | Effects of flavonoid compounds on the activity of NADPH diaphorase prepared from the mouse brain. | 1994 | Jpn. J. Pharmacol. | pmid:7990275 |
Monici M et al. | Flavone photoreactivity. UV-induced reactions in organic solvents and micellar systems. | 1993 | J. Photochem. Photobiol. B, Biol. | pmid:8271117 |
Valenti P et al. | Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells. | 1993 | Anticancer Drug Des. | pmid:8251042 |
Barrellier MT | [Lymphedema: is there a treatment?]. | 1992 Jan-Feb | Rev Med Interne | pmid:1410875 |
Liu H and Wehmeyer KR | Solid-phase extraction with supercritical fluid elution as a sample preparation technique for the ultratrace analysis of flavone in blood plasma. | 1992 | J. Chromatogr. | pmid:1400746 |
Le Bon AM et al. | Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. | 1992 | Chem. Biol. Interact. | pmid:1643669 |
Siess MH et al. | Dietary modification of drug-metabolizing enzyme activities: dose-response effect of flavonoids. | 1992 | J Toxicol Environ Health | pmid:1602520 |
Minagawa N et al. | Possible involvement of superoxide anion in the induction of cyanide-resistant respiration in Hansenula anomala. | 1992 | FEBS Lett. | pmid:1318225 |
Morita K et al. | Stimulatory actions of bioflavonoids on tyrosine uptake into cultured bovine adrenal chromaffin cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:1977385 |
Ibrahim AR and Abul-Hajj YJ | Microbiological transformation of flavone and isoflavone. | 1990 | Xenobiotica | pmid:2346033 |
Desoize B et al. | Response of primary tumour, spontaneous metastases and recurrence of Lewis lung carcinoma (3LL) to flavone acetic acid (FAA, LM975). | 1989 Nov-Dec | Anticancer Res. | pmid:2627123 |
Lee DW and Park KH | Testosterone metabolism by microsomal cytochrome P-450 in liver of rats treated with some inducers. | 1989 | Int. J. Biochem. | pmid:2502444 |
Tranchand B et al. | [Phase I pharmacokinetics of flavone-acetic acid]. | 1989 | Bull Cancer | pmid:2620114 |
Hill S et al. | Vascular collapse after flavone acetic acid: a possible mechanism of its anti-tumour action. | 1989 | Eur J Cancer Clin Oncol | pmid:2591434 |
Ching LM and Baguley BC | Hyporesponsiveness of macrophages from C3H/HeJ (endotoxin-resistant) mice to the antitumour agent flavone acetic acid (NSC 347512). | 1989 | Eur J Cancer Clin Oncol | pmid:2591444 |
Chabot GG et al. | Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. | 1989 | Cancer Chemother. Pharmacol. | pmid:2597279 |
Ching LM and Baguley BC | Reduction of cytotoxic effector cell activity in colon 38 tumours following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2597283 |
Baguley BC et al. | Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on colon 38 tumours in mice. | 1989 | Eur J Cancer Clin Oncol | pmid:2702981 |
Lewis CR et al. | Autonomic neuropathy following treatment with flavone acetic acid. | 1989 | Eur J Cancer Clin Oncol | pmid:2703010 |
Lonchampt M et al. | Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. | 1989 | Arzneimittelforschung | pmid:2818676 |